| 2025 Mexico City Open | |
|---|---|
| Date | 7 – 13 April |
| Edition | 4th |
| Surface | Clay |
| Location | Mexico City, Mexico |
| Champions | |
| Singles | |
 Felipe Meligeni Alves | |
| Doubles | |
 Santiago González /  Austin Krajicek | |
The 2025 Mexico City Open was a professional tennis tournament played on clay courts. It was the fourth edition of the tournament which was part of the 2025 ATP Challenger Tour. It took place in Mexico City, Mexico between 7 and 13 April 2025. [1]
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 AUS | James Duckworth | 89 | 1 |
 ARG | Thiago Agustín Tirante | 111 | 2 |
 FRA | Adrian Mannarino | 144 | 3 |
| BRA | Felipe Meligeni Alves | 152 | 4 |
| ARG | Juan Pablo Ficovich | 155 | 5 |
 CAN | Alexis Galarneau | 162 | 6 |
 SUI | Marc-Andrea Hüsler | 168 | 7 |
| FRA |
The following players received wildcards into the singles main draw:
Rodrigo Alujas Darwin Blanch Alex Hernández The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Juan Carlos Aguilar Andres Martin 
Maximilian Neuchrist Neil Oberleitner Alfredo Perez Pedro Sakamoto The following player received entry as a lucky loser:
Felipe Meligeni Alves def. Luka Pavlovic 6–3, 6–3. Santiago González / Austin Krajicek def. Ryan Seggerman / Patrik Trhac 7–6(11–9), 3–6, [10–5].