| 2025 Macedonian Open | |
|---|---|
| Date | 19–24 May |
| Edition | 3rd |
| Surface | Clay |
| Location | Skopje, North Macedonia |
| Champions | |
| Singles | |
 Jay Clarke | |
| Doubles | |
 Andrew Paulson / Michael Vrbenský | |
The 2025 Macedonian Open was a professional tennis tournament played on clay courts. It was the third edition of the tournament which was part of the 2025 ATP Challenger Tour. It took place in Skopje, North Macedonia between 19 and 24 May 2025.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 BOL | Hugo Dellien | 103 | 1 |
 HUN | |||
| GBR | Jay Clarke | 233 | 3 |
 ESP | Oriol Roca Batalla | 240 | 4 |
 NOR | Viktor Durasovic | 246 | 5 |
| Marat Sharipov | 247 | 6 | |
 NED | Max Houkes | 249 | 7 |
 CRO | Mili Poljičak | 270 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw through the Junior Accelerator programme:
The following player received entry into the singles main draw through the Next Gen Accelerator programme:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Franco Agamenone 
Manas Dhamne 
Nerman Fatić 
Toby Kodat 
Lilian Marmousez
Neil Oberleitner The following players received entry as lucky losers:
Jay Clarke def. Nerman Fatić 6–2, 6–3. Andrew Paulson / Michael Vrbenský def. Sriram Balaji / 
Miguel Ángel Reyes-Varela 2–6, 6–4, [10–6].
