| 2025 Open Sopra Steria de Lyon | |
|---|---|
| Date | 9–15 June |
| Edition | 9th |
| Surface | Clay |
| Location | Lyon, France |
| Champions | |
| Singles | |
 Marco Trungelliti | |
| Doubles | |
 Hsu Yu-hsiou /  Kaichi Uchida | |
The 2025 Open Sopra Steria de Lyon was a professional tennis tournament played on clay courts. It was the 9th edition of the tournament which was part of the 2025 ATP Challenger Tour. It took place in Lyon, France, between 9 and 15 June 2025.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 ESP | Pablo Carreño Busta | 99 | 1 |
 DEN | Elmer Møller | 112 | 2 |
 FRA | Arthur Cazaux | 113 | 3 |
| FRA | Kyrian Jacquet | 150 | 4 |
| ARG | Juan Pablo Ficovich | 152 | 5 |
 IND | Sumit Nagal | 170 | 6 |
| FRA | Calvin Hemery | 171 | 7 |
| ARG | Marco Trungelliti | 177 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Nicolás Álvarez Varona 
Matthew Dellavedova Maxime Janvier Timo Legout Lucas Poullain
Michael Vrbenský Marco Trungelliti def. Daniel Mérida 6–3, 4–6, 6–3. Hsu Yu-hsiou / Kaichi Uchida def. Luca Sanchez / Seita Watanabe 1–6, 6–3, [12–10].