| 2025 Little Rock Challenger | |
|---|---|
| Date | May 26 – June 1 |
| Edition | 6th |
| Surface | Hard |
| Location | Little Rock, Arkansas, United States |
| Champions | |
| Singles | |
 Patrick Kypson | |
| Doubles | |
 Aziz Dougaz /  Antoine Escoffier | |
The 2025 UAMS Health Little Rock Open was a professional tennis tournament played on hardcourts. It was the sixth edition of the tournament which was part of the 2025 ATP Challenger Tour. It took place in Little Rock, Arkansas, United States from May 26 to June 1, 2025. [1]
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| USA | Mitchell Krueger | 141 | 1 |
 CAN | Liam Draxl | 148 | 2 |
 JPN | Yuta Shimizu | 192 | 3 |
| CAN | Alexis Galarneau | 203 | 4 |
 ARG | Santiago Rodríguez Taverna | 209 | 5 |
| FRA | Antoine Escoffier | 218 | 6 |
| TUN | Aziz Dougaz | 222 | 7 |
 GBR | Paul Jubb | 238 | 8 |
The following players received wildcards into the singles main draw:
Alexander Kotzen Michael Zheng The following player received entry into the singles main draw using a protected ranking:
The following player received entry into the singles main draw through the Junior Accelerator programme:
The following players received entry from the qualifying draw:
Nicolás Kicker Stefan Kozlov Patrick Kypson Daniel Milavsky Kenta Miyoshi
Adrià Soriano Barrera The following player received entry as a lucky loser:
Patrick Kypson def. Michael Zheng 6–1, 1–6, 7–5. Aziz Dougaz / Antoine Escoffier def. 
Andrés Andrade / Nicolás Mejía 6–2, 6–3.
