| 2025 Challenger de Buenos Aires | |
|---|---|
| Date | 22 – 28 September |
| Edition | 14th |
| Surface | Clay |
| Location | Buenos Aires, Argentina |
| Champions | |
| Singles | |
 Román Andrés Burruchaga | |
| Doubles | |
| Guillermo Durán / Mariano Kestelboim | |
The 2025 YPF Buenos Aires Challenger was a professional tennis tournament played on clay courts. It was the 14th edition of the tournament which was part of the 2025 ATP Challenger Tour. It took place in Buenos Aires, Argentina between 22 and 28 September 2025.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| ARG | Thiago Agustín Tirante | 94 | 1 |
 USA | Emilio Nava | 100 | 2 |
 BOL | Hugo Dellien | 124 | 3 |
 CHI | Cristian Garín | 126 | 4 |
| ARG | Juan Pablo Ficovich | 132 | 5 |
| ARG | Román Andrés Burruchaga | 146 | 6 |
 ITA | Francesco Maestrelli | 159 | 7 |
 LBN | Hady Habib | 172 | 8 |
The following players received wildcards into the singles main draw:
Facundo Bagnis Guido Iván Justo Juan Bautista Torres The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Luciano Emanuel Ambrogi Hernán Casanova 
Daniel Dutra da Silva Lorenzo Joaquín Rodríguez
Juan Pablo Varillas Gonzalo Villanueva Román Andrés Burruchaga def. Alex Barrena 7–6(7–4), 6–3. Guillermo Durán / Mariano Kestelboim def. Pedro Boscardin Dias / João Lucas Reis da Silva 7–6(7–3), 6–1.