| 2025 San Marino Open | |
|---|---|
| Date | 14 – 20 July |
| Edition | 32nd |
| Location | City of San Marino, San Marino |
| Champions | |
| Singles | |
 Lukáš Klein | |
| Doubles | |
 Karol Drzewiecki /  Ray Ho | |
The 2025 San Marino Open was a professional tennis tournament played on clay courts. The 32nd edition of the tournament, which was part of the 2025 ATP Challenger Tour, took place in City of San Marino, San Marino between 14 and 20 July 2025.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 FRA | Valentin Royer | 113 | 1 |
 ARG | Thiago Agustín Tirante | 121 | 2 |
 ITA | Matteo Gigante | 133 | 3 |
| FRA | Kyrian Jacquet | 148 | 4 |
 CRO | Dino Prižmić | 159 | 5 |
| ARG | Federico Agustín Gómez | 161 | 6 |
 AUT | Lukas Neumayer | 169 | 7 |
| FRA | Ugo Blanchet | 173 | 8 |
The following players received wildcards into the singles main draw:
Pierluigi Basile Carlo Alberto Caniato Federico Cinà The following player received entry into the singles main draw through the Next Gen Accelerator programme:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Lukáš Klein def. Dino Prižmić 6–3, 6–4. Karol Drzewiecki / Ray Ho def. Miloš Karol / 
Vitaliy Sachko 7–5, 7–6(7–3).
