| 2025 Guangzhou Huangpu International Tennis Open | |
|---|---|
| Date | 8–14 September |
| Edition | 2nd |
| Surface | Hard |
| Location | Guangzhou, China |
| Champions | |
| Singles | |
 Juan Manuel Cerúndolo | |
| Doubles | |
 Matthew Romios /  Ryan Seggerman | |
The 2025 Guangzhou Huangpu International Tennis Open was a professional tennis tournament played on hardcourts. It was the second edition of the tournament which was part of the 2025 ATP Challenger Tour. It took place in Guangzhou, China between 8 and 14 September 2025.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| AUS | Christopher O'Connell | 81 | 1 |
| ARG | Juan Manuel Cerúndolo | 88 | 2 |
| USA | Nishesh Basavareddy | 104 | 3 |
 GEO | Nikoloz Basilashvili | 108 | 4 |
| USA | |||
 CHI | Alejandro Tabilo | 122 | 6 |
 GBR | Dan Evans | 136 | 7 |
| GBR | Billy Harris | 151 | 8 |
 JPN | Taro Daniel | 166 | 9 |
1 Rankings are as of 25 August 2025. [1]
The following players received wildcards into the singles main draw:
Charles Chen Te Rigele Xiao LinangThe following player received entry into the singles main draw as an alternate:
Petr Bar BiryukovThe following players received entry from the qualifying draw:
Alexandr Binda
Luca Castelnuovo Yuta Kikuchi
Ramkumar Ramanathan 
Kasidit Samrej Zhang TianhuiThe following player received entry as a lucky loser:
Juan Manuel Cerúndolo def. Alejandro Tabilo 6–2, 6–3. Matthew Romios / Ryan Seggerman def. Kaito Uesugi / Seita Watanabe 6–1, 6–3.