23S rRNA (guanine1835-N2)-methyltransferase

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23S rRNA (guanine1835-N2)-methyltransferase
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EC no. 2.1.1.174
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23S rRNA (guanine1835-N2)-methyltransferase (EC 2.1.1.174, ygjO (gene), rlmG (gene), ribosomal RNA large subunit methyltransferase G) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanine1835-N2)-methyltransferase. [1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine 1835 in 23S rRNA S-adenosyl-L-homocysteine + N2-methylguanine1835 in 23S rRNA

The enzyme methylates 23S rRNA in vitro, assembled 50S subunits are not a substrate.

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References

  1. ↑ Sergiev PV, Lesnyak DV, Bogdanov AA, Dontsova OA (November 2006). "Identification of Escherichia coli m2G methyltransferases: II. The ygjO gene encodes a methyltransferase specific for G1835 of the 23 S rRNA". Journal of Molecular Biology. 364 (1): 26–31. doi:10.1016/j.jmb.2006.09.008. PMID   17010380.
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