7-cyano-7-deazaguanine synthase

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7-Cyano-7-deazaguanine synthase
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EC no. 6.3.4.20
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7-cyano-7-deazaguanine synthase (EC 6.3.4.20, preQ0 synthase, 7-cyano-7-carbaguanine synthase, queC (gene)) is an enzyme with systematic name 7-carboxy-7-carbaguanine:ammonia ligase (ADP-forming). [1] [2] This enzyme catalyses the following chemical reaction

7-carboxy-7-carbaguanine + NH3 + ATP 7-cyano-7-carbaguanine + ADP + phosphate + H2O

This enzyme binds Zn2+.

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7-Carboxy-7-deazaguanine synthase (EC 4.3.99.3, 7-carboxy-7-carbaguanine synthase, queE (gene)) is an enzyme with systematic name 6-carboxy-5,6,7,8-tetrahydropterin ammonia-lyase. This enzyme catalyses the following chemical reaction

References

  1. McCarty RM, Somogyi A, Lin G, Jacobsen NE, Bandarian V (May 2009). "The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ(0) from guanosine 5'-triphosphate in four steps". Biochemistry. 48 (18): 3847–52. doi:10.1021/bi900400e. PMC   2693876 . PMID   19354300.
  2. Cicmil N, Huang RH (August 2008). "Crystal structure of QueC from Bacillus subtilis: an enzyme involved in preQ1 biosynthesis". Proteins. 72 (3): 1084–8. doi:10.1002/prot.22098. PMID   18491386.