Adenosylcobinamide-phosphate synthase

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Adenosylcobinamide-phosphate synthase
Identifiers
EC no. 6.3.1.10
CAS no. 905988-16-1
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Adenosylcobinamide-phosphate synthase (EC 6.3.1.10, CbiB) is an enzyme with systematic name adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming). [1] [2] This enzyme catalyses the following chemical reaction

Contents

(1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate ADP + phosphate + adenosylcobinamide phosphate
(2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol ADP + phosphate + adenosylcobinamide

One of the substrates, (R)-1-aminopropan-2-yl phosphate, is produced by CobD (EC 4.1.1.81). This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B12) in bacteria.

See also

Related Research Articles

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References

  1. Cheong CG, Bauer CB, Brushaber KR, Escalante-Semerena JC, Rayment I (April 2002). "Three-dimensional structure of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica". Biochemistry. 41 (15): 4798–808. CiteSeerX   10.1.1.564.9386 . doi:10.1021/bi012111w. PMID   11939774.
  2. Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (August 2002). "The biosynthesis of adenosylcobalamin (vitamin B12)". Natural Product Reports. 19 (4): 390–412. doi:10.1039/b108967f. PMID   12195810.