The Alpins Method is a system to plan and analyze the results of refractive surgical procedures, such as laser in-situ keratomileus (LASIK). [1] [2] [3] The Alpins Method is also used to plan cataract/toric intraocular lens (IOL) surgical procedures. [4]
The Alpins Method uses vector mathematics to determine a goal for astigmatism correction and analyze factors involved if treatment fails to reach that goal. The method can also be used to refine surgical techniques or correct laser settings in future procedures. [5]
In the early 1990s, astigmatism analysis and treatment applied to laser modalities was inconsistent and did not assess the success of the results or the extent to which surgical goals had been achieved. [6] The advent of excimer laser technology (e.g., laser-assisted in situ keratomileusis, or LASIK) also introduced a conundrum between incisional and ablation techniques; specifically, should treatment be planned according to refractive cylinder values as introduced with laser refractive surgery, or corneal astigmatism parameters as had been customary with incisional surgery. [7] [8]
Developed by Australian ophthalmologist Noel Alpins and introduced in 1993, the Alpins Method provides a coherent basis for reporting astigmatism results, and on this basis became the standard in the major ophthalmology journals, [9] [10] [11] and was accepted worldwide for studies that include refraction and corneal astigmatism measurements. [2] [12] [13] The method provides a consistent, logical approach to quantifying and comparing the success of various refractive surgical procedures, and refining/planning surgery to achieve even better results, both in individuals and groups of individuals receiving refractive surgery.
The Alpins Method has been used in some research studies of LASIK. [1] [2] [3] [14] In 2006 the American National Standards Institute (ANSI) published guidelines based on the Alpins Method, designed to help manufacturers demonstrate the efficacy of refractive surgical lasers. [3] [12] [13]
The Alpins Method determines a treatment path and defined an astigmatic target that in many instances is not zero, although prior to the Alpins Method zero had been a nearly unanimous, but unachievable, preference.
The Alpins Method of astigmatism analysis has many parallels to the game of golf. [5] A golf putt is a vector, possessing magnitude (length) and axis (direction). The intended putt (the path from the ball to the hole) corresponds to Alpins' target-induced astigmatism vector (TIA), which is the astigmatic change (by magnitude and axis) the surgeon intends to induce to correct the patient's pre-existing astigmatism to the derived or calculated target. The actual putt (the path the ball follows when hit) corresponds to Alpins' surgical-induced astigmatism vector (SIA), which is the amount and axis of astigmatic change the surgeon induces. If the golfer misses the cup, the difference vector (DV) corresponds to the second putt—that is, a putt (by magnitude and axis) that would allow the golfer to hit the cup (the surgeon to completely correct it) on a second attempt. [15]
The diagram superimposed on the golf putt image corresponds to a double-angle vector diagram (DAVD), which allows calculations using rectangular (Cartesian) coordinates. Vectors can only be calculated; they cannot be measured like astigmatism. Line 1 in the diagram represents a patient's preoperative astigmatism by magnitude (length of the line) and axis (which in a DAVD is twice the patient's measured axis of preoperative astigmatism). Line 2 represents the target astigmatism—that is, the magnitude and axis of the correction the surgeon would like to achieve. Line 3 represents the achieved astigmatism—that is, the magnitude and axis of postoperative astigmatism.
The TIA, SIA, and DV and their various relationships generate the following indices, which comprise the essence of the Alpins Method: [15] [16]
Clinical studies support vector planning both in healthy astigmatic eyes [17] [18] [19] and in eyes with keratoconus. [20]
Additionally, Alpins and Stamatelatos showed that combining refraction (using wavefront measurements) with Vector Planning provided better visual outcomes than using wavefront planning alone. [17] [21]
In astigmatism treatments using Vector Planning, with the advance of tomography devices, various corneal astigmatism parameters can now be measured for different parts of the cornea (predominantly, one corneal parameter and one refractive parameter is used). [22] By dividing the cornea into 2 halves, a total corneal astigmatism parameter can be measured for each half of the cornea with varying emphases on corneal and refractive parameters, maximally reducing the astigmatism for each half.
LASIK or Lasik, commonly referred to as laser eye surgery or laser vision correction, is a type of refractive surgery for the correction of myopia, hyperopia, and an actual cure for astigmatism, since it is in the cornea. LASIK surgery is performed by an ophthalmologist who uses a laser or microkeratome to reshape the eye's cornea in order to improve visual acuity.
An optical system with astigmatism is one where rays that propagate in two perpendicular planes have different foci. If an optical system with astigmatism is used to form an image of a cross, the vertical and horizontal lines will be in sharp focus at two different distances. The term comes from the Greek α- (a-) meaning "without" and στίγμα (stigma), "a mark, spot, puncture".
Eye surgery, also known as ophthalmic surgery or ocular surgery, is surgery performed on the eye or its adnexa. Eye surgery is part of ophthalmology and is performed by an ophthalmologist or eye surgeon. The eye is a fragile organ, and requires due care before, during, and after a surgical procedure to minimize or prevent further damage. An eye surgeon is responsible for selecting the appropriate surgical procedure for the patient, and for taking the necessary safety precautions. Mentions of eye surgery can be found in several ancient texts dating back as early as 1800 BC, with cataract treatment starting in the fifth century BC. It continues to be a widely practiced class of surgery, with various techniques having been developed for treating eye problems.
Radial keratotomy (RK) is a refractive surgical procedure to correct myopia (nearsightedness). It was developed in 1974 by Svyatoslav Fyodorov, a Russian ophthalmologist. It has been largely supplanted by newer, more accurate operations, such as photorefractive keratectomy, LASIK, Epi-LASIK and the phakic intraocular lens.
Refractive surgery is an optional eye surgery used to improve the refractive state of the eye and decrease or eliminate dependency on glasses or contact lenses. This can include various methods of surgical remodeling of the cornea (keratomileusis), lens implantation or lens replacement. The most common methods today use excimer lasers to reshape the curvature of the cornea. Refractive eye surgeries are used to treat common vision disorders such as myopia, hyperopia, presbyopia and astigmatism.
Phacoemulsification is a cataract surgery method in which the internal lens of the eye which has developed a cataract is emulsified with the tip of an ultrasonic handpiece and aspirated from the eye. Aspirated fluids are replaced with irrigation of balanced salt solution to maintain the volume of the anterior chamber during the procedure. This procedure minimises the incision size and reduces the recovery time and risk of surgery induced astigmatism.
An Intraocular lens (IOL) is a lens implanted in the eye usually as part of a treatment for cataracts or for correcting other vision problems such as short sightedness and long sightedness; a form of refractive surgery. If the natural lens is left in the eye, the IOL is known as phakic, otherwise it is a pseudophakic lens. Both kinds of IOLs are designed to provide the same light-focusing function as the natural crystalline lens. This can be an alternative to LASIK, but LASIK is not an alternative to an IOL for treatment of cataracts.
A phakic intraocular lens (PIOL) is an intraocular lens that is implanted surgically into the eye to correct refractive errors without removing the natural lens. Intraocular lenses that are implanted into eyes after the eye's natural lens has been removed during cataract surgery are known as pseudophakic.
Corneal topography, also known as photokeratoscopy or videokeratography, is a non-invasive medical imaging technique for mapping the anterior curvature of the cornea, the outer structure of the eye. Since the cornea is normally responsible for some 70% of the eye's refractive power, its topography is of critical importance in determining the quality of vision and corneal health.
Astigmatism is a type of refractive error due to rotational asymmetry in the eye's refractive power. This results in distorted or blurred vision at any distance. Other symptoms can include eyestrain, headaches, and trouble driving at night. Astigmatism often occurs at birth and can change or develop later in life. If it occurs in early life and is left untreated, it may result in amblyopia.
ReLExSmall incision lenticule extraction (SMILE), second generation of ReLEx Femtosecond lenticule extraction (FLEx), is a form of laser based refractive eye surgery developed by Carl Zeiss Meditec used to correct myopia, and cure astigmatism. Although similar to LASIK laser surgery, the intrastromal procedure uses a single femtosecond laser referenced to the corneal surface to cleave a thin lenticule from the corneal stroma for manual extraction.
Pellucid marginal degeneration (PMD) is a degenerative corneal condition, often confused with keratoconus. It typically presents with painless vision loss affecting both eyes. Rarely, it may cause acute vision loss with severe pain due to perforation of the cornea. It is typically characterized by a clear, bilateral thinning (ectasia) in the inferior and peripheral region of the cornea, although some cases affect only one eye. The cause of the disease remains unclear.
Diffuse lamellar keratitis (DLK) is a sterile inflammation of the cornea which may occur after refractive surgery, such as LASIK. Its incidence has been estimated to be 1 in 500 patients, though this may be as high as 32% in some cases.
Jeff Machat MD, FRCSC, DABO is an ophthalmologist in the United States and Canada specializing in surgical vision correction better known as refractive eye surgery.
Peter S. Hersh is an American ophthalmologist, researcher, and specialist in LASIK eye surgery, keratoconus, and diseases of the cornea. He co-authored the article in the journal Ophthalmology that presented the results of the study that led to the first approval by the U.S. Food and Drug Administration (FDA) of the excimer laser for the correction of nearsightedness in the United States. Hersh was also medical monitor of the study that led to approval of corneal collagen crosslinking for the treatment of keratoconus. He was the originator, in 2015, of CTAK for keratoconus, patent holder, and co-developer.
The eye, like any other optical system, suffers from a number of specific optical aberrations. The optical quality of the eye is limited by optical aberrations, diffraction and scatter. Correction of spherocylindrical refractive errors has been possible for nearly two centuries following Airy's development of methods to measure and correct ocular astigmatism. It has only recently become possible to measure the aberrations of the eye and with the advent of refractive surgery it might be possible to correct certain types of irregular astigmatism.
Sheraz Daya is a British ophthalmologist. Daya founded the Centre for Sight in 1996, and works in stem-cell research and sight restoration and correction surgery.
Noel Alpins is an Australian ophthalmologist who developed the Alpins method of astigmatism analysis used in refractive, corneal, and cataract surgery, used in the research of LASIK.
Allon Barsam is a London-based ophthalmologist specializing in cataract surgery, refractive surgery and corneal and external eye disease. Barsam carried out the first human treatments of microwave keratoplasty.
Anastasios John Kanellopoulos is a Greek-American eye surgeon specializing in corneal transplantation, cornea crosslinking for keratoconus, complicated cataract surgery and complicated glaucoma. Widely known for research and clinical contributions in micro-incision cataract, customized laser refractive surgery and corneal cross-linking propagation and most innovations, reducing corneal transplants for advanced keratoconus.