apigenin 4'-O-methyltransferase | |||||||||
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Identifiers | |||||||||
EC no. | 2.1.1.75 | ||||||||
CAS no. | 118251-36-8 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an apigenin 4'-O-methyltransferase (EC 2.1.1.75) is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are S-adenosyl methionine and 5,7,4'-trihydroxyflavone (apigenin), whereas its two products are S-adenosylhomocysteine and 4'-methoxy-5,7-dihydroxyflavone (acacetin).
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:5,7,4'-trihydroxyflavone 4'-O-methyltransferase. Other names in common use include flavonoid O-methyltransferase, and flavonoid methyltransferase. This enzyme participates in flavonoid biosynthesis.
Apigenin (4′,5,7-trihydroxyflavone), found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally occurring glycosides. It is a yellow crystalline solid that has been used to dye wool.
Flavones are a class of flavonoids based on the backbone of 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one).
In enzymology, a 3-demethylubiquinone-9 3-O-methyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a 3-methylquercetin 7-O-methyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a caffeate O-methyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, an isoflavone 4'-O-methyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, an isoflavone 7-O-methyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a kaempferol 4'-O-methyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a luteolin O-methyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a quercetin 3-O-methyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a flavone apiosyltransferase is an enzyme that catalyzes the chemical reaction
Isorhamnetin is an O-methylated flavon-ol from the class of flavonoids. A common food source of this 3'-methoxylated derivative of quercetin and its glucoside conjugates are pungent yellow or red onions, in which it is a minor pigment, quercetin-3,4'-diglucoside and quercetin-4'-glucoside and the aglycone quercetin being the major pigments. Pears, olive oil, wine and tomato sauce are rich in isorhamnetin. Others sources include the spice, herbal medicinal and psychoactive Mexican tarragon (Tagetes lucida), which is described as accumulating isorhamnetin and its 7-O-glucoside derivate. Nopal is also a good source of isorhamnetin, which can be extracted by supercritical fluid extraction assisted by enzymes.
The O-methylated flavonoids or methoxyflavonoids are flavonoids with methylations on hydroxyl groups. O-methylation has an effect on the solubility of flavonoids.
Acacetin is a 4′-O-methylated flavone of the parent compound apigenin, found in Robinia pseudoacacia, Turnera diffusa (damiana), shows moderate aromatase inhibition, Betula pendula, and in the fern Asplenium normale.
TRNA (carboxymethyluridine34-5-O)-methyltransferase is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (carboxymethyluridine34-5-O)-methyltransferase. This enzyme catalyses the following chemical reaction
Flavonoid 4'-O-methyltransferase is an enzyme with systematic name S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase. This enzyme catalyses the following chemical reaction
Naringenin 7-O-methyltransferase is a methyltransferase isolated from rice, which catalyzes the biosynthesis of sakuranetin.
Trans-resveratrol di-O-methyltransferase is an enzyme with systematic name S-adenosyl-L-methionine:trans-resveratrol 3,5-O-dimethyltransferase. This enzyme catalyses the following chemical reaction
2,4,7-trihydroxy-1,4-benzoxazin-3-one-glucoside 7-O-methyltransferase is an enzyme with systematic name S-adenosyl-L-methionine:(2R)-4,7-dihydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl β-D-glucopyranoside 7-O-methyltransferase. This enzyme catalyses the following chemical reaction