Baruol synthase

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Baruol synthase
Identifiers
EC no. 5.4.99.57
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
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PMC articles
PubMed articles
NCBI proteins

Baruol synthase (EC 5.4.99.57, BARS1) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, baruol-forming). [1] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene baruol

The enzyme from Arabidopsis thaliana also produces traces of 22 other triterpenoids.

References

  1. Lodeiro S, Xiong Q, Wilson WK, Kolesnikova MD, Onak CS, Matsuda SP (September 2007). "An oxidosqualene cyclase makes numerous products by diverse mechanisms: a challenge to prevailing concepts of triterpene biosynthesis". Journal of the American Chemical Society. 129 (36): 11213–22. Bibcode:2007JAChS.12911213L. doi:10.1021/ja073133u. PMID   17705488.