State Route 58 is a major east-west state highway in the U.S. state of California that runs across the Coast Ranges, the southern San Joaquin Valley, the Tehachapi Mountains, which border the southern Sierra Nevada, and the Mojave Desert. It runs between U.S. Route 101 near Santa Margarita and Interstate 15 in Barstow. It has junctions with Interstate 5 near Buttonwillow, State Route 99 in Bakersfield, State Route 202 in Tehachapi, State Route 14 near Mojave, and U.S. Route 395 at Kramer Junction. SR 58 also provides access to Edwards Air Force Base. At various points it is known as the Calf Canyon Highway, Carrisa Highway, Bakersfield-McKittrick Highway, Rosa Parks Highway, Rosedale Highway, Barstow-Bakersfield Highway, Bakersfield Tehachapi Highway, Kern County Korean War Veterans Memorial Highway, and Mojave-Barstow Highway.
State Route 86 is a north–south state highway in the U.S. State of California that connects the Imperial and Coachella valleys in the southeastern desert region of the state. It runs from State Route 111 near the Mexican border crossing at Calexico north through the Imperial Valley via El Centro and Brawley, and around the west side of the Salton Sea into the Coachella Valley. It then goes through Coachella before terminating at Interstate 10 in Indio.
State Route 37 is a state highway in the U.S. state of California that runs 21 miles (34 km) along the northern shore of San Pablo Bay. It serves as a vital connection in the North Bay region of the San Francisco Bay Area, running from U.S. Route 101 in Novato, through northeastern Marin County, and the southern tips of both Sonoma and Solano Counties to Interstate 80 in Vallejo. Sonoma Raceway and Six Flags Discovery Kingdom are accessible from Highway 37.
State Route 120 is a state highway in the central part of California, connecting the San Joaquin Valley with the Sierra Nevada, Yosemite National Park, and the Mono Lake area. Its western terminus is at Interstate 5 in Lathrop, and its eastern terminus at U.S. Route 6 in Benton. While the route is signed as a contiguous route through Yosemite, the portion inside the park is federally maintained and is not included in the state route logs. The portion at Tioga Pass at Yosemite's eastern boundary is the highest paved through road in the California State Route system. This part is not maintained in the winter and is usually closed during the winter season.
State Route 23 is a state highway in the U.S. state of California that connects the Pacific coast and the Santa Monica Mountains to the Conejo and Santa Clara River valleys. It runs from Pacific Coast Highway in Malibu in Los Angeles County to Ventura Street in Fillmore in Ventura County.
State Route 84 is a state highway in the U.S. state of California that consists of two unconnected segments, one in the San Francisco Bay Area and the other primarily in the Sacramento–San Joaquin River Delta area.
State Route 116 (SR 116) is a state highway in the U.S. state of California in Sonoma County. The route runs from SR 1 on the Pacific coast near Jenner to SR 121 south of Sonoma.
State Route 299 is an east–west state highway in the U.S. state of California that runs across the northern part of the state. At 305.777 miles (492.100 km), it is the third longest California state route, after Route 1 and Route 99, and the longest east-west route. Route 299's western terminus is at US 101 at the northern edge of Arcata, and its eastern terminus is at the Nevada state line at a point east of Cedarville. Between Arcata and Redding, Route 299 intersects with State Route 96, and is briefly co-signed with State Route 3. In Redding, it intersects with State Route 273, State Route 44, and Interstate 5. East of Redding, it intersects with State Route 89, and a section is co-signed with State Route 139 before reaching Alturas. It is then co-signed with U.S. Route 395 northeast of Alturas, and then runs east through Cedarville and to the border with Nevada. A ghost town, Vya, Nevada, can be reached via this route, which after the border becomes a dirt road, which was formerly Nevada State Route 8A. The segment of SR 299 between Arcata and Redding is the Trinity Scenic Byway, a National Forest Scenic Byway.
State Route 12 is a state highway in the U.S. state of California that travels in an east–west direction from State Route 116 in Sebastopol in Sonoma County to State Route 49 just north of San Andreas in Calaveras County. The route connects the Sonoma and Napa valleys with the Sacramento–San Joaquin River Delta and the Sierra Foothills. It is constructed to freeway standards from the Fulton Road/South Wright Road stoplight in Santa Rosa, to its partial interchange with Farmers Lane.
State Route 33 is a north–south state highway in the U.S. state of California. It runs north from U.S. Route 101 in Ventura through the Transverse Ranges and the western side of the San Joaquin Valley to Interstate 5 at a point east of Tracy. SR 33 replaced part of U.S. Route 399 in 1964 during the "great renumbering" of routes. In the unincorporated sections of Kern County it is known as the West Side Highway. In addition, the California Legislature designated the entire Kern County portion as the Petroleum Highway in 2004. The southernmost portion in Ventura is a freeway known as the Ojai Freeway, while it is known as the Maricopa Highway from Ojai to Maricopa.
State Route 20 is a state highway in the northern-central region of the U.S. state of California, running east–west north of Sacramento from the North Coast to the Sierra Nevada. Its west end is at SR 1 in Fort Bragg, from where it heads east past Clear Lake, Colusa, Yuba City, Marysville and Nevada City to I-80 near Emigrant Gap, where eastbound traffic can continue on other routes to Lake Tahoe or Nevada.
State Route 156 is a west to east state highway in the U.S. state of California, running from State Route 1 in Castroville to State Route 152 near Hollister. It serves as part of the primary route from the Monterey Peninsula to either the San Francisco Bay Area or the California Central Valley.
State Route 32 is an east–west state highway in the U.S. State of California which is routed from Interstate 5 in Orland, across the Sacramento Valley and through Chico, through the northern Sierra Nevada, and ending at SR 36 and SR 89 in eastern Tehama County.
State Route 132 is a state highway in the U.S. state of California that connects the Central Valley with the Sierra Nevada foothills and the California Gold Country. Its western segment also connects the city of Modesto with the San Francisco Bay Area via I-580, although this route is discouraged due to it being a two-lane road between Modesto and Interstate 5. East of Modesto, the road climbs the foothills and eventually ends at SR 49 at Coulterville.
State Route 166 is a state highway in the U.S. state of California. It connects the Central Coast to the southern San Joaquin Valley, running from State Route 1 in Guadalupe and through Santa Maria in Santa Barbara County to State Route 99 in Mettler in Kern County.
State Route 45 is a state highway in the U.S. State of California that travels in a north–south direction in the Sacramento Valley from Route 113 in Knights Landing to Route 32 in Hamilton City.
State Route 53, also known as the Clearlake Expressway for part of its length, is a state highway in the U.S. state of California that runs in a north–south direction in Lake County east of Clear Lake, It connects SR 29 and SR 20 via the city of Clearlake.
State Route 121 is a state highway in the U.S. state of California. It runs through the Wine Country region of Sonoma and Napa counties. Its southern terminus is at State Route 37 at Sears Point, and its northern terminus is at State Route 128 near Lake Berryessa. SR 121 passes through the Carneros region of the southern Sonoma Valley and Napa Valley.
State Route 128 is a state highway in the U.S. state of California, connecting the Mendocino coast to the Sacramento Valley, through the state's Wine Country. It runs from State Route 1 near Albion to Interstate 505 in Winters.
State Route 221 is a state highway in the U.S. state of California that runs in and just outside the City of Napa, providing access to Napa Valley College and Napa State Hospital. The highway's southern terminus is with State Route 12 and State Route 29 outside the southeast corner of the city, and its northern terminus is at State Route 121 inside the city. SR 221 forms part of the Napa-Vallejo Highway with SR 29.
I-80 in Vallejo 
SR 20 at Upper Lake 
