State Route 58 is a major east-west state highway in the U.S. state of California that runs across the Coast Ranges, the southern San Joaquin Valley, the Tehachapi Mountains, which border the southern Sierra Nevada, and the Mojave Desert. It runs between U.S. Route 101 near Santa Margarita and Interstate 15 in Barstow. It has junctions with Interstate 5 near Buttonwillow, State Route 99 in Bakersfield, State Route 202 in Tehachapi, State Route 14 near Mojave, and U.S. Route 395 at Kramer Junction. SR 58 also provides access to Edwards Air Force Base. At various points it is known as the Calf Canyon Highway, Carrisa Highway, Bakersfield-McKittrick Highway, Rosa Parks Highway, Westside Parkway, Barstow-Bakersfield Highway, Bakersfield Tehachapi Highway, Kern County Korean War Veterans Memorial Highway, and Mojave-Barstow Highway.
State Route 37 is a state highway in the U.S. state of California that runs 21 miles (34 km) along the northern shore of San Pablo Bay. It serves as a vital connection in the North Bay region of the San Francisco Bay Area, running from U.S. Route 101 in Novato, through northeastern Marin County, and the southern tips of both Sonoma and Solano Counties to Interstate 80 in Vallejo. Sonoma Raceway and Six Flags Discovery Kingdom are accessible from Highway 37.
State Route 120 is a state highway in the central part of California, connecting the San Joaquin Valley with the Sierra Nevada, Yosemite National Park, and the Mono Lake area. Its western terminus is at Interstate 5 in Lathrop, and its eastern terminus is at U.S. Route 6 in Benton. While the route is signed as a contiguous route through Yosemite, the portion inside the park is federally maintained and is not included in the state route logs. The portion at Tioga Pass at Yosemite's eastern boundary is the highest paved through road in the California State Route system. This part is not maintained in the winter and is usually closed during the winter season.
State Route 118 is a state highway in the U.S. state of California that runs west to east through Ventura and Los Angeles counties. It travels from State Route 126 at the eastern edge of Ventura immediately northwest of Saticoy, then through Saticoy, in Ventura County east to Interstate 210 near Lake View Terrace in Los Angeles. SR 118 crosses the Santa Susana Pass and the northern rim of the San Fernando Valley along its route.
State Route 84 is a state highway in the U.S. state of California that consists of two unconnected segments, one in the San Francisco Bay Area and the other primarily in the Sacramento–San Joaquin River Delta area.
State Route 116 (SR 116) is a state highway in the U.S. state of California in Sonoma County. The route runs from SR 1 on the Pacific coast near Jenner to SR 121 south of Sonoma.
State Route 299 is an east–west state highway in the U.S. state of California that runs across the northern part of the state. At 305.777 miles (492.100 km), it is the third longest California state route, after Route 1 and Route 99, and the longest east-west route. Route 299's western terminus is at US 101 at the northern edge of Arcata, and its eastern terminus is at the Nevada state line at a point east of Cedarville. Between Arcata and Redding, Route 299 intersects with State Route 96, and is briefly co-signed with State Route 3. In Redding, it intersects with State Route 273, State Route 44, and Interstate 5. East of Redding, it intersects with State Route 89, and a section is co-signed with State Route 139 before reaching Alturas. It is then co-signed with U.S. Route 395 northeast of Alturas, and then runs east through Cedarville and to the border with Nevada. A ghost town, Vya, Nevada, can be reached via this route, which after the border becomes a dirt road, which was formerly Nevada State Route 8A. The segment of SR 299 between Arcata and Redding is the Trinity Scenic Byway, a National Forest Scenic Byway.
State Route 12 is a state highway in the U.S. state of California that travels in an east–west direction from State Route 116 in Sebastopol in Sonoma County to State Route 49 just north of San Andreas in Calaveras County. The route connects the Sonoma and Napa valleys with the Sacramento–San Joaquin River Delta and the Sierra Foothills. It is constructed to freeway standards from the Fulton Road/South Wright Road stoplight in Santa Rosa, to its partial interchange with Farmers Lane.
State Route 33 is a north–south state highway in the U.S. state of California. It runs north from U.S. Route 101 in Ventura through the Transverse Ranges and the western side of the San Joaquin Valley to Interstate 5 at a point east of Tracy. SR 33 replaced part of U.S. Route 399 in 1964 during the "great renumbering" of routes. In the unincorporated sections of Kern County it is known as the West Side Highway. In addition, the California Legislature designated the entire Kern County portion as the Petroleum Highway in 2004. The southernmost portion in Ventura is a freeway known as the Ojai Freeway, while it is known as the Maricopa Highway from Ojai to Maricopa.
State Route 20 is a state highway in the northern-central region of the U.S. state of California, running east–west north of Sacramento from the North Coast to the Sierra Nevada. Its west end is at SR 1 in Fort Bragg, from where it heads east past Clear Lake, Colusa, Yuba City, Marysville and Nevada City to I-80 near Emigrant Gap, where eastbound traffic can continue on other routes to Lake Tahoe or Nevada.
State Route 156 is a west to east state highway in the U.S. state of California, running from State Route 1 in Castroville to State Route 152 near Hollister. It serves as part of the primary route from the Monterey Peninsula to either the San Francisco Bay Area or the California Central Valley.
State Route 36 is an east–west state highway in the U.S. state of California that is routed from U.S. Route 101 in Humboldt County to U.S. Route 395 just east of Susanville in Lassen County. The highway passes through Red Bluff, the county seat of Tehama County, on the northern edge of the Sacramento Valley. The portion of SR 36 travelling past Lassen Volcanic National Park and Lake Almanor is part of the Volcanic Legacy Scenic Byway, a National Scenic Byway. Also, Route 36 between Alton and Susanville is a designated Blue Star Memorial Highway.
State Route 166 is a state highway in the U.S. state of California. It connects the Central Coast to the southern San Joaquin Valley, running from State Route 1 in Guadalupe and through Santa Maria in Santa Barbara County to State Route 99 in Mettler in Kern County.
State Route 53, also known as the Clearlake Expressway for part of its length, is a state highway in the U.S. state of California that runs in a north–south direction in Lake County east of Clear Lake, It connects SR 29 and SR 20 via the city of Clearlake.
State Route 70 is a state highway in the U.S. state of California, connecting SR 99 north of Sacramento with U.S. Route 395 near Beckwourth Pass via the Feather River Canyon. Through the Feather River Canyon, from SR 149 to US 395, SR 70 is the Feather River Scenic Byway, a Forest Service Byway that parallels the ex-Western Pacific Railroad's Feather River Route.
State Route 121 is a state highway in the U.S. state of California. It runs through the Wine Country region of Sonoma and Napa counties. Its southern terminus is at State Route 37 at Sears Point, and its northern terminus is at State Route 128 near Lake Berryessa. SR 121 passes through the Carneros region of the southern Sonoma Valley and Napa Valley.
State Route 127 is a state highway in the U.S. state of California that connects Interstate 15 in Baker to Nevada State Route 373 at the Nevada state line, passing near the eastern boundary of Death Valley National Park. The entire length of the highway closely follows the central portion of the former Tonopah and Tidewater Railroad and loosely follows the Amargosa River.
State Route 128 is a state highway in the U.S. state of California, connecting the Mendocino coast to the Sacramento Valley, through the state's Wine Country. It runs from State Route 1 near Albion to Interstate 505 in Winters.
State Route 168 is an east-west state highway in the U.S. state of California that is separated into two distinct segments by the Sierra Nevada. The western segment runs from State Routes 41 and 180 in Fresno east to Huntington Lake along the western slope of the Sierra. The eastern segment connects Lake Sabrina in the Eastern Sierra to State Route 266 in the community of Oasis, just to the west of the Nevada border. The eastern segment of SR 168 also forms a concurrency with U.S. Route 395 between Bishop and Big Pine.
State Route 221 is a state highway in the U.S. state of California that runs in and just outside the City of Napa, providing access to Napa Valley College and Napa State Hospital. The highway's southern terminus is with State Route 12 and State Route 29 outside the southeast corner of the city, and its northern terminus is at State Route 121 inside the city. SR 221 forms part of the Napa-Vallejo Highway with SR 29.
I-80 in Vallejo 
SR 20 at Upper Lake 
