Chemical restraint

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A chemical restraint is a form of medical restraint in which a drug is used to restrict the freedom or movement of a patient or in some cases to sedate the patient. Chemical restraint is used in emergency, acute, and psychiatric settings to perform surgery or to reduce agitation, aggression or violent behaviours; [lower-alpha 1] it may also be used to control or punish unruly behaviours. [2] Chemical restraint is also referred to as a " Psychopharmacologic Agent", " Psychotropic Drug " or "Therapeutic Restraints" in certain legal writing. [3] [4]

In the UK, NICE recommends the use of chemical restraint for acute behaviour disturbances (ABD), but only after verbal calming and de-escalation techniques have been attempted. It is viewed as superior to physical restraint, with physical restraints only being recommended for the administration of a chemical restraint. [lower-alpha 2]

In the United States, no drugs are presently approved by the U.S. Food and Drug Administration (FDA) for use as chemical restraints. [5] Drugs that are often used as chemical restraints include antipsychotics, benzodiazepines, [6] and dissociative anesthetics such as ketamine. A systematic review in 2019 advised the use of intravenous haloperidol (a short half-life, first-generation antipsychotic) alone or in conjunction with lorazepam or midazolam (short half-life benzodiazepines), but said more research was needed. [lower-alpha 3]

The Human Rights Watch wrote a report on the use of chemical restraints amongst the elderly in the US. It concluded that antipsychotic drugs are sometimes used almost by default to control difficult-to-manage residents. [2] The FDA estimates 15,000 elderly individuals in nursing homes die each year due to the unnecessary use of anti-psychotics. [7] According to the Nursing Home Reform Act, individuals have the right to be free from physical or chemical restraints imposed for purposes of discipline or convenience and not required to treat the resident's medical symptoms. [8]

The use of chemical restraint has been criticized. It is sometimes misused by health care workers for the convenience of the staff rather than the benefit of the patient, with workers using them to prevent patients from resisting care, rather than improving the health of the patient; [9] it can cause more confusion in patients, slowing their recovery; [10] and it can be unclear whether drugs used for chemical restraint are necessary to treat an underlying mental health condition or whether they are being used to sedate the patient. Patients can view chemical restraint as a violation of integrity and find the experience traumatic. [lower-alpha 4]

Notes

  1. "Chemical restraint, also known as rapid tranquilisation, is the use of psychotropic medication to control severe agitation, or violent behaviours." [1]
  2. "Sedation (rapid tranquilisation) will be required to facilitate rapid intervention and institution of potentially lifesaving treatments if an individual displaying [acute behaviour disturbance] ABD fails to respond to de-escalation techniques. The rapid control and calming of an individual displaying the extreme physical exertion associated with ABD is essential to prevent further worsening of their metabolic status. Ideally sedation should be administered via the intravenous route; however, this route is unlikely to be immediately available." "Guidelines for the Management of Excited Delirium / Acute Behavioural Disturbance (ABD)" (PDF). Archived from the original (PDF) on 2020-11-01. Retrieved 2020-08-29.
  3. "While there is a sizeable, good quality body of RCT [randomized controlled trial] evidence regarding chemical restraint practices from around the world, the interventions, outcome measures, and findings are heterogenous and preclude more than simple description. On the current evidence base from RCTs, front-line clinicians could be advised to use haloperidol (alone or in combination with lorazepam or midazolam) delivered via IV, oral, or IM methods, to safely, speedily, and effectively control agitated, aggressive, and violent behaviours." [1]
  4. "Chemical restraint can furthermore be experienced as a violation of integrity and cause psychological discomfort"; [1] "Further, the individual experience of any form of restraint is well recognized as traumatizing and anti-therapeutic". [1] :15

Related Research Articles

<span class="mw-page-title-main">Benzodiazepine</span> Class of depressant drugs

Benzodiazepines, colloquially called "benzos", are a class of depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring. They are prescribed to treat conditions such as anxiety disorders, insomnia, and seizures. The first benzodiazepine, chlordiazepoxide (Librium), was discovered accidentally by Leo Sternbach in 1955 and was made available in 1960 by Hoffmann–La Roche, who soon followed with diazepam (Valium) in 1963. By 1977, benzodiazepines were the most prescribed medications globally; the introduction of selective serotonin reuptake inhibitors (SSRIs), among other factors, decreased rates of prescription, but they remain frequently used worldwide.

<span class="mw-page-title-main">Haloperidol</span> Typical antipsychotic medication

Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. Haloperidol is used in the treatment of schizophrenia, tics in Tourette syndrome, mania in bipolar disorder, delirium, agitation, acute psychosis, and hallucinations from alcohol withdrawal. It may be used by mouth or injection into a muscle or a vein. Haloperidol typically works within 30 to 60 minutes. A long-acting formulation may be used as an injection every four weeks by people with schizophrenia or related illnesses, who either forget or refuse to take the medication by mouth.

Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure. Examples of drugs which can be used for sedation include isoflurane, diethyl ether, propofol, etomidate, ketamine, pentobarbital, lorazepam and midazolam.

<span class="mw-page-title-main">Akathisia</span> Movement disorder involving a feeling of inner restlessness

Akathisia is a movement disorder characterized by a subjective feeling of inner restlessness accompanied by mental distress and an inability to sit still. Usually, the legs are most prominently affected. Those affected may fidget, rock back and forth, or pace, while some may just have an uneasy feeling in their body. The most severe cases may result in aggression, violence, and/or suicidal thoughts. Akathisia is also associated with threatening behaviour and physical aggression that is greatest in patients with mild akathisia, and diminishing with increasing severity of akathisia.

<span class="mw-page-title-main">Temazepam</span> Insomnia medication

Temazepam is a medication of the benzodiazepine class which is generally used to treat severe or debilitating insomnia. It is taken by mouth. Temazepam is rapidly absorbed, and significant hypnotic effects begin in less than 30 minutes and can last for up to eight hours. Many studies, some going as far back as the early 1980s out of Australia and the United Kingdom, both of which have had serious temazepam abuse epidemics and related mortality, have all mostly corroborated each other and proven that the potential for abuse and physical dependence is very high, even in comparison to many other benzodiazepines. As a result, prescriptions for hypnotics such as temazepam have seen a dramatic decrease since 2010, while anxiolytics such as alprazolam (Xanax), clonazepam, and lorazepam (Ativan) have increased or remained stable. Temazepam and similar hypnotics, such as triazolam (Halcion) are generally reserved for severe and debilitating insomnia. They have largely been replaced by z-drugs and atypical antidepressants as first line treatment for insomnia.

<span class="mw-page-title-main">Lorazepam</span> Benzodiazepine medication

Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication. It is used to treat anxiety, trouble sleeping, severe agitation, active seizures including status epilepticus, alcohol withdrawal, and chemotherapy-induced nausea and vomiting. It is also used during surgery to interfere with memory formation and to sedate those who are being mechanically ventilated. It is also used, along with other treatments, for acute coronary syndrome due to cocaine use. It can be given by mouth or as an injection into a muscle or vein. When given by injection, onset of effects is between one and thirty minutes and effects last for up to a day.

A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement. They are CNS depressants and interact with brain activity causing its deceleration. Various kinds of sedatives can be distinguished, but the majority of them affect the neurotransmitter gamma-aminobutyric acid (GABA). In spite of the fact that each sedative acts in its own way, most produce relaxing effects by increasing GABA activity.

<span class="mw-page-title-main">Triazolam</span> Triazolobenzodiazepine class medication

Triazolam, sold under the brand name Halcion among others, is a central nervous system (CNS) depressant tranquilizer of the triazolobenzodiazepine (TBZD) class, which are benzodiazepine (BZD) derivatives. It possesses pharmacological properties similar to those of other benzodiazepines, but it is generally only used as a sedative to treat severe insomnia. In addition to the hypnotic properties, triazolam's amnesic, anxiolytic, sedative, anticonvulsant, and muscle relaxant properties are pronounced as well.

<span class="mw-page-title-main">Midazolam</span> Benzodiazepine used for anesthesia and procedural sedation

Midazolam, sold under the brand name Versed among others, is a benzodiazepine medication used for anesthesia and procedural sedation, and to treat severe agitation. It induces sleepiness, decreases anxiety, and causes anterograde amnesia.

<span class="mw-page-title-main">Bromazepam</span> Benzodiazepine drug

Bromazepam, sold under many brand names, is a benzodiazepine. It is mainly an anti-anxiety agent with similar side effects to diazepam. In addition to being used to treat anxiety or panic states, bromazepam may be used as a premedicant prior to minor surgery. Bromazepam typically comes in doses of 3 mg and 6 mg tablets.

<span class="mw-page-title-main">Oxazepam</span> Benzodiazepine medication

Oxazepam is a short-to-intermediate-acting benzodiazepine. Oxazepam is used for the treatment of anxiety and insomnia and in the control of symptoms of alcohol withdrawal syndrome.

Psychomotor agitation is a symptom in various disorders and health conditions. It is characterized by unintentional and purposeless motions and restlessness, often but not always accompanied by emotional distress. Typical manifestations include pacing around, wringing of the hands, uncontrolled tongue movement, pulling off clothing and putting it back on, and other similar actions. In more severe cases, the motions may become harmful to the individual, and may involve things such as ripping, tearing, or chewing at the skin around one's fingernails, lips, or other body parts to the point of bleeding. Psychomotor agitation is typically found in various mental disorders, especially in psychotic and mood disorders. It can be a result of drug intoxication or withdrawal. It can also be caused by severe hyponatremia. The middle-aged and the elderly are more at risk to express it.

<span class="mw-page-title-main">Droperidol</span> Antidopaminergic drug

Droperidol is an antidopaminergic drug used as an antiemetic and as an antipsychotic. Droperidol is also often used as a rapid sedative in intensive-care treatment, and where "agitation aggression or violent behavior" are present.

<span class="mw-page-title-main">Asenapine</span> Medication to treat schizophrenia

Asenapine, sold under the brand name Saphris among others, is an atypical antipsychotic medication used to treat schizophrenia and acute mania associated with bipolar disorder as well as the medium to long-term management of bipolar disorder.

<span class="mw-page-title-main">Alcohol detoxification</span> Abrupt cessation of alcohol intake

Alcohol detoxification is the abrupt cessation of alcohol intake in individuals that have alcohol use disorder. This process is often coupled with substitution of drugs that have effects similar to the effects of alcohol in order to minimise alcohol withdrawal. When withdrawal does occur, it results in symptoms of varying severity.

<span class="mw-page-title-main">Tiapride</span> Antipsychotic medication

Tiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain. It is used to treat a variety of neurological and psychiatric disorders including dyskinesia, alcohol withdrawal syndrome, negative symptoms of psychosis, and agitation and aggression in the elderly. A derivative of benzamide, tiapride is chemically and functionally similar to other benzamide antipsychotics such as sulpiride and amisulpride known for their dopamine antagonist effects.

<span class="mw-page-title-main">Flutemazepam</span> Chemical compound

Flutemazepam was initially first synthesized in 1965, but was not further developed and described until a team at Stabilimenti Chimici Farmaceutici Riuniti SpA in the mid 1970s. It is the fluorinated analogue of temazepam that has powerful hypnotic, sedative, amnesiac, anxiolytic, anticonvulsant and skeletal muscle relaxant properties. It is most closely related in structure to temazepam, being the fluoro instead of chloro analogue. As a result, flutemazepam has been shown to have similar pharmacological properties to temazepam. It has been found to be effective for the treatment of the most severe states of anxiety, panic attacks, and severe insomnia. Furthermore, it is highly potent with 1 mg of flutemazepam being equivalent to 10 mg of diazepam. Flutemazepam is highly effective for acute psychotic states, especially stimulant psychosis, violent behaviour, and aggression.

Acute behavioral disturbance (ABD) is an umbrella term referring to various conditions of medical emergency where a person behaves in a manner that may put themselves or others at risk. It is not a formal diagnosis. Another controversial term, excited delirium, is sometimes used interchangeably with ABD.

<span class="mw-page-title-main">Bell's mania</span> Medical condition

Bell's mania, also known as delirious mania, refers to an acute neurobehavioral syndrome. This is usually characterized by an expeditious onset of delirium, mania, psychosis, followed by grandiosity, emotional lability, altered consciousness, hyperthermia, and in extreme cases, death. It is sometimes misdiagnosed as excited delirium (EXD) or catatonia due to the presence of overlapping symptoms. Pathophysiology studies reveal elevated dopamine levels in the neural circuit as the underlying mechanism. Psychostimulant users as well as individuals experiencing severe manic episodes are more prone to the manifestation of this condition. Management solutions such as sedation and ketamine injections have been discussed for medical professionals and individuals with the condition. Bell's mania cases are commonly reported in countries like the United States and Canada and are commonly associated with psychostimulant use and abuse.

References

  1. 1 2 3 4 Muir‐Cochrane, Eimear; Oster, Candice; Gerace, Adam; Dawson, Suzanne; Damarell, Raechel; Grimmer, Karen (2019-09-09). "The effectiveness of chemical restraint in managing acute agitation and aggression: A systematic review of randomized controlled trials". International Journal of Mental Health Nursing. Wiley. 29 (2): 110–126. doi:10.1111/inm.12654. ISSN   1445-8330. PMID   31498960. S2CID   202406529.
  2. 1 2 ""They Want Docile"". Human Rights Watch. 2018-02-05. Retrieved 2020-08-29.
  3. "Physical restraint, medication and seclusion of persons receiving care, education or supervision in a school, institution or facility". General Statutes of Connecticut - Title 46a* Human Rights. Connecticut General Assembly. January 1, 2011. Archived from the original on 2016-03-09. Retrieved 2014-11-18.
  4. OFDT (15 February 2011). "Juvenile Federal Performance-Based Detention Standards Handbook" (PDF). Department of Justice. Retrieved 2014-11-18.
  5. Fleisher, G.R.; Ludwig, S.; Henretig, F.M. (2006). Textbook of Pediatric Emergency Medicine. Vol. 355. Lippincott Williams & Wilkins. pp. 1–1812. ISBN   9780781750745 . Retrieved 2014-11-18.
  6. DiMaio, T.G.; DiMaio, V.J.M. (2005). Excited Delirium Syndrome: Cause of Death and Prevention. Taylor & Francis. p. 125. ISBN   9780203483473 . Retrieved 2014-11-18.
  7. "ABC World News: Deadly 'Chemical Restraints' Kill California Nursing Home Patients - ABC News". abcnews.go.com. Retrieved 2014-11-18.
  8. State of Connecticut (8 March 2007). "RESTRAINTS" (PDF). Retrieved 2014-11-18.
  9. O'Donnell, J.; Ahuja, G.D. (2005). Drug Injury: Liability, Analysis, and Prevention. Lawyers & Judges Publishing Company. pp. 1–723. ISBN   9780913875278 . Retrieved 2014-11-18.
  10. Nay, R.; Garratt, S. (2004). Nursing Older People: Issues and Innovations. Churchill Livingstone. p. 246. ISBN   9780729537513 . Retrieved 2014-11-18.