DNA-3-methyladenine glycosylase II

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DNA-3-methyladenine glycosylase II
Identifiers
EC no. 3.2.2.21
CAS no. 89287-38-7
Databases
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BRENDA BRENDA entry
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KEGG KEGG entry
MetaCyc metabolic pathway
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NCBI proteins

DNA-3-methyladenine glycosylase II (EC 3.2.2.21) is an enzyme [1] [2] [3] [4] that catalyses the following chemical reaction:

Contents

Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine, and 7-methyladenine

Involved in the removal of alkylated bases from DNA in Escherichia coli .

Evolution

Through the process of convergent evolution, there are at least two unrelated protein folds that share the same DNA-3-methyladenine glycosylase activity. The first, the AlkA N-terminal domain, is found in bacteria Pfam PF06029. The second, methylpurine-DNA glycosylase (MPG) Pfam PF02245 is found in vertebrates including humans. [5]

Nomenclature

DNA-3-methyladenine glycosylase II is also known as

See also

References

  1. ↑ Evensen G, Seeberg E (April 1982). "Adaptation to alkylation resistance involves the induction of a DNA glycosylase". Nature. 296 (5859): 773–775. Bibcode:1982Natur.296..773E. doi:10.1038/296773a0. PMID   7040984. S2CID   4318955.
  2. ↑ Karran P, Hjelmgren T, Lindahl T (April 1982). "Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents". Nature. 296 (5859): 770–773. Bibcode:1982Natur.296..770K. doi:10.1038/296770a0. PMID   7040983. S2CID   4367726.
  3. ↑ Riazuddin S, Lindahl T (May 1978). "Properties of 3-methyladenine-DNA glycosylase from Escherichia coli". Biochemistry. 17 (11): 2110–2118. doi:10.1021/bi00604a014. PMID   352392.
  4. ↑ Thomas L, Yang CH, Goldthwait DA (March 1982). "Two DNA glycosylases in Escherichia coli which release primarily 3-methyladenine". Biochemistry. 21 (6): 1162–1169. doi:10.1021/bi00535a009. PMID   7041972.
  5. ↑ Krokan HE, Bjørås M (April 2013). "Base excision repair". Cold Spring Harbor Perspectives in Biology. 5 (4) a012583. doi:10.1101/cshperspect.a012583. PMC   3683898 . PMID   23545420.


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