Geranyl diphosphate 2-C-methyltransferase

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Geranyl diphosphate 2-C-methyltransferase
Identifiers
EC no. 2.1.1.255
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Geranyl diphosphate 2-C-methyltransferase (EC 2.1.1.255, SCO7701, GPP methyltransferase, GPPMT, 2-methyl-GPP synthase, MGPPS, geranyl pyrophosphate methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:geranyl-diphosphate 2-C-methyltransferase. [1] [2] [3] [4] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + geranyl diphosphate S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate

This enzyme takes part in synthesis of 2-methylisoborneol.

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References

  1. ↑ Wang CM, Cane DE (July 2008). "Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor". Journal of the American Chemical Society. 130 (28): 8908–9. doi:10.1021/ja803639g. PMC   3023297 . PMID   18563898.
  2. ↑ Ariyawutthiphan O, Ose T, Tsuda M, Gao Y, Yao M, Minami A, Oikawa H, Tanaka I (March 2011). "Crystallization and preliminary X-ray crystallographic study of a methyltransferase involved in 2-methylisoborneol biosynthesis in Streptomyces lasaliensis". Acta Crystallographica Section F. 67 (Pt 3): 417–20. doi:10.1107/s1744309110051523. PMC   3053176 . PMID   21393856.
  3. ↑ Komatsu M, Tsuda M, Omura S, Oikawa H, Ikeda H (May 2008). "Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol". Proceedings of the National Academy of Sciences of the United States of America. 105 (21): 7422–7. doi: 10.1073/pnas.0802312105 . PMC   2387273 . PMID   18492804.
  4. ↑ Giglio S, Chou WK, Ikeda H, Cane DE, Monis PT (February 2011). "Biosynthesis of 2-methylisoborneol in cyanobacteria". Environmental Science & Technology. 45 (3): 992–8. doi:10.1021/es102992p. PMC   3699865 . PMID   21174459.
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