Glycine dehydrogenase (cyanide-forming)

glycine dehydrogenase (cyanide-forming)
Identifiers
EC no.	1.4.99.5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a glycine dehydrogenase (cyanide-forming) (EC 1.4.99.5) is an enzyme that catalyzes the chemical reaction

glycine + 2 A ⇌ hydrogen cyanide + CO₂ + 2 AH₂

Thus, the two substrates of this enzyme are glycine and A, whereas its 3 products are hydrogen cyanide, CO₂, and AH₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH₂ group of donors with other acceptors. The systematic name of this enzyme class is glycine:acceptor oxidoreductase (hydrogen-cyanide-forming). Other names in common use include hydrogen cyanide synthase, and HCN synthase.

References

• Wissing F (1975). "Cyanide production from glycine by a homogenate from a Pseudomonas species". J. Bacteriol. 121 (2): 695–9. doi:10.1128/jb.121.2.695-699.1975. PMC   245984 . PMID   234422.
• Castric PA (1977). "Glycine metabolism by Pseudomonas aeruginosa: hydrogen cyanide biosynthesis". J. Bacteriol. 130 (2): 826–31. doi:10.1128/jb.130.2.826-831.1977. PMC   235287 . PMID   233722.
• Haas D; Blumer, C; Von Schroetter, C; Gaia, V; Défago, G; Keel, C; Haas, D (1998). "Characterization of the hcnABC gene cluster encoding hydrogen cyanide synthase and anaerobic regulation by ANR in the strictly aerobic biocontrol agent Pseudomonas fluorescens CHA0". J. Bacteriol. 180 (12): 3187–96. doi:10.1128/JB.180.12.3187-3196.1998. PMC   107821 . PMID   9620970.
• Blumer C, Haas D (2000). "Mechanism, regulation, and ecological role of bacterial cyanide biosynthesis". Arch. Microbiol. 173 (3): 170–7. Bibcode:2000ArMic.173..170B. doi:10.1007/s002039900127. PMID   10763748.