Glycine formimidoyltransferase

glycine formimidoyltransferase
Identifiers
EC no.	2.1.2.4
CAS no.	9029-84-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a glycine formimidoyltransferase (EC 2.1.2.4) is an enzyme that catalyzes the chemical reaction

5-formimidoyltetrahydrofolate + glycine ${\displaystyle \rightleftharpoons }$ tetrahydrofolate + N-formimidoylglycine

Thus, the two substrates of this enzyme are 5-formimidoyltetrahydrofolate and glycine, whereas its two products are tetrahydrofolate and N-formimidoylglycine.

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase. Other names in common use include formiminoglycine formiminotransferase, FIG formiminotransferase, and glycine formiminotransferase. This enzyme participates in purine metabolism and one carbon pool by folate.

References

• Rabinowitz JC; Pricer WE (1956). "Formiminotetrahydrofolic acid and methenyltetrahydrofolic acid as intermediates in the formation of N10-formyltetrahydrofolic acid". J. Am. Chem. Soc. 78 (21): 5702–5704. Bibcode:1956JAChS..78.5702R. doi:10.1021/ja01602a073.
• Rabinowitz JC; Pricer WE (1957). "Formation, isolation and properties of 5-formiminotetrahydrofolic acid". Fed. Proc. 16: 236.
• Sagers RD, Beck JV, Gruber W, Gunsalus IC (1956). "A tetrahydrofolic acid linked formimino transfer enzyme". J. Am. Chem. Soc. 78 (3): 694–695. Bibcode:1956JAChS..78..694G. doi:10.1021/ja01584a054.