Glycine oxidase

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Glycine oxidase
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Glycine oxidase tetramer, Geobacillus kaustophilus
Identifiers
EC no. 1.4.3.19
CAS no. 39307-16-9
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BRENDA BRENDA entry
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MetaCyc metabolic pathway
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Glycine oxidase (EC 1.4.3.19) is an enzyme with systematic name glycine:oxygen oxidoreductase (deaminating). [1] [2] This enzyme catalyses the following chemical reaction

glycine + H2O + O2 glyoxylate + NH3 + H2O2 (overall reaction)
(1a) glycine + O2 2-iminoacetate + H2O2
(1b) 2-iminoacetate + H2O glyoxylate + NH3

This flavoenzyme containing non-covalently bound FAD.

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References

  1. Job V, Marcone GL, Pilone MS, Pollegioni L (March 2002). "Glycine oxidase from Bacillus subtilis. Characterization of a new flavoprotein". The Journal of Biological Chemistry. 277 (9): 6985–93. doi: 10.1074/jbc.M111095200 . PMID   11744710.
  2. Nishiya Y, Imanaka T (November 1998). "Purification and characterization of a novel glycine oxidase from Bacillus subtilis". FEBS Letters. 438 (3): 263–6. doi:10.1016/s0014-5793(98)01313-1. PMID   9827558.