Glycoside hydrolase family 30

Last updated
O-Glycosyl hydrolase family 30
PDB 1nof EBI.jpg
Structure of a xylanase from glycoside hydrolase family 5. [1]
Identifiers
SymbolGlyco_hydro_30
Pfam PF02055
Pfam clan CL0058
InterPro IPR001139
SCOP2 1nof / SCOPe / SUPFAM
OPM superfamily 117
OPM protein 1ogs
Available protein structures:
Pfam   structures / ECOD  
PDB RCSB PDB; PDBe; PDBj
PDBsum structure summary

In molecular biology, glycoside hydrolase family 30 is a family of glycoside hydrolases.[ citation needed ]

Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. [2] [3] [4] This classification is available on the CAZy web site, [5] [6] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes. [7] [8]

Glycoside hydrolase family 30 CAZY GH_30 includes the mammalian glucosylceramidases. Human acid beta-glucosidase (D-glucosyl-N-acylsphingosine glucohydrolase), cleaves the glucosidic bonds of glucosylceramide and synthetic beta-glucosides. [9] Any one of over 50 different mutations in the gene of glucocerebrosidase have been found to affect activity of this hydrolase, producing variants of Gaucher disease, the most prevalent lysosomal storage disease. [9] [10]

Related Research Articles

<span class="mw-page-title-main">Glycoside hydrolase family 1</span>

Glycoside hydrolase family 1 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

<span class="mw-page-title-main">Glycoside hydrolase family 10</span>

In molecular biology, Glycoside hydrolase family 10 is a family of glycoside hydrolases.

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In molecular biology, Glycoside hydrolase family 16 is a family of glycoside hydrolases.

<span class="mw-page-title-main">Glycoside hydrolase family 17</span>

In molecular biology, Glycoside hydrolase family 17 is a family of glycoside hydrolases. It folds into a TIM barrel.

<span class="mw-page-title-main">Glycoside hydrolase family 20</span>

In molecular biology, glycoside hydrolase family 20 is a family of glycoside hydrolases.

<span class="mw-page-title-main">Glycoside hydrolase family 3</span>

In molecular biology, glycoside hydrolase family 3 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of over 100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

<span class="mw-page-title-main">Glycoside hydrolase family 31</span>

In molecular biology, glycoside hydrolase family 31 is a family of glycoside hydrolases.

<span class="mw-page-title-main">Glycoside hydrolase family 35</span>

In molecular biology, glycoside hydrolase family 35 is a family of glycoside hydrolases.

<span class="mw-page-title-main">Glycoside hydrolase family 39</span> Family of glycoside hydrolases

In molecular biology, glycoside hydrolase family 39 is a family of glycoside hydrolases.

<span class="mw-page-title-main">Glycoside hydrolase family 4</span>

In molecular biology, glycoside hydrolase family 4 is a family of glycoside hydrolases EC 3.2.1., which are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

<span class="mw-page-title-main">Glycoside hydrolase family 46</span>

In molecular biology, glycoside hydrolase family 46 is a family of glycoside hydrolases.

<span class="mw-page-title-main">Glycoside hydrolase family 53</span>

In molecular biology, the glycoside hydrolase family 53 is a family of glycoside hydrolases EC 3.2.1., which are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 63 is a family of glycoside hydrolases.

<span class="mw-page-title-main">Glycoside hydrolase family 68</span>

In molecular biology, glycoside hydrolase family 68 is a family of glycoside hydrolases.

<span class="mw-page-title-main">Glycoside hydrolase family 7</span> Enzyme family

In molecular biology, glycoside hydrolase family 7 is a family of glycoside hydrolases EC 3.2.1., which are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 81 is a family of glycoside hydrolases.

In molecular biology, glycoside hydrolase family 85 is a family of glycoside hydrolases.

In molecular biology, glycoside hydrolase family 97 is a family of glycoside hydrolases.

In molecular biology, glycoside hydrolase family 6 is a family of glycoside hydrolases EC 3.2.1., which are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 15 is a family of glycoside hydrolases.

References

  1. Larson SB, Day J, Barba de la Rosa AP, Keen NT, McPherson A (July 2003). "First crystallographic structure of a xylanase from glycoside hydrolase family 5: implications for catalysis". Biochemistry. 42 (28): 8411–22. doi:10.1021/bi034144c. PMID   12859186.
  2. Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G (July 1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proceedings of the National Academy of Sciences of the United States of America. 92 (15): 7090–4. Bibcode:1995PNAS...92.7090H. doi: 10.1073/pnas.92.15.7090 . PMC   41477 . PMID   7624375.
  3. Davies G, Henrissat B (September 1995). "Structures and mechanisms of glycosyl hydrolases". Structure. 3 (9): 853–9. doi: 10.1016/S0969-2126(01)00220-9 . PMID   8535779.
  4. Henrissat B, Bairoch A (June 1996). "Updating the sequence-based classification of glycosyl hydrolases". The Biochemical Journal. 316 (Pt 2): 695–6. doi:10.1042/bj3160695. PMC   1217404 . PMID   8687420.
  5. "Home". CAZy.org. Retrieved 2018-03-06.
  6. Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B (January 2014). "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research. 42 (Database issue): D490-5. doi:10.1093/nar/gkt1178. PMC   3965031 . PMID   24270786.
  7. "Glycoside Hydrolase Family 30". CAZypedia.org. Retrieved 2018-03-06.
  8. CAZypedia Consortium (December 2018). "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes". Glycobiology. 28 (1): 3–8. doi: 10.1093/glycob/cwx089 . PMID   29040563.
  9. 1 2 Dinur T, Osiecki KM, Legler G, Gatt S, Desnick RJ, Grabowski GA (March 1986). "Human acid beta-glucosidase: isolation and amino acid sequence of a peptide containing the catalytic site". Proceedings of the National Academy of Sciences of the United States of America. 83 (6): 1660–4. Bibcode:1986PNAS...83.1660D. doi: 10.1073/pnas.83.6.1660 . PMC   323143 . PMID   3456607.
  10. Iwasawa K, Ida H, Eto Y (August 1997). "Differences in origin of the 1448C mutation in patients with Gaucher disease". Acta Paediatrica Japonica. 39 (4): 451–3. doi:10.1111/j.1442-200x.1997.tb03616.x. PMID   9316290. S2CID   26851772.