HDAC11

HDAC11
Identifiers
Aliases	HDAC11 , HD11, histone deacetylase 11
External IDs	OMIM: 607226; MGI: 2385252; HomoloGene: 11743; GeneCards: HDAC11; OMA:HDAC11 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p25.1 Start 13,479,724 bp [1] End 13,506,424 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 D1 Start 91,133,647 bp [2] End 91,151,674 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis inferior ganglion of vagus nerve right testis putamen amygdala caudate nucleus C1 segment nucleus accumbens prefrontal cortex globus pallidus Top expressed in dorsomedial hypothalamic nucleus superior colliculus dorsal tegmental nucleus ventral tegmental area lateral hypothalamus paraventricular nucleus of hypothalamus anterior amygdaloid area ventromedial nucleus central gray substance of midbrain Region I of hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function NAD-dependent histone deacetylase activity (H3-K14 specific) transcription factor binding hydrolase activity histone deacetylase activity protein binding Cellular component histone deacetylase complex plasma membrane nucleus Biological process histone H3 deacetylation oligodendrocyte development regulation of transcription, DNA-templated histone deacetylation transcription, DNA-templated chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79885 232232 Ensembl ENSG00000163517 ENSMUSG00000034245 UniProt Q96DB2 Q91WA3 RefSeq (mRNA) NM_001136041 NM_024827 NM_001330636 NM_144919 RefSeq (protein) NP_001129513 NP_001317565 NP_079103 NP_659168 Location (UCSC) Chr 3: 13.48 – 13.51 Mb Chr 6: 91.13 – 91.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Histone deacetylase 11 is a 39kDa histone deacetylase enzyme that in humans is encoded by the HDAC11 gene on chromosome 3 in humans and chromosome 6 in mice. ^{[5] [6]}

It is the only Class IV HDAC since it is not highly homologous with either Rpd3 or hda1 yeast enzymes and so does not fit into either Class I or Class II. ^[7] It is the smallest HDAC isoform and it was first described in 2002.

Function

Histone deacetylases, such as HDAC11, control DNA expression by modifying the core histone octamers that package DNA into dense chromatin structures and repress gene expression.[supplied by OMIM] ^[6]

HDAC11 expression is normally found in brain and testis tissue, but upregulation of HDAC11 expression has also been seen in various cancer cells.

HDAC11 has been shown to be a negative regulator of IL-10 production in antigen presenting cells. It has also been shown that inhibition of HDAC11 results in increased expression of OX40L in Hodgkin lymphoma cells.

Interactions

HDAC11 has been shown to interact with HDAC6. ^[5]

See also

• Histone deacetylase

References

1. GRCh38: Ensembl release 89: ENSG00000163517 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034245 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gao L, Cueto MA, Asselbergs F, Atadja P (Jul 2002). "Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family". The Journal of Biological Chemistry. 277 (28): 25748–55. doi: 10.1074/jbc.M111871200 . PMID   11948178. S2CID   20332854.
6. "Entrez Gene: HDAC11 histone deacetylase 11".
7. Yang XJ, Seto E (Mar 2008). "The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men". Nature Reviews Molecular Cell Biology. 9 (3): 206–18. doi:10.1038/nrm2346. PMC   2667380 . PMID   18292778.

Further reading

• Verdin E, Dequiedt F, Kasler HG (May 2003). "Class II histone deacetylases: versatile regulators". Trends in Genetics. 19 (5): 286–93. doi:10.1016/S0168-9525(03)00073-8. hdl: 2268/80861 . PMID   12711221.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Voelter-Mahlknecht S, Ho AD, Mahlknecht U (Oct 2005). "Chromosomal organization and localization of the novel class IV human histone deacetylase 11 gene". International Journal of Molecular Medicine. 16 (4): 589–98. doi:10.3892/ijmm.16.4.589 (inactive 2024-09-13). PMID   16142391.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Lindberg D, Akerström G, Westin G (Jan 2007). "Mutational analyses of WNT7A and HDAC11 as candidate tumour suppressor genes in sporadic malignant pancreatic endocrine tumours". Clinical Endocrinology. 66 (1): 110–4. doi:10.1111/j.1365-2265.2006.02694.x. PMID   17201809. S2CID   21975021.

External links

• HDAC11+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.