HDAC11

Last updated
HDAC11
Identifiers
Aliases HDAC11 , HD11, histone deacetylase 11
External IDs OMIM: 607226 MGI: 2385252 HomoloGene: 11743 GeneCards: HDAC11
Orthologs
SpeciesHumanMouse
Entrez

79885

232232

Ensembl

ENSG00000163517

ENSMUSG00000034245

UniProt

Q96DB2

Q91WA3

RefSeq (mRNA)

NM_001136041
NM_024827
NM_001330636

NM_144919

RefSeq (protein)

NP_001129513
NP_001317565
NP_079103

NP_659168

Location (UCSC) Chr 3: 13.48 – 13.51 Mb Chr 6: 91.13 – 91.15 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Histone deacetylase 11 is a 39kDa histone deacetylase enzyme that in humans is encoded by the HDAC11 gene on chromosome 3 in humans and chromosome 6 in mice. [5] [6]

Contents

It is the only Class IV HDAC since it is not highly homologous with either Rpd3 or hda1 yeast enzymes and so does not fit into either Class I or Class II. [7] It is the smallest HDAC isoform and it was first described in 2002.

Function

Histone deacetylases, such as HDAC11, control DNA expression by modifying the core histone octamers that package DNA into dense chromatin structures and repress gene expression.[supplied by OMIM] [6]

HDAC11 expression is normally found in brain and testis tissue, but upregulation of HDAC11 expression has also been seen in various cancer cells.

HDAC11 has been shown to be a negative regulator of IL-10 production in antigen presenting cells. It has also been shown that inhibition of HDAC11 results in increased expression of OX40L in Hodgkin lymphoma cells.

Interactions

HDAC11 has been shown to interact with HDAC6. [5]

See also

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000163517 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034245 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Gao L, Cueto MA, Asselbergs F, Atadja P (Jul 2002). "Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family". The Journal of Biological Chemistry. 277 (28): 25748–55. doi: 10.1074/jbc.M111871200 . PMID   11948178. S2CID   20332854.
  6. 1 2 "Entrez Gene: HDAC11 histone deacetylase 11".
  7. ↑ Yang XJ, Seto E (Mar 2008). "The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men". Nature Reviews Molecular Cell Biology. 9 (3): 206–18. doi:10.1038/nrm2346. PMC   2667380 . PMID   18292778.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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