Histidine—tRNA ligase

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histidine-tRNA ligase
Identifiers
EC no. 6.1.1.21
CAS no. 9068-78-4
Alt. nameshistidyl tRNA synthetase, Jo-1
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BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
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In enzymology, a histidine-tRNA ligase (EC 6.1.1.21) is an enzyme that catalyzes the chemical reaction

Contents

ATP + L-histidine + tRNAHis AMP + diphosphate + L-histidyl-tRNAHis

The 3 substrates of this enzyme are ATP, L-histidine, and tRNA(His), whereas its 3 products are AMP, diphosphate, and L-histidyl-tRNA(His).

This enzyme participates in histidine metabolism and aminoacyl-trna biosynthesis.

Nomenclature

Histidine—tRNA ligase belongs to the family of ligase enzymes, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-histidine:tRNAHis ligase (AMP-forming). Other names in common use include histidyl-tRNA synthetase, histidyl-transfer ribonucleate synthetase, and histidine translase.

See also

Related Research Articles

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References


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