Hymenolepis (flatworm)

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Hymenolepis
Hymenolepis diminuta scolex.jpg
Anterior end of rat tapeworm adult (Hymenolepis diminuta)
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Eukaryota
Kingdom: Animalia
Phylum: Platyhelminthes
Class: Cestoda
Order: Cyclophyllidea
Family: Hymenolepididae
Genus: Hymenolepis
Weinland, 1858

Hymenolepis is a genus of cyclophyllid tapeworms that cause hymenolepiasis. They parasitise mammals, including humans. Some notable species are:

Contents

Disease

Signs and symptoms

Most infected humans have a low number of worms and therefore are asymptomatic. Patients with more than 15,000 eggs per gram of stool may experience cramps, diarrhea, irritability, anorexia, or enteritis caused by cystercoids destroying the intestinal villi in which they develop. [1]

Diagnosis

Diagnosis for hymenolepiasis is done by examining stool for eggs. The proglottids that are disintegrated in the intestine cannot be detected. Egg output can be sporadic so a couple of stool tests a few days apart may be needed to diagnose the infection. [ citation needed ]

Treatment

Different Hymenolepis spp. can be treated with different anthelmintics. These treatments include albendazole, niclosamide, and praziquantel. [2]

Epidemiology

Prevalence of Hymenolepis infections in endemic areas can reach 20%. [1] H. nana is the most common cestode in humans with infection prevalence highest among children and in warm arid climates with poor sanitation facilities. [1] Case studies from different continents suggest that H. nana is difficult to eliminate. The prevalence of H. nana in remote communities in northwest Australia is very high, 55%. The transmission is due mostly from human to human contact and auto-infection. [3] In Bat Dambang, Cambodia, middle school students were found to have higher Hymenolepis prevalence than younger children, suggesting children are not learning prevention techniques as they mature. [4] Turkish children living shanty towns have higher prevalence than those in school provide apartments, with similar infection rates between boys and girls. [5] In rural Mexico, 25% of the children aged 6–10 in twelve schools were infected with H. nana. Socio-economic factors and lack of parent education are strong influences on the high prevalence rate. [ citation needed ] While in Zimbabwe, H. nana infections occur in children in small towns and high-density suburbs. Infections are more frequent in younger children who live in urban areas and in older children who live in rural locations. Overall prevalence was 24% in urban areas, and 18% in rural towns. [6] In a study of six communities along the banks of Lake Titicaca, the prevalence of H. nana was 6.6%. The overall intestinal pathogenic infection prevalence rate was 91.2%, with many subjects having up to 5 different types of parasites. [7]

Biology

Hymenolepiasis is the most common cestode infection in humans, children are more commonly infected than adults. It is most widespread in warm climates. Under unsanitary conditions, eggs can be passed through faecal matter from an infected person to uninfected persons.

Hymenolepiasis is caused by either H. nana or H. diminuta. A member of the cestode class, tapeworms do not have digestive tracts to absorb nutrients, instead their surface body layer is metabolically active with nutrients and waste passing in and out continuously. In contrast, the nematodes class, such as hookworms, have complete digestive tracts and separate orifices for food ingestion and waste excretion. Although the cestode life cycle requires the cysticercoid, or larval, phase to be developed in an intermediate host, H. nana does not follow this observation and can use an intermediate host or auto infect the human host.

Life cycle

Like many cestodes, Hymonolepis spp. generally have a life cycle including an intermediate and a definitive host. Intermediate host species include rodents and beetles. Hymenolepis nana can, however, either use an intermediate host, such as a rat, or be transmitted directly from human to human. This indicates that this species is in the process of evolving an abbreviate life cycle. [8]

Human infection can occur through the ingestion of eggs with food or water, or through ingestion of contaminated cereal of flour containing infected beetles. Furthermore, infections could arise from infected pets from pet stores. [9]

Morphology

Hymenolepis nana worms are flat and segmented with skinny necks. They vary in length from approximately 15 to 40 mm and are 1 mm wide. Each worm has a scolex, which is an anterior ‘head’ segment with a single row of 20-30 retractable hooks (rostellum). Each worm also has proglottids, which are wider segments of the tapeworm that contains both male and female reproductive organs. [1] Each mature segment has unilateral genital pores and 3 testes. When the eggs have been fertilized the segments are referred to as gravid. These break off from the main portion, the strobila, and deteriorate releasing eggs. The oncospheres, or embryos, can be from 30-47 µm in diameter and are covered with a thin hyaline outer membrane and a thicker inner membrane. Embedded in the inner membrane on polar sides of the oncosphere are a number of hair-like filaments. [1]

Hymenolepis diminuta worms are the same shape as H. nana but are much larger, up to 90 cm long and 44 mm wide. Their scolex does not have hooked rostellum like the H. nana species but they do have similar unilateral genital pores and 3 testes per proglottid. The oncospheres of H. diminuta are similar to H. nana’s except they lack hair like filaments embedded in their inner membrane and are two times their size. [1]

History

Hymenolepis nana was first identified as a human parasite by Von Siebold in 1852. In 1906, Stiles identified an identical parasite with a rodent host and named it Hymenolepis fraterna. Later, morphological characteristics were used for taxonomy identification and H. nana was known to have hooks and linear reproductive organs. H. diminuta has no hooks and reproductive organs arranged in a triangular formation. [1]

Related Research Articles

<i>Diphyllobothrium</i> Genus of flatworms

Diphyllobothrium is a genus of tapeworms which can cause diphyllobothriasis in humans through consumption of raw or undercooked fish. The principal species causing diphyllobothriasis is D. latum, known as the broad or fish tapeworm, or broad fish tapeworm. D. latum is a pseudophyllid cestode that infects fish and mammals. D. latum is native to Scandinavia, western Russia, and the Baltics, though it is now also present in North America, especially the Pacific Northwest. In Far East Russia, D. klebanovskii, having Pacific salmon as its second intermediate host, was identified.

Hymenolepiasis is infestation by one of two species of tapeworm: Hymenolepis nana or H. diminuta. Alternative names are dwarf tapeworm infection and rat tapeworm infection. The disease is a type of helminthiasis which is classified as a neglected tropical disease.

<i>Taenia solium</i> Species of Cestoda

Taenia solium, the pork tapeworm, belongs to the cyclophyllid cestode family Taeniidae. It is found throughout the world and is most common in countries where pork is eaten. It is a tapeworm that uses humans as its definitive host and pigs as the intermediate or secondary hosts. It is transmitted to pigs through human feces that contain the parasite eggs and contaminate their fodder. Pigs ingest the eggs, which develop into larvae, then into oncospheres, and ultimately into infective tapeworm cysts, called cysticercus. Humans acquire the cysts through consumption of uncooked or under-cooked pork and the cysts grow into an adult worms in the small intestine.

<i>Taenia</i> (flatworm) Genus of flatworms

Taenia is the type genus of the Taeniidae family of tapeworms. It includes some important parasites of livestock. Members of the genus are responsible for taeniasis and cysticercosis in humans, which are types of helminthiasis belonging to the group of neglected tropical diseases. More than 100 species are recorded. They are morphologically characterized by a ribbon-like body composed of a series of segments called proglottids; hence the name Taenia. The anterior end of the body is the scolex. Some members of the genus Taenia have an armed scolex ; of the two major human parasites, Taenia saginata has an unarmed scolex, while Taenia solium has an armed scolex.

<i>Taenia saginata</i> Species of flatworm

Taenia saginata, commonly known as the beef tapeworm, is a zoonotic tapeworm belonging to the order Cyclophyllidea and genus Taenia. It is an intestinal parasite in humans causing taeniasis and cysticercosis in cattle. Cattle are the intermediate hosts, where larval development occurs, while humans are definitive hosts harbouring the adult worms. It is found globally and most prevalently where cattle are raised and beef is consumed. It is relatively common in Africa, Europe, Southeast Asia, South Asia, and Latin America. Humans are generally infected as a result of eating raw or undercooked beef which contains the infective larvae, called cysticerci. As hermaphrodites, each body segment called proglottid has complete sets of both male and female reproductive systems. Thus, reproduction is by self-fertilisation. From humans, embryonated eggs, called oncospheres, are released with faeces and are transmitted to cattle through contaminated fodder. Oncospheres develop inside muscle, liver, and lungs of cattle into infective cysticerci.

<i>Dipylidium caninum</i> Species of flatworm

Dipylidium caninum, also called the flea tapeworm, double-pored tapeworm, or cucumber tapeworm is a cyclophyllid cestode that infects organisms afflicted with fleas and canine chewing lice, including dogs, cats, and sometimes human pet-owners, especially children.

<span class="mw-page-title-main">Hymenolepididae</span> Family of flatworms

The Hymenolepididae are family of cyclophyllid tapeworms. Their characteristic feature is the small number of testes. The unilateral genital pores and large external seminal vesicle allow for easy recognition. Most species are small, transparent, and easy to study. The family contains over 90 genera with over 900 species, having as their definitive host birds or mammals. Most reside in the intestines of their definitive hosts. The majority of species with known lifecycles have arthropods as intermediate hosts.

<i>Hymenolepis nana</i> Species of flatworm

Dwarf tapeworm is a cosmopolitan species though most common in temperate zones, and is one of the most common cestodes infecting humans, especially children.

<i>Hymenolepis diminuta</i> Species of flatworm

Hymenolepis diminuta, also known as rat tapeworm, is a species of Hymenolepis tapeworm that causes hymenolepiasis. It has slightly bigger eggs and proglottids than H. nana and infects mammals using insects as intermediate hosts. The adult structure is 20 to 60 cm long and the mature proglottid is similar to that of H. nana, except it is larger.

<i>Taenia pisiformis</i> Species of flatworm

Taenia pisiformis, commonly called the rabbit tapeworm, is an endoparasitic tapeworm which causes infection in lagomorphs, rodents, and carnivores. Adult T. pisiformis typically occur within the small intestines of the definitive hosts, the carnivores. Lagomorphs, the intermediate hosts, are infected by fecal contamination of grasses and other food sources by the definitive hosts. The larval stage is often referred to as Cysticercus pisiformis and is found on the livers and peritoneal cavities of the intermediate hosts. T. pisiformis can be found worldwide.

<span class="mw-page-title-main">Eucestoda</span> Subclass of flatworms

Eucestoda, commonly referred to as tapeworms, is the larger of the two subclasses of flatworms in the class Cestoda. Larvae have six posterior hooks on the scolex (head), in contrast to the ten-hooked Cestodaria. All tapeworms are endoparasites of vertebrates, living in the digestive tract or related ducts. Examples are the pork tapeworm with a human definitive host, and pigs as the secondary host, and Moniezia expansa, the definitive hosts of which are ruminants.

<span class="mw-page-title-main">Cestoda</span> Class of flatworms

Cestoda is a class of parasitic worms in the flatworm phylum (Platyhelminthes). Most of the species—and the best-known—are those in the subclass Eucestoda; they are ribbon-like worms as adults, known as tapeworms. Their bodies consist of many similar units known as proglottids—essentially packages of eggs which are regularly shed into the environment to infect other organisms. Species of the other subclass, Cestodaria, are mainly fish infecting parasites.

Diphyllobothrium mansonoides is a species of tapeworm (cestodes) that is endemic to North America. Infection with D. mansonoides in humans can result in sparganosis. Justus F. Mueller first reported this organism in 1935. D. mansonoides is similar to D. latum and Spirometra erinacei. When the organism was discovered, scientist did not know if D. mansonoides and S. erinacei were separate species. PCR analysis of the two worms has shown the two to be separate but closely related organisms.

Bertielliasis is the infection of Bertiella, a cestode tapeworm parasite that primarily infects nonhuman primates, rodents and Australian marsupials. Occasionally, human infections have been documented by one of two species: Bertiella studeri, or Bertiella mucronata. Of 29 different Bertiella species, only these two can infect humans.

<i>Raillietina</i> Genus of flatworms

Raillietina is a genus of tapeworms that includes helminth parasites of vertebrates, mostly of birds. The genus was named in 1920 in honour of a French veterinarian and helminthologist, Louis-Joseph Alcide Railliet. Of the 37 species recorded under the genus, Raillietina demerariensis, R. asiatica, and R. formsana are the only species reported from humans, while the rest are found in birds. R. echinobothrida, R. tetragona, and R. cesticillus are the most important species in terms of prevalence and pathogenicity among wild and domestic birds.

Taenia asiatica, commonly known as Asian taenia or Asian tapeworm, is a parasitic tapeworm of humans and pigs. It is one of the three species of Taenia infecting humans and causes taeniasis. Discovered only in 1980s from Taiwan and other East Asian countries as an unusual species, it is so notoriously similar to Taenia saginata, the beef tapeworm, that it was for a time regarded as a slightly different strain. But anomaly arose as the tapeworm is not of cattle origin, but of pigs. Morphological details also showed significant variations, such as presence of rostellar hooks, shorter body, and fewer body segments. The scientific name designated was then Asian T. saginata. But the taxonomic consensus turns out to be that it is a unique species. It was in 1993 that two Korean parasitologists, Keeseon S. Eom and Han Jong Rim, provided the biological bases for classifying it into a separate species. The use of mitochondrial genome sequence and molecular phylogeny in the late 2000s established the taxonomic status.

Moniezia expansa is commonly known as sheep tapeworm or double-pored ruminant tapeworm. It is a large tapeworm inhabiting the small intestines of ruminants such as sheep, goats and cattle. It has been reported from Peru that pigs are also infected. There is an unusual report of human infection in an Egyptian. It is characterized by unarmed scolex, presence of two sets of reproductive systems in each proglottid, and each proglottid being very short but very broad.

<i>Hymenolepis microstoma</i> Species of flatworm

Hymenolepis microstoma, also known as the rodent tapeworm, is an intestinal dwelling parasite. Adult worms live in the bile duct and small intestines of mice and rats, and larvae metamorphose in the haemocoel of beetles. It belongs to the genus Hymenolepis; tapeworms that cause hymenolepiasis. H. microstoma is prevalent in rodents worldwide, but rarely infects humans.

<i>Raillietina tetragona</i> Species of flatworm

Raillietina tetragona is a parasitic tapeworm belonging to the class Cestoda. It is a cosmopolitan helminth of the small intestine of pigeon, chicken and guinea fowl, and is found throughout the world.

Raillietina cesticillus is a parasitic tapeworm of the family Davaineidae. Sometimes called "Broad-headed tapeworm", it infects the small intestine of chicken and occasionally other birds, such as guinea fowl and turkey, which are generally in close proximity to backyard poultry. It is a relatively harmless species among intestinal cestodes in spite of a high prevalence. In fact it probably is the most common parasitic platyhelminth in modern poultry facilities throughout the world.

References

  1. 1 2 3 4 5 6 7 Schantz, P.M. (1996). "Tapeworms (Cestodiasis)". Gastroenterology Clinics of North America . 25 (3): 637–653. doi:10.1016/s0889-8553(05)70267-3. PMID   8863044.
  2. Khan, W.; Khan, J.; Rahman, A.; Ullah, H.; Salim, M.; Iqbal, M.; Khan, I.; Salman, M.; Munir, B. (2018). "Albendazole in the treatment of Hymenolepiasis in school children". Pakistan Journal of Pharmaceutical Sciences . 31 (1(Suppl.)): 305–309. PMID   29386158.
  3. Macnish, M.G. (2001). Characterisation of community-derived Hymenolepis infections in Australia.
  4. Park, S.K.; Kim, D.-H.; Deung, Y.-K.; Kim, H.-J.; Yang, E.-J.; Lim, S.-J.; Ryang, Y.-S.; Jin, D.; Lee, K.-J. (2004). "Status of intestinal parasite infections among children in Bat Dambang, Cambodia". The Korean Journal of Parasitology . 42 (4): 201–203. doi:10.3347/kjp.2004.42.4.201. PMC   2717386 . PMID   15591838.
  5. Ulukanligil, M.; Seyrek, A. (2004). "Anthropometric status, anaemia and intestinal helminthic infections in shantytown and apartment schoolchildren in the Sanliurfa province of Turkey". European Journal of Clinical Nutrition . 58 (7): 1056–1061. doi:10.1038/sj.ejcn.1601932. PMID   15220948. S2CID   23914237.
  6. Mason, P. R.; Patterson, B. A. (1994). "Epidemiology of Hymenolepis nana infections in primary school children in urban and rural communities in Zimbabwe". The Journal of Parasitology . 80 (2): 245–250. doi:10.2307/3283754. JSTOR   3283754. PMID   8158468.
  7. Quihui, L.; Valencia, M.E; Crompton, D.W.T; Phillips, S.; Hagan, P.; Morales, G.; Díaz-Camacho, S.P (2006). "Role of the employment status and education of mothers in the prevalence of intestinal parasitic infections in Mexican rural schoolchildren". BMC Public Health. 6 (1): 225. doi: 10.1186/1471-2458-6-225 . PMC   1584408 . PMID   16956417.
  8. Poulin, R.; Cribb, T.H. (2002). "Trematode life cycles: short is sweet?". Trends in Parasitology. 18 (4): 176–183. doi:10.1016/s1471-4922(02)02262-6. PMID   11998706.
  9. Jarošová, J.; Antolová, D.; Šnábel, V.; Miklisová, D.; Cavallero, S. (2020). "The dwarf tapeworm Hymenolepis nana in pet rodents in Slovakia—epidemiological survey and genetic analysis". Parasitology Research . 119 (2): 519–527. doi:10.1007/s00436-019-06565-7. PMID   31848746. S2CID   209392649.

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