Hypochloremia

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Hypochloremia
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Chlorine
Specialty Endocrinology   OOjs UI icon edit-ltr-progressive.svg
Complications Metabolic alkalosis [1]
Causes Vomiting, Diuretics [2]
TreatmentTreat underlying cause, salt and fluid intake[ citation needed ]

Hypochloremia (or Hypochloraemia) is an electrolyte disturbance in which there is an abnormally low level of the chloride ion in the blood. Normal serum range for chloride is 97 to 107 mmol/L with levels less than 96 mmol/L defining hypochloremia. [3]

Contents

Hypochloremia can contribute to metabolic alkalosis. Patients with mild hypochloremia may be asymptomatic. In significant chloride depletion and the resulting alkalosis, symptoms may include neuromuscular irritability, such as muscle cramps, twitching, and, in severe cases, seizures. [1]

Treatment involves diagnosing the underlying cause. Mild hypochloremia may be corrected by salt intake. For more severe hypochloremia, IV fluids may be given.[ citation needed ]

It rarely occurs in the absence of other abnormalities. It is sometimes associated with hypoventilation. [4] It can be associated with chronic respiratory acidosis. [5] If it occurs together with metabolic alkalosis (decreased blood acidity) it is often due to vomiting. [2] It is usually the result of hyponatremia or elevated bicarbonate concentration. It occurs in cystic fibrosis. [6]

Causes

Gastrointestinal causes

Renal causes

Other causes

References

  1. 1 2 3 Sagar, Nandin; Lohiya, Sham (March 2024). "A Comprehensive Review of Chloride Management in Critically Ill Patients". Cureus. 16 (3): e55625. doi: 10.7759/cureus.55625 . ISSN   2168-8184. PMC   10995984 . PMID   38586759.
  2. 1 2 3 4 5 6 7 Berend, Kenrick; van Hulsteijn, Leonard Hendrik; Gans, Rijk O. B. (April 2012). "Chloride: the queen of electrolytes?". European Journal of Internal Medicine. 23 (3): 203–211. doi:10.1016/j.ejim.2011.11.013. ISSN   1879-0828. PMID   22385875.
  3. Pfortmueller, Carmen Andrea; Uehlinger, Dominik; von Haehling, Stephan; Schefold, Joerg Christian (April 2018). "Serum chloride levels in critical illness—the hidden story". Intensive Care Medicine Experimental. 6 (1): 10. doi: 10.1186/s40635-018-0174-5 . ISSN   2197-425X. PMC   5899079 . PMID   29654387.
  4. Lavie CJ, Crocker EF, Key KJ, Ferguson TG (October 1986). "Marked hypochloremic metabolic alkalosis with severe compensatory hypoventilation". South. Med. J. 79 (10): 1296–9. doi:10.1097/00007611-198610000-00025. PMID   3764530.
  5. 1 2 Levitin H, Branscome W, Epstein FH (December 1958). "The pathogenesis of hypochloremia in respiratory acidosis". J. Clin. Invest. 37 (12): 1667–75. doi:10.1172/JCI103758. PMC   1062852 . PMID   13611033.
  6. 1 2 Scurati-Manzoni, Elisabetta; Fossali, Emilio F.; Agostoni, Carlo; Riva, Enrica; Simonetti, Giacomo D.; Zanolari-Calderari, Maura; Bianchetti, Mario G.; Lava, Sebastiano A. G. (June 2014). "Electrolyte abnormalities in cystic fibrosis: systematic review of the literature" . Pediatric Nephrology. 29 (6): 1015–1023. doi:10.1007/s00467-013-2712-4. ISSN   0931-041X. PMID   24326787.
  7. Abdullah AM, Shaheed MM, Katugampola SM, Patel PJ (March 1990). "Congenital chloride diarrhoea: case report and review of the literature". Annals of Tropical Paediatrics. 10 (1): 71–4. doi:10.1080/02724936.1990.11747412. PMID   1694648.