Marneral synthase

Marneral synthase
Identifiers
EC no.	5.4.99.53
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Marneral synthase (EC 5.4.99.53) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, marneral-forming). ^[1] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene ${\displaystyle \rightleftharpoons }$ marneral

Marneral is a triterpenoid formed by Grob fragmentation of the A ring of 2,3-epoxy-2,3-dihydrosqualene during cyclization. This aldehyde gains its name from its structural similarity to a class triterpenes commonly found in members of the Iridaceae, originally identified by Dr. Franz-Josef Marner ^[1]

This enzyme is a member of a metabolic gene cluster along with two other cytochrome P450s. ^[2]

References

1. Xiong Q, Wilson WK, Matsuda SP (February 2006). "An Arabidopsis oxidosqualene cyclase catalyzes iridal skeleton formation by Grob fragmentation". Angewandte Chemie. 45 (8): 1285–8. doi:10.1002/anie.200503420. PMID   16425307.
2. Field B, Fiston-Lavier AS, Kemen A, Geisler K, Quesneville H, Osbourn AE (September 2011). "Formation of plant metabolic gene clusters within dynamic chromosomal regions". Proceedings of the National Academy of Sciences of the United States of America. 108 (38): 16116–21. Bibcode:2011PNAS..10816116F. doi: 10.1073/pnas.1109273108 . PMC   3179108 . PMID   21876149.

External links

• Marneral+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)