| Middle East blind mole-rat | |
|---|---|
 | |
Scientific classification  | |
| Domain: | Eukaryota |
| Kingdom: | Animalia |
| Phylum: | Chordata |
| Class: | Mammalia |
| Order: | Rodentia |
| Family: | Spalacidae |
| Genus: | Nannospalax |
| Species: | N. ehrenbergi |
| Binomial name | |
| Nannospalax ehrenbergi (Nehring, 1898) | |
| Synonyms | |
Spalax ehrenbergi Contents | |
The Middle East blind mole-rat or Palestine mole-rat (Nannospalax ehrenbergi) is a species of rodent in the family Spalacidae. [2]
It was formerly classified in the genus Spalax , but more recent phylogenetic evidence supports it and two other species belonging to the genus Nannospalax . Of the three Nannospalax species, N. ehrenbergi is the only one to also belong to the subgenus Nannospalax (unless the potential species within N. ehrenbergi are also considered their own species). [3]
Cytogenetic studies have shown N. ehrenbergi in Israel may actually be a species complex containing several cryptic species with chromosome numbers 2n=52, 2n=54, 2n=58 and 2n=60. Close to the 'border line' of the niche of each subspecies there is mating between individuals from different subspecies/different 2n chromosome number. Birth of fertile offspring implies that speciation of the subspecies has not been completed. [4]
In 2001, four new Nannospalax species (then classified within Spalax) endemic to geographical regions within Israel, Palestine and the Golan Heights were described based on chromosome divergence by a team of researchers led by Eviatar Nevo. These were: [5]
Although the ITIS and Mammal Species of the World still recognize these species, the American Society of Mammalogists and the IUCN Red List presently group these within N. ehrenbergi due to taxonomic uncertainty, such as lack of convincing genetic support for speciation, and the type locality of ehrenbergi itself likely falling within the range of one of these species. [6] [7] [8]
The Palestinian mole-rat weighs 100–200 grams (3.5–7.1 oz). It has light gray fur and four sharp teeth, two large teeth in the upper jaw and two smaller teeth in the lower jaw. It has a life span of up to 20 years and is notable for its adaptability to severe lack of oxygen. In Israel, the blind mole-rat is a major agricultural pest. It digs long tunnels up to 80 centimeters deep and stores onions and tubers in underground chambers. [9] The exceptional ecological adaptation strategies of the blind mole-rats can be seen in their different tongue morphologies, as evidenced by their tongue papillae. The tongue papillae differ between individuals in a species to adapt to different environmental regions with variant soil characteristics and food types. [10]
N. ehrenbergi is found in Egypt, Iraq, Turkey and the Levant (Israel, Syria, Palestine, Jordan and Lebanon). The natural habitat of the mole is Mediterranean-type shrubbish vegetation, and it is threatened by habitat loss.
According to Israeli researchers at Haifa University, the Middle East blind mole-rat is an important lab animal for researching cancer due to its apparent resistance to the disease. [9] In a 2013 study, data on N. ehrenbergi resistance to cancer was documented: [11]
-No spontaneous tumors have ever been noticed in blind mole rat, based on observing thousands of individuals along half a century. [11]
-Inducing cancer with chemical carcinogens that lead to 100% of the expected tumors in mice and rats after 2–6 months, respectively, indicate an extraordinary cancer resistance of Spalax: Only 2 out of 12 animals, and old ones (>10 years old; Spalax can live ~>20 years; 5 times longer than its evolutionary relative, the rat) developed the expected tumor with one of the carcinogens and only after 18 and 30 months. [11]
- Nannospalax cells (fibroblasts), and only Nannospalax cells, when grown in co-culture with cancer cells from different species, including a wide range of human cancer cells, kill the cancer cells. This is also true when "feeding" the cancer cells with the medium that Nannospalax cells grew in. Identification of the secreted substance/s by Nannospalax fibroblasts and the component on cancer cells' membrane they interact with, that lead to the cancer cells' death, can open a possibility for finding a general cure to cancer. [11]
Cancer resistance has also been noted in the two former species (N. judaei and N. golani) presently merged with this species. [12] N. galili had its genome sequenced in 2014. [13]
Studies on the growth of fibroblasts in vitro of N. judaei and N. golani showed that the process of necrosis replaces the role of the systematic apoptosis normally used in most organisms. Generally low-oxygen conditions, such as those common in blind mole rats’ burrows, usually cause cells to undergo apoptosis. One study showed that in adaptation to a higher tendency of cell death, blind mole rats evolved a mutation in the tumor suppressor protein p53, also used in humans, to prevent cells from undergoing apoptosis. [14] Human cancer patients have similar mutations, and blind mole rats were thought to be more susceptible to cancer because their cells cannot undergo apoptosis. However, after a specific amount of time (within 3 days according to one study), the cells in blind mole rats release interferon-beta (which the immune system normally uses to counter viruses) in response to over-proliferation of cells caused by the suppression of apoptosis. In this case, the interferon-beta triggers cells to undergo necrosis, and this mechanism also kills cancer cells in blind mole rats. Because of tumor suppression mechanisms such as this, blind mole rats and other spalacids are resistant to cancer. [15] [16] [17]
The involvement of interferon in the so-called concerted cell death of Spalax cells via necrosis was highly disputed. [15] Serious questions have been raised on the inconsistent methodology used that led to this speculation.
Observing the dirt displaced by burrowing mole rats can help archaeologists decide where to dig, since it often contains small artifacts like potsherds. [18] [19]
Necrosis is a form of cell injury which results in the premature death of cells in living tissue by autolysis. The term "necrosis" came about in the mid-19th century and is commonly attributed to German pathologist Rudolf Virchow, who is often regarded as one of the founders of modern pathology. Necrosis is caused by factors external to the cell or tissue, such as infection, or trauma which result in the unregulated digestion of cell components. In contrast, apoptosis is a naturally occurring programmed and targeted cause of cellular death. While apoptosis often provides beneficial effects to the organism, necrosis is almost always detrimental and can be fatal.
The naked mole-rat, also known as the sand puppy, is a burrowing rodent native to the Horn of Africa and parts of Kenya, notably in Somali regions. It is closely related to the blesmols and is the only species in the genus Heterocephalus.
The Valley of Elah or Ella Valley, called in Arabic: وادي السنط, Wadi es-Sunt, so-named from its Acacia albida trees, is a long, shallow valley in the Levant best known as the place described in the Hebrew Bible where the Israelites were encamped when David fought Goliath. It is home to several important archaeological sites, including those identified as the ancient towns of Azekah and Socho. Rising up from the valley on its extreme southeast end lies the hilltop ruin Adullam, and on its north lie the ruins of the ancient fortress city of Khirbet Qeiyafa, which is identified with the ancient town of Sha'araim.
The Spalacidae, or spalacids, are a family of rodents in the large and complex superfamily Muroidea. They are native to eastern Asia, the Horn of Africa, the Middle East, and southeastern Europe. It includes the blind mole-rats, bamboo rats, mole-rats, and zokors. This family represents the oldest split in the muroid superfamily, and comprises animals adapted to a subterranean way of life. These rodents were thought to have evolved adaptations to living underground independently until recent genetic studies demonstrated they form a monophyletic group. Members of the Spalacidae are often placed in the family Muridae along with all other members of the Muroidea.
Spalax is a genus of rodent in the family Spalacidae, subfamily Spalacinae. It is one of two extant genera in the subfamily Spalacinae, alongside Nannospalax.
The blind mole-rats, also known as the fossorial or subterranean mole rats, are a subfamily (Spalacinae) of rodents in the family Spalacidae, found in eastern Europe and western and central Asia. The hystricognath mole-rats of the family Bathyergidae are completely unrelated, but some other forms are also in the family Spalacidae. Zokors, root rats, and bamboo rats are spalacids also sometimes referred to as mole rats.
The blesmols, also known as mole-rats, or African mole-rats, are burrowing rodents of the family Bathyergidae. They represent a distinct evolution of a subterranean life among rodents much like the pocket gophers of North America, the tuco-tucos in South America, or the Spalacidae from Eurasia.
Thy-1 or CD90 is a 25–37 kDa heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte antigen. Thy-1 can be used as a marker for a variety of stem cells and for the axonal processes of mature neurons. Structural study of Thy-1 led to the foundation of the Immunoglobulin superfamily, of which it is the smallest member, and led to some of the initial biochemical description and characterization of a vertebrate GPI anchor and also the first demonstration of tissue specific differential glycosylation.
Nannospalax is a genus of rodent in the family Spalacidae, found in eastern Europe and western Asia. It is one of two genera in the blind mole-rats, alongside Spalax. Members of this genus are also known as small-bodied mole-rats. As with members of the genus Spalax, they are completely blind, with their eyes being entirely covered by skin.
The lesser blind mole-rat is a species of rodent in the family Spalacidae. It is found in Albania, Bosnia and Herzegovina, Bulgaria, Croatia, Greece, Hungary, North Macedonia, Moldova, Romania, Serbia, Montenegro, Turkey and Ukraine.
The Anatolian blind mole-rat or Nehring's blind mole-rat is a species of rodent in the family Spalacidae. It is found in Armenia, Georgia, and Turkey.
The giant blind mole-rat is a species of rodent in the family Spalacidae endemic to the North Caucasus region of Russia. It feeds on roots and tubers and lives underground in a burrow that it digs with its teeth.
The Bukovina blind mole-rat or (erroneously) the Balkan blind mole-rat is a species of rodent in the family Spalacidae found in Romania, Moldova, and Ukraine.
The greater blind mole-rat is a species of rodent in the family Spalacidae. It is found in Russia and Ukraine.
N. ehrenbergi may refer to:
Rochelle (Shelley) Buffenstein is an American comparative biologist currently working as Research Professor at the University of Illinois Chicago. Previously, she was a senior principal investigator at Calico Life Sciences, an Alphabet, Inc. funded research and development company investigating the biology that controls aging and lifespan where she used the extraordinarily long-lived cancer resistant naked mole-rat as an attractive counter-example to the inevitability of mammalian aging; for at ages greatly exceeding the expected maximum longevity for this mouse-sized rodent, they fail to exhibit meaningful changes in age-related risk of dying or physiological decline. As such these rodents likely provide the blueprint for how to stave off myriad adverse effects of aging and provide proof of concept that age-related health decline can be avoided in humans.
Comparative oncology integrates the study of oncology in non-human animals into more general studies of cancer biology and therapy. The field encompasses naturally seen cancers in veterinary patients and the extremely low rates of cancers seen in large mammals such as elephants and whales.
Mehely's blind mole-rat is an endangered species of rodent in the family Spalacidae. It is endemic to Romania.
The Oltenia blind mole-rat is a critically endangered, possibly extinct species of rodent in the family Spalacidae. It is endemic to Romania.
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