N-acetylneuraminate epimerase

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N-acetylneuraminate epimerase
Identifiers
EC number 5.1.3.24
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

N-acetylneuraminate epimerase (EC 5.1.3.24, sialic acid epimerase, N-acetylneuraminate mutarotase, sialic acid mutarotase, YjhT, NanM) is an enzyme with systematic name N-acetyl-alpha-neuraminate 2-epimerase. [1] This enzyme catalyses the following chemical reaction

Contents

N-acetyl-alpha-neuraminate N-acetyl-beta-neuraminate

Sialoglycoconjugates present in vertebrates are linked exclusively by alpha-linkages.

See also

Related Research Articles

Sialic acid is a generic term for a family of derivatives of neuraminic acid, an acidic sugar with a nine-carbon backbone. It is also the name for the most common member of this group, N-acetylneuraminic acid.

Sialyltransferases are enzymes that transfer sialic acid to nascent oligosaccharide. Each sialyltransferase is specific for a particular sugar substrate. Sialyltransferases add sialic acid to the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.

<i>N</i>-Acetylmannosamine monosaccharide

N-Acetylmannosamine is a hexosamine monosaccharide. It is a neutral, stable naturally occurring compound. N-Acetylmannosamine is also known as N-Acetyl-D-mannosamine monohydrate,, N-Acetyl-D-mannosamine which can be abbreviated to ManNAc or, less commonly, NAM). ManNAc is the first committed biological precursor of N-acetylneuraminic acid. Sialic acids are the negatively charged, terminal monosaccharides of carbohydrate chains that are attached to glycoproteins and glycolipids (glycans).

In enzymology, an aldose 1-epimerase is an enzyme that catalyzes the chemical reaction

N-acetylneuraminate lyase class of enzymes

In enzymology, a N-acetylneuraminate lyase is an enzyme that catalyzes the chemical reaction

N-acetylneuraminate synthase class of enzymes

In enzymology, a N-acetylneuraminate synthase (EC 2.5.1.56) is an enzyme that catalyzes the chemical reaction

In enzymology, a N-acylneuraminate-9-phosphate synthase (EC 2.5.1.57) is an enzyme that catalyzes the chemical reaction

In enzymology, a beta-galactoside alpha-2,3-sialyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a beta-galactoside alpha-2,6-sialyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a lactosylceramide alpha-2,3-sialyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a lactosylceramide alpha-2,6-N-sialyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a monosialoganglioside sialyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a N-acetyllactosaminide alpha-2,3-sialyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a neolactotetraosylceramide alpha-2,3-sialyltransferase is an enzyme that catalyzes the chemical reaction

GNE (gene) protein-coding gene in the species Homo sapiens

Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase is an enzyme that in humans is encoded by the GNE gene.

ST6GALNAC4 protein-coding gene in the species Homo sapiens

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4, also known as sialyltransferase 3C (SIAT3-C) or sialyltransferase 7D (SIAT7-D) is a sialyltransferase enzyme that in humans is encoded by the ST6GALNAC4 gene.

Kelch motif InterPro Domain

The Kelch motif is a region of protein sequence found widely in proteins from bacteria and eukaryotes. This sequence motif is composed of about 50 amino acid residues which form a structure of a four stranded beta-sheet "blade". This sequence motif is found in between five and eight tandem copies per protein which fold together to form a larger circular solenoid structure called a beta-propeller domain.

(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase is an enzyme with systematic name UDP-N-acetyl-D-galactosamine:1-O-(O- - -O-beta-D-galactopyranosyl- -beta-D-glucopyranosyl)-ceramide 4-beta-N-acetyl-D-galactosaminyltransferase. This enzyme catalyses the following chemical reaction

Alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase is an enzyme with systematic name CMP-N-acetylneuraminate:N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)- N-acetyl-D-galactosaminide galactosamine-6-alpha-N-acetylneuraminyltransferase. This enzyme catalyses the following chemical reaction

UDP-N-acetylglucosamine 2-epimerase (hydrolysing) (EC 3.2.1.183, UDP-N-acetylglucosamine 2-epimerase, GNE (gene), siaA (gene), neuC (gene)) is an enzyme with systematic name UDP-N-acetyl-alpha-D-glucosamine hydrolase (2-epimerising). This enzyme catalyses the following chemical reaction

References

  1. Severi E, Müller A, Potts JR, Leech A, Williamson D, Wilson KS, Thomas GH (February 2008). "Sialic acid mutarotation is catalyzed by the Escherichia coli beta-propeller protein YjhT". The Journal of Biological Chemistry. 283 (8): 4841–9. doi: 10.1074/jbc.M707822200 . PMID   18063573.