N-acylglucosamine-6-phosphate 2-epimerase

Last updated
N-acylglucosamine-6-phosphate 2-epimerase
Identifiers
EC no. 5.1.3.9
CAS no. 37318-35-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

In enzymology, a N-acylglucosamine-6-phosphate 2-epimerase (EC 5.1.3.9) is an enzyme that catalyzes the chemical reaction

N-acyl-D-glucosamine 6-phosphate N-acyl-D-mannosamine 6-phosphate

Hence, this enzyme has one substrate, N-acyl-D-glucosamine 6-phosphate, and one product, N-acyl-D-mannosamine 6-phosphate.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is N-acyl-D-glucosamine-6-phosphate 2-epimerase. Other names in common use include acylglucosamine-6-phosphate 2-epimerase, and acylglucosamine phosphate 2-epimerase. This enzyme participates in aminosugars metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1Y0E and 1YXY.

Related Research Articles

<i>N</i>-Acetylmannosamine Chemical compound

N-Acetylmannosamine is a hexosamine monosaccharide. It is a neutral, stable naturally occurring compound. N-Acetylmannosamine is also known as N-Acetyl-D-mannosamine monohydrate,, N-Acetyl-D-mannosamine which can be abbreviated to ManNAc or, less commonly, NAM). ManNAc is the first committed biological precursor of N-acetylneuraminic acid. Sialic acids are the negatively charged, terminal monosaccharides of carbohydrate chains that are attached to glycoproteins and glycolipids (glycans).

<span class="mw-page-title-main">Phosphopentose epimerase</span>

Phosphopentose epimerase encoded by the RPE gene is a metalloprotein that catalyzes the interconversion between D-ribulose 5-phosphate and D-xylulose 5-phosphate.

In enzymology, a N-acylmannosamine 1-dehydrogenase (EC 1.1.1.233) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">N-acylglucosamine 2-epimerase</span>

In enzymology, a N-acylglucosamine 2-epimerase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Phosphoacetylglucosamine mutase</span>

In enzymology, a phosphoacetylglucosamine mutase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">UDP-N-acetylglucosamine 2-epimerase</span> Class of enzymes

In enzymology, an UDP-N-acetylglucosamine 2-epimerase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">UDP-N-acetylglucosamine 4-epimerase</span> Class of enzymes

In enzymology, an UDP-N-acetylglucosamine 4-epimerase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Glucosamine-6-phosphate deaminase</span>

In enzymology, a glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Glucosamine-phosphate N-acetyltransferase</span>

In enzymology, glucosamine-phosphate N-acetyltransferase (GNA) is an enzyme that catalyzes the transfer of an acetyl group from acetyl-CoA to the primary amine in glucosamide-6-phosphate, generating a free CoA and N-acetyl-D-glucosamine-6-phosphate.

<span class="mw-page-title-main">N-acetylneuraminate synthase</span>

In enzymology, a N-acetylneuraminate synthase (EC 2.5.1.56) is an enzyme that catalyzes the chemical reaction

In enzymology, a N-acylneuraminate-9-phosphate synthase (EC 2.5.1.57) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Glutamine—fructose-6-phosphate transaminase (isomerizing)</span>

In enzymology, a glutamine-fructose-6-phosphate transaminase (isomerizing) is an enzyme that catalyzes the chemical reaction

In enzymology, a 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">N-acylmannosamine kinase</span>

In enzymology, a N-acylmannosamine kinase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">RENBP</span> Mammalian protein found in Homo sapiens

N-acylglucosamine 2-epimerase is an enzyme that in humans is encoded by the RENBP gene.

UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase is an enzyme with systematic name (3R)-3-hydroxymyristoyl-(acyl-carrier protein):UDP-3-O-( -3-hydroxymyristoyl)-alpha-D-glucosamine N-acetyltransferase. This enzyme catalyses the following chemical reaction

UDP-N-acetylglucosamine 2-epimerase (hydrolysing) (EC 3.2.1.183, UDP-N-acetylglucosamine 2-epimerase, GNE (gene), siaA (gene), neuC (gene)) is an enzyme with systematic name UDP-N-acetyl-alpha-D-glucosamine hydrolase (2-epimerising). This enzyme catalyses the following chemical reaction

<span class="mw-page-title-main">Epimerox</span> Chemical compound

Epimerox is an experimental broad-spectrum antibiotic compound being developed by scientists at the Rockefeller University and Astex Pharmaceuticals. It is a small molecule inhibitor compound that blocks the activity of the enzyme UDP-N-acetylglucosamine 2-epimerase, an epimerase enzyme that is called 2-epimerase for short.

2-Epimerase can refer one of to several enzymes:

References