Ned D. Heindel | |
---|---|
Born | [1] | September 4, 1937
Died | Easton, PA |
Nationality | American |
Board member of | President of the American Chemical Society |
Awards | ACS fellow |
Academic background | |
Alma mater | Lebanon Valley College, University of Delaware |
Academic work | |
Discipline | Chemistry |
Sub-discipline | Organic chemistry,medicinal chemistry |
Institutions | Lehigh University |
Ned D. Heindel (September 4,1937) was an American chemist. He was the Howard S. Bunn Distinguished Professor Emeritus of Chemistry at Lehigh University,where he continued to do research. [2] Heindel also worked as a medical research consultant. [3] [1] [4] Heindel's research focused on diagnostic and therapeutic drug development. He served as president of the American Chemical Society in 1994, [5] and has twice chaired the ACS Division for the History of Chemistry. [6] He died on June 27,2023. [7]
Ned Duane Heindel was born on September 4,1937,in Red Lion,York County,Pennsylvania,to Mr. and Mrs. Penrose H. Heindel. [6] [8] He earned a B.S. in chemistry from Lebanon Valley College (1959),and a master's degree (1961) and Ph.D. (1963) from the University of Delaware, [9] where he worked with William A. Mosher. [2] He did postdoctoral work at Princeton University in 1964 [10] with Edward C. Taylor. [2]
After teaching briefly at Ohio University and Marshall University Heindel joined the faculty at Lehigh University in 1966. He became a full professor by 1973, [2] and was named the Howard S. Bunn Distinguished Professor of Organic Chemistry in 1976. [1] [11] [8]
Heindel also served as a visiting professor of radiation oncology at Hahnemann University Hospital from 1971 to 2006,and as director of the Center for Health Sciences at Lehigh University from 1980 to 1987. He helped to establish the Lehigh-Hahnemann Cooperative Medical Education Program from 1992 to 2017 and was involved in Lehigh's distance education program. [2]
Heindel became professor emeritus in 2018. He continues to do research (e.g. healing burn wounds [12] ) and works as a medical research consultant. [2]
Heindel's research focuses on diagnostic and therapeutic drug development,including the areas of cancer research,nuclear medicine,diagnostic radioactive pharmaceuticals, [1] [13] [14] chemotherapeutics and tumor-associated monoclonal antibodies. [15] He has applied for at least 20 patents,with 14 issued. [2] [10] [16] He has published more than 260 papers. [2] [17] A number of candidate pharmaceuticals from his lab have reached advanced animal trials. [18] [19]
Heindel has shown that psoralens and coumarins can be useful as photoactivated inhibitors of epidermal growth factor. [20] [21] [22] [23] Photosensitizers are used to treat epidermal proliferation,psoriasis and vitiligo. Heindel's lab has identified a new structural family of organic molecules which perform as light-activated anti-cancer compounds. After activation by ultraviolet light,lipophilic dipyranone (NDH2476) was found to inhibit abnormal Keratinocyte growth with an IC50 of 9 nanomolar concentration. NDH2476 acts through initial intercalation into DNA and when irradiated,“nicks”the polynucleotide and prevents subsequent unwinding. Gem di-methylation,double bond hydrogenation,or non-linear,angular geometry to the dipyranone greatly reduced or even eliminated the photo-cytotoxicity. [24]
Heindel is one of the principal investigators in Project CounterACT-Rutgers,studying antidotes to sulfur mustard gas poisoning. [25] [10] Heindel's lab has developed an indomethacin prodrug,NDH4338,designed for use as a wound-healing accelerant for vesicant-triggered skin lesions. The drug is a trifunctional pharmaceutical composed of covalently linked inhibitors of COX-2,acetylcholinesterase,and induced nitric oxide synthase which can be released in vivo from the parent molecule. It has been tested on rodents pre-exposed to chloroethyl ethyl sulfide,nitrogen mustard,and sulfur mustard and has shown a marked acceleration of wound healing. While NDH4338 has several mechanisms of action,a principle one is suppression of mast cell degranulation in skin. [19] [26]
Hydroxamate compounds developed by Heindel's lab have been found to enhance corneal wound healing after mustard exposure. Compounds studied include olvanil OH (NDH4409) and retro olvanil 8 (NDH4417). Hydroxamates reduced the activity of ADAM17 and matrix metalloproteinases (MMPs),and attenuated expression of EMMPRIN,a tumor cell surface inducer of MMPs. This resulted in less epithelial sloughing,improved protection of the basement membrane zone,and better epithelial-stromal integrity after injury. [27]
Heindel serves on the board of directors of the Pennsylvania Drug Discovery Institute, [28] and the Scientific Advisory Board of Azevan Pharmaceuticals,Inc. [4]
Heindel has held a number of positions in the American Chemical Society (ACS),since first becoming a board member in 1985. [5] In 1994,Heindel served as President of the ACS. [29] [30] In 2009 Heindel was named an ACS Fellow. [31]
Heindel has served on the board of directors of the National Foundation for History of Chemistry, [32] and has twice been chairperson of the ACS Division of the History of Chemistry. [6] Heindel has been credited with chairing a task force formed by the ACS in 1979 to consider the creation of a national center for the history of chemistry, [33] but he himself credits John H. Wotiz with that chairmanship. [34] In December 1981 the ACS approved the establishment of the Center for the History of Chemistry in Philadelphia. [33] [35] He was a contributor to a NOVA program about Percy Julian,“Forgotten Genius”,which aired in 2007. [2]
Heindel has written both papers and books relating history and chemistry. Among his publications he has examined "The Professionalization of American Chemistry:How the German Ph.D. Model Crossed the Atlantic", [36] and the careers of early photochemists such as Giacomo Ciamician. [37]
Another area of interest is the medicinal chemistry and folk-healing techniques of the Pennsylvania Dutch. The Nineteenth Century Horse Doctor:A Pennsylvania Dutchman's Practical Guide to Treating Horses recognized the essential role of the horse in pre-industrial North American farming. Heindel and Robert D. Rapp translate and examine recipes in 19th century books of veterinary practice,or "Pferdartz",from the Moravian and the Pennsylvania Dutch traditions. Folk medicine cures ranged from herbs,minerals,poultices,and bleeding to incantations. [38] [39]
In Hexenkopf,History,Healing and Hexerei,he examines traditions of both white and black magic in the Wilhelm and Saylor families of Northampton County,Pennsylvania. Healers such as Johann Peter Seilor [40] and Emanuel Wilhelm used tonics,personalized prescriptions and manipulations to treat sickness and fight off evil in the tradition of white magic or "Braucherei". Modern pharmaceutical science has examined the use of some of their treatments such as poke root and mayapple root. [41] Traditions of black magic have focused on Hexenkopf Rock. [42] [43] [44]
Heindel and his wife Linda (Heefner) Heindel are active in historical groups in the Lehigh Valley [45] and frequently contribute to Pennsylvania Folklife Magazine. [46] Heindel has lectured on social relationships between Europeans,Lenni Lenape,and Shawnee in the Durham area in the 1700s. He is interested in the work of the Buckwampum Historical and Literary Society, [47] a group that met from 1888 to 1903. Most were amateurs but archaeologist Henry Mercer was also a member. The group conducted several digs in Bucks County,Pennsylvania,and Northampton County,Pennsylvania. [48]
Over a 50 year period,Ned and Linda Heindel have purchased and preserved 128 acres of "forest,bogs and meadows" around the stone farmhouse in which they live,in Williams Township,Northampton County,Pennsylvania. The hilly area includes stands of ash,poplar and oak trees,wild azalea,freshwater springs and Hexenkopf Rock,a ridge of exposed Precambrian stone. [49] Linda Heindel serves as the secretary of the Land Preservation Board of Williams Township,Northampton County,PA. [50]
As of August 2014,a consortium of energy companies announced plans to build the PennEast Pipeline to carry natural gas from the Marcellus Shale in Pennsylvania into New Jersey. Ned and Linda Heindel are among residents who would be affected. [49]
Beginning on February 6,2018,the PennEast Pipeline Co. has filed eminent domain notices in federal court to take possession of rights of way on the lands of those who have not agreed to the pipeline. [51] Those who received eminent domain notices include at least 129 New Jersey landowners [52] and 50 Pennsylvania landowners, [53] among them the Heindels. [54] The Heindels are active opponents of the proposed pipeline and the attempted seizure of their land under eminent domain. [55] [49] [54]
Stuart Schreiber is an American chemist who is the Morris Loeb Research Professor at Harvard University,a co-founder of the Broad Institute,Howard Hughes Medical Institute Investigator,Emeritus,and a member of the National Academy of Sciences and National Academy of Medicine. He currently leads Arena BioWorks.
Tobin Jay Marks is an inorganic chemistry Professor,the Vladimir N. Ipatieff Professor of Catalytic Chemistry,Professor of Material Science and Engineering,Professor of Chemical and Biological Engineering,and Professor of Applied Physics at Northwestern University in Evanston,Illinois. Among the themes of his research are synthetic organo-f-element and early-transition metal organometallic chemistry,polymer chemistry,materials chemistry,homogeneous and heterogeneous catalysis,molecule-based photonic materials,superconductivity,metal-organic chemical vapor deposition,and biological aspects of transition metal chemistry.
Carolyn Ruth Bertozzi is an American chemist and Nobel laureate,known for her wide-ranging work spanning both chemistry and biology. She coined the term "bioorthogonal chemistry" for chemical reactions compatible with living systems. Her recent efforts include synthesis of chemical tools to study cell surface sugars called glycans and how they affect diseases such as cancer,inflammation,and viral infections like COVID-19. At Stanford University,she holds the Anne T. and Robert M. Bass Professorship in the School of Humanities and Sciences. Bertozzi is also an Investigator at the Howard Hughes Medical Institute (HHMI) and is the former director of the Molecular Foundry,a nanoscience research center at Lawrence Berkeley National Laboratory.
In genetics,crosslinking of DNA occurs when various exogenous or endogenous agents react with two nucleotides of DNA,forming a covalent linkage between them. This crosslink can occur within the same strand (intrastrand) or between opposite strands of double-stranded DNA (interstrand). These adducts interfere with cellular metabolism,such as DNA replication and transcription,triggering cell death. These crosslinks can,however,be repaired through excision or recombination pathways.
The Science History Institute is an institution that preserves and promotes understanding of the history of science. Located in Philadelphia,Pennsylvania,it includes a library,museum,archive,research center and conference center.
JoAnne Stubbe is an American chemist best known for her work on ribonucleotide reductases,for which she was awarded the National Medal of Science in 2009. In 2017,she retired as a Professor of Chemistry and Biology at the Massachusetts Institute of Technology.
Cynthia "Cyndie" Anne Maryanoff is an American organic and materials chemist. Among other awards,she received the 2015 Perkin Medal for outstanding work in applied chemistry in the U.S.A.
Derek Lowe is a medicinal chemist working on preclinical drug discovery in the pharmaceutical industry. Lowe has published a blog about this field,"In the Pipeline",since 2002 and is a columnist for the Royal Society of Chemistry's Chemistry World.
Elsa Reichmanis is an American chemist,who was the 2003 president of the American Chemical Society. She was elected a member of the National Academy of Engineering in 1995 for the discovery,development,and engineering leadership of new families of lithographic materials and processes that enable VLSI manufacturing. She was also inducted into the National Academy of Inventors in 2020. She is currently the Anderson Endowed Chair in Chemical and Biomolecular Engineering at Lehigh University. She previously served on the faculty at The Georgia Institute of Technology. Reichmanis is noted for her research into microlithography,and is credited for contributing to the "development of a fundamental molecular level understanding of how chemical structure affects materials function leading to new families of lithographic materials and processes that may enable advanced VLSI manufacturing".
Hai-Lung Dai is a Taiwanese-born American physical chemist and university administrator. He currently is the Laura H. Carnell Professor of Chemistry and Vice President for International Affairs at Temple University in Philadelphia,Pennsylvania,in the United States.
Peter Wipf is a distinguished university professor of chemistry at the University of Pittsburgh. His research interests focus on the total synthesis of natural products,the discovery of new transformations of strained molecules,and the development of new pharmaceuticals. He is a Fellow of the Royal Society of Chemistry (RSC),the American Association for the Advancement of Science (AAAS),and the American Chemical Society (ACS).
Ann E. Weber is the senior vice president for drug discovery at Kallyope Inc. in New York City. She previously worked with Merck Research Laboratories (MRL),joining the company in 1987 and retiring from the position of vice president for lead optimization chemistry in 2015. She has helped develop more than 40 drug candidates including FDA-approved treatments for Type 2 diabetes. She has received a number of awards,including the Perkin Medal (2017) and has been inducted into the ACS Division of Medicinal Chemistry’s MEDI Hall of Fame.
Nancy A. Thornberry is the founding CEO and current chair,R&D at Kallyope Inc. in New York City. She previously worked with Merck Research Laboratories (MRL),joining the company in 1979 as a biochemist and retiring from the position of senior vice president and franchise head,diabetes and endocrinology in 2013.
Kenneth M. Merz Jr. is an American biochemist and molecular biologist currently the Joseph Zichis Chair and a distinguished university professor at Michigan State University and editor-in-chief of American Chemical Society's Journal of Chemical Information and Modeling. A highly cited expert in his field,his research interests are in computational chemistry and biology and computer-aided drug design (CADD). His group has been involved in developing the widely using AMBER suite of programs for simulating chemical and biological systems and the QUICK program for quantum chemical calculations.
Kelly Chibale PhD,MASSAf,FAAS,Fellow of UCT,FRSSAf,FRSC is professor of organic chemistry at the University of Cape Town,and the founder and director of H3D research center and H3D Foundation NPC. In 2018 he was recognised as one of Fortune magazine's top 50 World's Greatest Leaders. His research focuses on drug discovery and the development of tools and models to contribute to improving treatment outcomes in people of African descent or heritage.
Alexandros Makriyannis is an American biochemist and professor of chemistry and chemical biology in the department of medicinal chemistry at Northeastern University in Boston,Massachusetts,where he directs the Center for Drug Discovery and holds the George Behrakis Chair of Pharmaceutical Biotechnology. His research has focused on the biochemical basis of the endocannabinoid system and on the development of synthetic cannabinoids.
Kay Michille Brummond is an American synthetic chemist who is Professor of Chemistry and Associate Dean of Faculty at the University of Pittsburgh. Her interests consider cycloaddition reactions that can realise molecules and natural products for organic photovoltaics and targeted covalent inhibitors. She was elected a Fellow of the American Chemical Society (ACS) in 2010,a Fellow of the AAAS in 2021,and awarded the ACS National Award for Encouraging Women into Careers in the Chemical Sciences in 2021.
Julia Laskin is the William F. and Patty J. Miller Professor of Analytical Chemistry at Purdue University. Her research is focused on the fundamental understanding of ion-surface collisions,understanding of phenomena underlying chemical analysis of large molecules in complex heterogeneous environments,and the development of new instrumentation and methods in preparative and imaging mass spectrometry.
Christine D. Keating is an American scientist who is the Shapiro Professor of Chemistry at Pennsylvania State University. Her research involves colloid and interface chemistry for biology and materials science.
{{cite book}}
: CS1 maint: multiple names: authors list (link)U.S. Pat. No. 5,216,176 of Heindel discloses a large number of psoralens and coumarins that have some effectiveness as photoactivated inhibitors of epidermal growth factor. Halogens and amines are included among the vast functionalities that could be included in the psoralen/coumarin backbone.