U.S. Route 22 (US 22) is a major east–west route and one of the original United States Numbered Highways, founded in 1926. It runs from Cincinnati, Ohio, at US 27, US 42, US 127, and US 52 to Newark, New Jersey, at US 1/9 at the Newark Airport Interchange.
Interstate 71 (I-71) is a north–south Interstate Highway in the midwestern and southeastern regions of the United States. Its southern terminus is at an interchange with I-64 and I-65 in Louisville, Kentucky, and its northern terminus at an interchange with I-90 in Cleveland, Ohio. I-71 runs concurrently with I-75 from a point about 20 miles (32 km) south of Cincinnati, Ohio, into Downtown Cincinnati. While most odd numbered Interstates run north–south, I-71 takes more of a northeast–southwest course, with some east–west sections, and is mainly a regional route serving Kentucky and Ohio. It links I-80 and I-90 to I-70 and ultimately links to I-40. Major metropolitan areas served by I-71 include Louisville, Cincinnati, Columbus, and Cleveland.
Interstate 271 (I-271) is an auxiliary Interstate Highway in the suburbs of Cleveland and Akron in the US state of Ohio. The highway is officially designated the Outerbelt East Freeway but is rarely referred to by that name by locals, instead simply referring to it as "271".
U.S. Route 42 is an east–west United States highway that runs southwest–northeast for 350 miles (560 km) from Louisville, Kentucky to Cleveland, Ohio. The route has several names including Pearl Road from Cleveland to Medina in Northeast Ohio, Reading Road in Cincinnati, Cincinnati and Lebanon Pike in southwestern Ohio and Brownsboro Road in Louisville. Traveling northeast, the highway ends in downtown Cleveland and traveling southwest ends in Louisville.
U.S. Route 322 is a 494-mile-long (795.0 km), east–west United States Highway, traversing Ohio, Pennsylvania, and New Jersey. The road is a spur of US 22 and one of the original highways from 1926. A portion of it at one time was concurrent with the Lakes-to-Sea Highway.
Interstate 475 (I-475) is an auxiliary Interstate Highway in Ohio that is a 20.37-mile (32.78 km) western bypass of Toledo. The southern terminus is I-75 exit 192 near Perrysburg. From the southern terminus to exit 14, I-475 is cosigned with US Route 23 (US 23) and is signed the north–south section of I-475. From exit 14 to the eastern (northernmost) terminus at I-75 exit 204 in central Toledo, it is signed the east–west section of I-475.
State Route 32 (SR 32), also known as the James A. Rhodes Appalachian Highway, is a major east–west highway across the southern portion of the U.S. state of Ohio. It is the eighth longest state route in Ohio, spanning southern Ohio from Cincinnati to Belpre, across the Ohio River from Parkersburg, West Virginia. Except in Belpre, leading up to the bridge into West Virginia, the entire route outside Cincinnati's beltway is a high-speed four-lane divided highway, forming the Ohio portion of Corridor D of the Appalachian Development Highway System.
Interstate 76 (I-76) is an east–west Interstate Highway in the Eastern United States. The highway runs approximately 435.66 miles (701.13 km) from an interchange with I-71 west of Akron, Ohio, east to I-295 in Bellmawr, New Jersey. This route is not contiguous with I-76 in Colorado and Nebraska.
Interstate 275 (I-275) is an 83.71-mile-long (134.72 km) highway in Ohio, Indiana, and Kentucky that forms a complete beltway around the Cincinnati metropolitan area and includes a part in a state (Indiana) not entered by the parent route. It had been the only auxiliary Interstate that enters three states, but that changed in July 2018 when I-295 in Delaware and New Jersey was extended into Pennsylvania. It is the longest beltway with an Interstate highway designation in the United States, enclosing an area of over 250,000 acres (100,000 ha). It is also the third longest beltway overall in the United States; only the Sam Houston Tollway and the Grand Parkway, both encircling Greater Houston, are longer. For a short distance in northwest Hamilton County, it overlaps with I-74 and US Route 52 (US 52).
State Route 3 is a major north–south highway in Ohio which leads from Cincinnati to Cleveland by way of Columbus. It is the second longest state route in Ohio. For this reason, the road is also known as the 3-C Highway, a designation which antedates the Ohio state highway system. It is the only state route to enter all three of Ohio's largest cities, though it has largely been bypassed by Interstate 71 (I-71).
State Route 43 is a mainly north–south state highway that runs through the northeastern quadrant of the U.S. state of Ohio. Its southern terminus is at a signalized intersection with State Route 7 along the Ohio River in Steubenville, and its western terminus is approximately 123 miles (198 km) to the north at Public Square in Cleveland. It is one of ten routes to enter Public Square.
State Route 10 is a state highway located in and around Cleveland, Ohio. The route's western terminus is in Eaton Township in Lorain County, and the eastern terminus is in Cleveland's University Circle neighborhood.
Interstate 80 (I-80) in the US state of Ohio runs across the northern part of the state. Most of the route is part of the Ohio Turnpike; only an 18.78-mile (30.22 km) stretch is not part of the toll road. That stretch of road is the feeder route to the Keystone Shortway, a shortcut through northern Pennsylvania that provides access to New York City.
Interstate 77 (I-77) in Ohio is an Interstate Highway that runs for 163.03 miles (262.37 km) through the state. The highway crosses into Ohio on the Marietta–Williamstown Interstate Bridge over the Ohio River near Marietta. The northern terminus is in Cleveland at the junction with I-90. From the West Virginia state line to Cleveland, I-77 serves the cities of Marietta, Cambridge, New Philadelphia, Canton, Akron, and the Cleveland suburban city of Brecksville.
Interstate 90 (I-90) runs east–west across the northern tier of the US state of Ohio. Much of it is along the Ohio Turnpike, but sections outside the turnpike pass through Cleveland and northeast into Pennsylvania.
U.S. Route 50 runs east–west across the southern part of the state of Ohio, passing through Cincinnati, Chillicothe, and Athens. It is mainly a two-lane road except for the easternmost and westernmost parts. Near Athens it runs concurrently with State Route 32 (SR 32), a four-lane divided highway known as Corridor D, and from Coolville to the Ohio–West Virginia border it also overlaps SR 7 before crossing into Parkersburg, West Virginia.
Interstate 75 (I-75) runs from Cincinnati to Toledo by way of Dayton in the US state of Ohio. The highway enters the state running concurrently with I-71 from Kentucky on the Brent Spence Bridge over the Ohio River and into the Bluegrass region. I-75 continues along the Mill Creek Expressway northward to the Butler County line just north of I-275. From there, the freeway runs into the Miami Valley and then passes through the Great Black Swamp before crossing into Michigan.
U.S. Route 20 (US 20) is a United States Numbered Highway that runs from Newport, Oregon, to Boston, Massachusetts. Within the state of Ohio, the route runs from the Indiana border near Edon to the Pennsylvania border at Conneaut. The route passes through rural areas west of Toledo and passes through Public Square in Cleveland. It is one of nine other routes to enter Downtown Cleveland at Public Square, and it serves some of Cleveland's northeastern suburbs.
U.S. Route 23 (US 23) is a United States Numbered Highway that runs from Jacksonville, Florida, to Mackinaw City, Michigan. In the state of Ohio, it is a major north–south state highway that runs from the Kentucky border at Portsmouth to the Michigan border at Sylvania.
US Highway 25 (US 25) was a part of the United States Numbered Highway System in the state of Ohio that ran from its present terminus near Covington, Kentucky, to its Michigan continuation. By the time it was decommissioned in 1973, all but the section north of Cygnet ran concurrently with Interstate 75 (I-75).
