State Route 281 is an east–west state highway in the northwestern portion of the U.S. state of Ohio. Its western terminus is at U.S. Route 24 approximately four miles (6.4 km) northeast of downtown Defiance, and its eastern terminus is at US 6 nearly one mile (1.6 km) north of Bradner. The majority of the route is known as the Defiance Pike.
State Route 269 is a north–south state highway in the north central portion of the U.S. state of Ohio. Its southern terminus is at SR 4 on the Huron–Seneca county line nearly seven miles (11 km) south of Bellevue, and its northern terminus is at the entrance to East Harbor State Park near Marblehead.
State Route 306 is a north–south state highway in northeastern Ohio, running from its southern terminus at SR 43 in Aurora to its northern terminus at SR 283 in Mentor. Most of the road from Aurora north to Kirtland is part of the former Chillicothe Turnpike and is known as Chillicothe Road. The Kirtland Temple, the first temple built by the Latter Day Saint movement (Mormons), is located on SR 306 in central Kirtland.
State Route 38 is a south–north state highway in the state of Ohio. Its southern terminus is near Bloomingburg and Washington Court House at the U.S. Route 62 / SR 3 concurrency and its northern terminus is in Marysville at the intersection of 5th Street and Main Street where the road continues north as SR 31.
State Route 79 is a north–south highway that traverses Central Ohio, extending from Buckeye Lake at SR 37 to Nellie at US 36. SR 79 serves Newark, providing direct-access from Downtown Newark to I-70.
State Route 304 is an east–west state highway in the northeastern portion of Ohio. The western terminus of SR 304 is at a signalized intersection with US 422 in Girard. Its eastern terminus is at the Pennsylvania State Line nearly 3 miles (4.8 km) east of Hubbard, where the highway continues east as Pennsylvania Route 318.
State Route 355 was a short 1.37-mile-long (2.20 km) state highway in southwestern Ohio. The route served the former Fort St. Clair State Memorial in Eaton, Preble County. The route began at SR 122 in western Eaton, traveled south along Camden Road for about 0.3 miles (0.48 km) before turning into the memorial, looping through the entire site, and ending at itself just south of the route's start at SR 122. The route was removed from the state highway system shortly after the park's jurisdiction was transferred from the state to the City of Eaton.
State Route 326 was the final designation for a short state highway near Holland, Ohio. At the time the route was removed from the state highway system in 1934, the road had been a state highway since the system's creation but with different designations throughout its history.
State Route 721 (SR 721) is a north–south state highway located in the western portion of the U.S. state of Ohio. The southern terminus of SR 721 is at a T-intersection with SR 49 approximately 2.75 miles (4.43 km) south of the village of Potsdam. Its northern terminus is also at a T-intersection, this time with SR 185 on the Darke–Miami County Line nearly 1.50 miles (2.41 km) north of Bradford.
State Route 722 is an east–west state highway in the western portion of the U.S. state of Ohio. The western terminus of SR 722 is at a T-intersection with SR 121 approximately 3.25 miles (5.23 km) southwest of New Madison. Its eastern terminus is at SR 49 nearly 3.75 miles (6.04 km) east of the village of Gordon.
State Route 571 is an east–west state highway in west-central Ohio, part of a statewide road transportation system. It indirectly connects the cities of Union City and Greenville with Springfield via a final 10.7 miles (17.2 km) on U.S. Route 40.
State Route 185 (SR 185) is a 21.70-mile (34.92 km) long east–west state highway in the western part of the U.S. state of Ohio. The western terminus of SR 185 is at U.S. Route 127 (US 127) approximately 3.75 miles (6.04 km) south of North Star. Its eastern terminus is in Piqua. Until 2011, this was at its junction with US 36 and SR 66 in the city's downtown business district, at the intersection of Ash Street and Spring Street. In 2011, SR 185 was re-routed to travel south along Sunset Drive in the western part of Piqua to a new eastern terminus where Sunset Drive meets US 36, which is known as Covington Avenue at that location.
State Route 751 is an east–west state highway located in the east-central portion of Ohio. The highway runs between its western terminus at SR 93 in West Lafayette and its eastern terminus at a diamond interchange with I-77 on the outskirts of the village of Stone Creek.
State Route 362 is a 4.56-mile (7.34 km) north–south state highway in the western part of the U.S. state of Ohio. It serves to connect Lake Loramie State Park with SR 66. Its southern terminus is in Fort Loramie at the intersection of North Main Street (SR 66) and Elm Street. near the northern edge of Fort Loramie. SR 362 then runs about 1.1 miles (1.8 km) east, then turns north at its intersection with Fort Loramie–Swanders Road. SR 362 then runs northerly along the western edge of Lake Loramie and Lake Loramie State Park before turning northwesterly then westerly and enters Minster and reaches its northern terminus at the intersection of South Main Street (SR 66) and First Street.
State Route 374 is north–south state highway in Hocking County, Ohio, located in the southern portion of the state. Its southern terminus is over 4 miles (6.4 km) east of the unincorporated village of South Bloomingville at State Route 56, and its northern terminus is near the unincorporated village of Rockbridge at US 33, west of Logan. The road serves Hocking State Forest as well as Hocking Hills State Park, and the entire highway is part of the designated Hocking Hills Scenic Byway.
US 35 in Trotwood 
M-49 near Cooney 
