|Maintained by KYTC and ODOT|
|Length||343.78 mi (553.26 km)|
|Restrictions||No hazmats or explosives allowed in the Lytle Tunnel or on the Brent Spence Bridge|
|South end||I-64 / I-65 in Louisville, KY|
|North end||I-90 / I-490 in Cleveland, OH|
|Counties||KY: Jefferson, Oldham, Henry, Trimble, Carroll, Gallatin, Boone, Kenton |
OH: Hamilton, Warren, Clinton, Greene, Fayette, Madison, Pickaway, Franklin, Delaware, Morrow, Richland, Ashland, Wayne, Medina, Cuyahoga
Interstate 71 (I-71) is a north–south Interstate Highway in the Great Lakes/Midwestern and Southeastern region of the United States. Its southern terminus is at an interchange with I-64 and I-65 (the Kennedy Interchange) in Louisville, Kentucky, and its northern terminus at an interchange with I-90 in Cleveland, Ohio. I-71 runs concurrently with I-75 from a point about 20 miles (32 km) south of Cincinnati, Ohio, into Downtown Cincinnati. While most odd numbered Interstates are north–south, I-71 however is designated more of a northeast–southwest highway, with some east–west sections, and is mainly a regional route, serving Kentucky and Ohio. It links I-80 and I-90 to I-70, and ultimately (via I-65) links to I-40. Major metropolitan areas served by I-71 include Louisville, Cincinnati, Columbus, and Cleveland.
Approximately three quarters of the route lie east of I-75, leaving I-71 out of place in the Interstate grid.
This section needs expansion. You can help by adding to it. (May 2008)
In Kentucky, I-71 begins east of Downtown Louisville at the Kennedy Interchange, where it meets I-64 and I-65. This interchange is sometimes called the "Spaghetti Junction". From Louisville, it roughly follows the Ohio River in a diagonal path toward Northern Kentucky. Between Louisville and Cincinnati, I-71 is largely a four-lane highway, except for the approach to Kentucky Speedway in Sparta in which it runs three lanes each way for about two miles (3.2 km).
Near the town of Carrollton, there are signs marking the location of a tragic accident that occurred on May 14, 1988, when a drunk driver was driving north in the southbound lanes and struck a church bus full of children and teenagers, causing the bus's fuel tank to ignite into flames and killing 27 people on board. It is one of the worst bus accidents in state and national history.
After having run 77 miles (124 km) from Louisville, I-71 merges with I-75 near Walton after which it intersects I-275, the Cincinnati beltway. After passing through Covington, the freeway crosses the Ohio River via the lower level of the Brent Spence Bridge (while the southbound direction uses the upper level) and continues into Cincinnati.
In Cincinnati, it splits immediately from I-75 and heads due east onto Fort Washington Way, where it continues through Downtown Cincinnati concurrently with U.S. Route 50 (US 50) for less than one mile (1.6 km). Just east of downtown, US 50 splits from I-71 and continues east; I-71 bends north and receives I-471, a spur from southeast of the city. I-71 then heads in a general northeast direction through urban Cincinnati and into its surrounding suburbs. After another interchange with the I-275 beltway, the freeway leaves the metropolitan area and heads toward Columbus. It continues northeast until it reaches South Lebanon, where it begins cutting east across the flat plains of southwest Ohio. The freeway crosses the Little Miami River on the Jeremiah Morrow Bridge, which is a continuous truss bridge and the tallest bridge in Ohio, at 239 feet (73 m) above the river. I-71 heads toward Columbus then intersects with the bypass I-270 before heading north into urban Columbus, where it junctions I-70. About a mile (1.6 km) north of the I-70 junction, it intersects with I-670. After another interchange with the I-270 bypass, the highway exits Columbus and continues north until near Delaware, where it again turns northeast. Beginning its path to Cleveland, I-71 enters the rolling farm country on the edges of the Allegheny Plateau. It continues in this fashion to Lodi/Westfield Center and its junction with I-76, which provides access to Akron and points east. Heading north to Medina, it meets the terminus of I-271. The highway then continues north into urban Cuyahoga County and Cleveland's suburbs, intersecting the Ohio Turnpike/I-80. Passing Cleveland Hopkins International Airport, I-71 meets I-480 and enters Cleveland's west side, continuing on to downtown. It junctions with State Route 176 (SR 176) and terminates at I-90 on the Innerbelt.
The first section of I-71 in Louisville opened in December 1966 between its terminus at Spaghetti Junction and Zorn Avenue, its first exit. Its junction with I-264 opened in July 1968, and the complete Kentucky portion of the Interstate was opened to the public in July 1969. At that point, it replaced US 42 as the primary link between Cincinnati and Louisville.
Much of I-71 in Ohio was intended to be SR 1. SR 1 was originally planned in the 1950s as a second Ohio Turnpike extending southwest to northeast across the state. It was planned to run from Cincinnati to Conneaut and connect with an extension built across the panhandle of Pennsylvania to the New York State Thruway. As the highway was being planned, the Federal Aid Highway Act of 1956 was enacted, and the project was converted from a toll road to a freeway. It was designated as SR 1, since the Interstate Highway numbering system had not yet been implemented. Portions of the freeway began to be completed and opened in 1959 with the new Interstate Highway funding, and they were marked as SR 1 as well as with their new Interstate Highway number. Since large gaps existed along the corridor where no freeway had yet been completed, existing two-lane or four-lane highways were also designated as SR 1 in order to complete the route. The SR 1 signage was removed in 1966 as the Interstate Highway numbers adequately marked the route by then and the state highway numbering was superfluous.
In Columbus, the portion of I-71 that bounds Worthington's eastern edge was originally called the North Freeway. Costing $13.8 million (equivalent to $92.2 million in 2020 ), it was constructed south from SR 161, arriving at 11th Avenue by August 1961. It took another year to construct the portion between 11th Avenue and 5th Avenue, mainly due to the need to construct a massive underpass under the Pennsylvania Railroad's Grogan Yard. Today, only two tracks cross the viaduct, and the rest of the structure supports a large, weedy field. By August 1962, the freeway had reached Fifth Avenue, and it reached downtown in November 1962.
I-71 was originally planned to follow the Innerbelt Freeway northward from its current northern terminus to the Cleveland Memorial Shoreway at Dead Man's Curve when I-90 was planned to continue westward from there along the Shoreway.
Upon its completion, I-71 replaced SR 3 as the primary highway link between Cincinnati, Columbus, and Cleveland.
Between 2004 and 2006, the interchange at milepost 121 in the far northern reaches of Columbus was reconstructed to allow access to the eastern extension of Gemini Place. Before that, it was a simple diamond interchange with SR 750 (Polaris Parkway).
In 1999, the state of Ohio began a 10-year, $500-million (equivalent to $745 million in 2020 ) project to improve I-71 between Columbus and Cleveland. The plans did not include widening the 25-mile (40 km) stretch in Delaware and Morrow counties, calling for patching that section instead. At that time, state transportation officials said they did not plan to widen that section for two reasons: Traffic studies didn't support the widening, and there was no money for the project. But Ohio Department of Transportation (ODOT) officials eventually gave in under pressure from elected officials and business owners to widen the remaining 25-mile (40 km) stretch of I-71 from just north of the US 36/SR 37 interchange in Delaware County to the Morrow–Richland county line. The reconstruction and widening on the last 25-mile (40 km) stretch of I-71 in Delaware and Morrow counties began in spring 2012, and the work was completed in mid-2015 at a cost of $144 million (equivalent to $156 million in 2020 ).
I-65 south – Nashville
|Southern terminus; I-65 exit 137|
|136C||Jefferson Street – Downtown||Southbound exit and northbound entrance; exit number follows I-65|
I-65 north (Toll Bridge) / I-64 west – Indianapolis, St. Louis
|Signed as exits 1A (I-64) and 1B (I-65) southbound; no exit numbers northbound; I-64 exit 6; I-65 exit 137|
I-64 east – Lexington
|Northbound exit and southbound entrance; I-64 exit 5A|
|4.966||7.992||5||I-264 (Watterson Expressway)||I-264 exit 23|
I-265 / KY 841 (Gene Snyder Freeway) to US 42
|Signed as exits 9A (south) and 9B (north); I-265 exit 35|
|Oldham||||14.488||23.316||14||KY 329 – Crestwood, Pewee Valley|
|||17.478||28.128||17||KY 146 – Buckner, Crestwood, Pewee Valley|
|||18.507||29.784||18||KY 393 – Buckner|
|La Grange||21.869||35.195||22||KY 53 – La Grange, Ballardsville|
KY 153 to KY 146 – Sligo, New Castle
|Campbellsburg||33.505||53.921||34||US 421 – Campbellsburg, New Castle, Bedford|
| Trimble ||No major junctions|
KY 389 to KY 55 – Prestonville, English
|||44.312||71.313||44||KY 227 – Worthville, Carrollton|
KY 1039 to KY 465 – Vevay
|Serves Kentucky Speedway|
|||56.673||91.206||57||KY 35 – Sparta, Warsaw|
|Glencoe||61.774||99.416||62||US 127 – Glencoe, Owenton|
|Boone||||72.195||116.187||72||KY 14 – Verona|
I-75 south – Lexington
|Southern end of I-75 overlap; exit numbers switch to follow I-75's mileposts, I-75 exit 173|
|||79.556||128.033||175||KY 338 – Richwood|
|Florence||82.275||132.409||178||KY 536 (Mt. Zion Road)|
|84.298||135.664||180||US 42 / US 127 – Union, Florence|
|84.694||136.302||180A||Mall Road||Southbound exit and northbound entrance; serves Florence Mall; former KY 3157|
|85.449||137.517||181||KY 18 – Florence, Burlington|
|86.652||139.453||182||KY 1017 (Turfway Road)|
|Kenton||Erlanger||87.967||141.569||184||KY 236 – Erlanger||Signed as exits 184A (east) and 184B (west) southbound|
I-275 to I-471 – Cincinnati/Northern Kentucky International Airport
|I-275 exit 84|
|Fort Mitchell||90.539||145.708||186||KY 371 (Buttermilk Pike)|
|91.913||147.920||188||US 25 / US 42 / US 127 (Dixie Highway) – Fort Mitchell|
|Fort Wright||92.870||149.460||189||KY 1072 (Kyles Lane) – Fort Wright, Park Hills|
|191||12th Street (KY 1120), Pike Street (US 25 / US 42 / US 127) – Covington|
|192||5th Street (KY 8) – Covington, Newport|
| Brent Spence Bridge |
I-75 north / US 50 west – Dayton
|Northern end of I-75 overlap; southern end of US 50 overlap|
|1B||Second Street – Downtown, Riverfront||Exit unnumbered until 2018|
US 50 east (Columbia Parkway) to I-471 / US 52
|Northeren end of US 50 overlap; northbound exit and southbound entrance|
| Lytle Tunnel |
Sharp turn (40 mph or 64 km/h) in both directions
I-471 south – Newport
|Southbound exit and northbound entrance; exit unnumbered until 2018|
|2||US 42 (Reading Road) / Eden Park Drive / Gilbert Avenue (US 22 / SR 3) / Eighth Street – Ballpark, Stadium/Arena||Split into exit 2A (US 42) and 2B (Gilbert/8th) southbound; Gilbert Ave./8th St. not signed northbound, Eden Park Dr. not signed southbound|
|McMillan Street||Northbound entrance only|
|3A||William Howard Taft Road||Southbound exit only|
|3B||Martin Luther King Drive – Level I Trauma Center||Signed as exit 3 northbound|
|5||Dana Avenue / Montgomery Road (US 22 / SR 3)|
|6||SR 561 (Smith Road / Edwards Road)|
|Cincinnati||8.04||12.94||8A||Ridge Avenue south||Northbound exit and southbound entrance|
|8B||SR 562 – Norwood||Signed as exit 7 southbound|
|Columbia Township||8.51||13.70||8C||Ridge Avenue north||Northbound exit and southbound entrance|
|8.75||14.08||8||Kennedy Avenue, Ridge Avenue||Southbound exit and northbound entrance|
|9||Red Bank Road – Fairfax|
|Silverton||10.68||17.19||10||Stewart Road||Northbound exit and southbound entrance|
|Sycamore Township||11.81||19.01||11||Kenwood Road||Northbound exit and southbound entrance|
|12.44||20.02||12||US 22 / SR 3 (Montgomery Road)|
|Montgomery||14.13||22.74||14||SR 126 (Ronald Reagan Cross County Highway)|
I-275 to SR 32 / I-75
|I-275 exit 49; signed as exits 17A (east) & 17B (west) southbound|
| Hamilton–Warren |
| Symmes–Deerfield |
|19||Mason Montgomery Road / Fields Ertel Road|
|Warren||Mason||23.53||37.87||24||Western Row Road / Kings Island Drive / Innovation Way – Kings Island||Signed as Western Row Road and Kings Island Drive northbound and Western Row Road and Innovation Way southbound; originally constructed as northbound exit and southbound entrance only but expanded to a full interchange in 2019|
SR 741 north (Kings Mills Road) – Mason, Kings Mills, Kings Island
| Lebanon–South Lebanon |
|28.33||45.59||28||SR 48 – South Lebanon, Lebanon|
|Turtlecreek Township||32.56||52.40||32||SR 123 – Morrow, Lebanon|
|Washington Township||36.74||59.13||36||Wilmington Road|
|Clinton||Chester Township||45.11||72.60||45||SR 73 – Waynesville, Wilmington|
|50||US 68 – Xenia, Wilmington|
|Greene||Jefferson Township||58.01||93.36||58||SR 72 – Sabina, Jamestown|
|Fayette||Octa||65.33||105.14||65||US 35 (SR 435) – Xenia, Washington Court House|
|Jeffersonville||69.49||111.83||69||SR 41 / SR 734 – South Solon, Jeffersonville, Washington Court House|
|Paint Township||75.03||120.75||75||SR 38 – Bloomingburg, Midway|
|Madison||Pleasant Township||84.27||135.62||84||SR 56 – Mount Sterling, London|
| Pickaway ||No major junctions|
|Franklin||Pleasant Township||94.15||151.52||94||US 62 / SR 3 – Grove City, Orient, Harrisburg|
|Jackson Township||97.16||156.36||97||SR 665 (London-Groveport Road)||Interchange fully opened August 17, 2012|
|Grove City||98.85||159.08||99||Hoover Road – Grove City||Proposed|
|100.60||161.90||100||Stringtown Road – Grove City|
|Jackson Township||101.68||163.64||101||I-270 – Dayton, Wheeling||Signed northbound as exit 100, southbound as exit 101; I-270 exit 55|
|Columbus||103.86||167.15||104||SR 104 / Frank Road|
I-70 west – Dayton
|Northbound exit and southbound entrance; I-70 exit 99A|
SR 315 north – Worthington
|No exit number southbound; I-70 exit 99B|
I-70 west – Dayton
|Southern end of I-70 overlap; southbound exit and northbound entrance; I-70 exit 99A; exit numbers switch to follow I-70's mileposts|
|US 23 (Third Street / Fourth Street) / Fulton Street||New interchange to replace exits 100A-B; to have no southbound exit|
US 23 south (High Street) / Front Street
|No northbound entrance; southbound exit is via exit 100B|
US 23 north (Fourth Street) / Livingston Avenue (US 33)
|101B||Parsons Avenue||Northbound exit only|
|Northern end of I-70 overlap; I-70 exit 101A ; left exit southbound|
|108.20||174.13||108A||Main Street||No northbound exit|
|108.63||174.82||108B||US 40 (Broad Street)||Southbound entrance and northbound exit|
|109.16||175.68||109A||I-670 – Airport, Dayton||Northbound exit and southbound entrance; I-670 exit 5; northbound off-ramp to I-670 east includes direct ramp onto Leonard Avenue|
|108.93||175.31||109B||Spring Street – Downtown||Southbound exit and northbound entrance|
|109.61||176.40||109A||I-670 – Airport, Dayton||Southbound exit and northbound entrance; I-670 exit 5|
|110.16||177.29||110A||Fifth Avenue||No northbound exit|
|110.68||178.12||110B||11th Avenue||Access to Linden Primary Care Center|
|111.15||178.88||111||17th Avenue||Access to the Ohio State Fairgrounds & Expo Center and Ohio History Center|
|113.46||182.60||114||North Broadway||Access to Riverside Methodist Hospital|
|114.53||184.32||115||Cooke Road (Indianola Avenue)|
|115.58||186.01||116||Morse Road / Sinclair Road|
|117.53||189.15||117||SR 161 (Dublin-Granville Road)|
|119||I-270 – Dayton, Wheeling||Signed as exits 119A (east) and 119B (west) southbound; I-270 exit 26|
| Franklin–Delaware |
SR 750 west (Polaris Parkway) / Gemini Place / Ikea Way
|Eastern terminus of SR 750; access to Polaris Shopping Center|
|Delaware||Orange Township||124||200||Big Walnut Road||Future interchange|
|Berkshire Township||Sunbury Parkway||Future interchange|
|130.64||210.24||131||US 36 / SR 37 – Delaware, Sunbury|
|Morrow||Bennington Township||140.15||225.55||140||SR 61 – Sunbury, Mount Gilead, Galion|
| Chester–Franklin |
|151.09||243.16||151||SR 95 – Fredericktown, Mount Gilead|
|Richland|| Washington Township–Bellville |
|165.25||265.94||165||SR 97 – Lexington, Bellville|
| Washington Township–Mansfield |
|168.81||271.67||169||SR 13 – Mansfield, Bellville|
|Madison Township||172.97||278.37||173||SR 39 – Mansfield, Lucas|
|Mifflin Township||176.91||284.71||176||US 30 – Mansfield, Wooster||Indirect southbound access to eastbound US 30 and from westbound US 30 to northbound I-71 via Crider and Koogle roads|
|Ashland||Montgomery Township||186.71||300.48||186||US 250 – Ashland, Wooster|
|Wayne||Congress Township||196.31||315.93||196||SR 301 – West Salem||Northbound exit and southbound entrance|
|197.92||318.52||198||SR 539 – West Salem, Congress|
|Medina||Harrisville Township||203.89||328.13||204||SR 83 – Lodi, Wooster|
|Westfield Township||209.51||337.17||209||I-76 / US 224 – Lodi, Akron||Signed as exits 209A (I-76/US 224 east) and 209B (US 224 west); western terminus of I-76 (Ohio), exit 1|
|Medina Township||218.86||352.22||218||SR 18 – Akron, Medina|
I-271 north – Erie
|Northbound exit and southbound entrance|
|222.91||358.74||222||SR 3 – Hinckley, Medina|
|Brunswick||226.03||363.76||226||SR 303 – Brunswick, Hinckley|
|Cuyahoga||Strongsville||231.26||372.18||231||SR 82 (Royalton Road) – Strongsville, North Royalton||Signed as exits 231A (east) and 231B (west) southbound|
|233.06||375.07||233||I-80 / Ohio Turnpike – Toledo, Youngstown||I-80/Ohio Turnpike exit 161|
|Middleburg Heights||234.21||376.92||234||US 42 – Strongsville, Parma Heights|
|235.37||378.79||235||Bagley Road – Berea, Middleburg Heights|
|Brook Park||237.53||382.27||237||Snow Road / Engle Road – Airport||Signed as exits 237A (east) and 237B (west, Engle) southbound|
|Brook Park–Cleveland line||238.77||384.26||238||I-480 – Airport, Toledo, Youngstown||Northbound exit and southbound entrance; I-480 exit 11|
SR 237 south – Airport, Berea
|Southbound left exit and northbound left entrance|
|240.57||387.16||240||W. 150th Street|
|241.85||389.22||242A||W. 130th Street||Signed as exit 242 southbound|
|Cleveland–Linndale line||242.41||390.12||242B||Bellaire Road||Northbound exit and southbound entrance|
|Cleveland||244.5||393.5||244||Denison Avenue / W. 65th Street||Northbound exit and southbound entrance|
|245||US 42 (SR 3 / Pearl Road / W. 25th Street) / Fulton Road|
SR 176 south – Parma
|Southbound exit and northbound entrance|
I-90 west / I-490 east / W. 14th Street / Clark Avenue / Steelyard Drive
|Northbound exit and southbound entrance; I-90 exit 170B; I-490 exit 1A|
I-90 east – Downtown Cleveland
|Northern terminus; I-90 exit 170B|
|1.000 mi = 1.609 km; 1.000 km = 0.621 mi|
I-71 has two auxiliary routes in the Cleveland metropolitan area and in the Cincinnati metropolitan area. I-471 links downtown Cincinnati with I-275. I-271 provides access to Cleveland's eastern suburbs and enables travelers on I-71 to access I-90 east without going through Cleveland proper.
Interstate 10 (I-10) is the southernmost cross-country highway in the American Interstate Highway System. I-10 is the fourth-longest Interstate in the United States at 2,460.34 miles (3,959.53 km), following I-90, I-80, and I-40. This freeway is part of the originally planned network that was laid out in 1956, and its last section was completed in 1990.
Interstate 75 (I-75) is a major north–south Interstate Highway in the Great Lakes and Southeastern regions of the United States. As with most Interstates that end in 5, it is a major cross-country, north–south route, traveling from State Road 826 and SR 924 on the Hialeah–Miami Lakes border to Sault Ste. Marie, Michigan, at the Canadian border. It is the second-longest north–south Interstate Highway and the seventh-longest Interstate Highway overall.
U.S. Route 27 (US 27) is a north–south United States Highway in the southern and midwestern United States. The southern terminus is at US 1 in Miami, Florida. The northern terminus is at Interstate 69 (I-69) in Fort Wayne, Indiana. From Miami it goes up the center of Florida, then west to Tallahassee, Florida, and north through such cities and towns as Columbus, Georgia; Rome, Georgia; Chattanooga, Tennessee; Lexington, Kentucky; Cincinnati, Ohio; Oxford, Ohio; Richmond, Indiana; and Fort Wayne, Indiana. It once extended north through Lansing, Michigan, to Cheboygan, Mackinaw City, and for about three years even as far as St. Ignace. US 27 was first signed in 1926, replacing what had been the eastern route of the Dixie Highway in many states.
Interstate 215 (I-215) is a 54.5-mile-long (87.7 km) north–south auxiliary Interstate Highway in the Inland Empire region of the San Bernardino–Riverside urban area in Southern California. It has portions designated as the Barstow, Escondido, and Armed Forces Freeways. I-215 is a bypass auxiliary route of I-15, running from Murrieta to northern San Bernardino. While I-215 connects the city centers of both Riverside and San Bernardino, its parent I-15 runs to the west through Corona and Ontario.
U.S. Route 31 or U.S. Highway 31 (US 31) is a major north–south U.S. highway connecting southern Alabama to northern Michigan. Its southern terminus is at an intersection with US 90/US 98 in Spanish Fort, Alabama. Its northern terminus is at an interchange with Interstate 75 (I-75) south of Mackinaw City, Michigan.
U.S. Route 23 or U.S. Highway 23 is a major north–south U.S. Highway between Jacksonville, Florida, and Mackinaw City, Michigan. It is an original 1926 route which originally reached only as far south as Portsmouth, Ohio, and has since been extended. It was formerly part of the major highway known as the Dixie Highway. The highway's southern terminus is in Jacksonville, Florida at US 1/US 17. The northern terminus is at I-75 in Mackinaw City, Michigan.
U.S. Route 42 is an east–west United States highway that runs southwest–northeast for 350 miles (560 km) from Louisville, Kentucky to Cleveland, Ohio. The route has several names including Pearl Road from Cleveland to Medina in Northeast Ohio, Reading Road in Cincinnati, Cincinnati and Lebanon Pike in southwestern Ohio and Brownsboro Road in Louisville. Traveling northeast, the highway ends in downtown Cleveland and traveling southwest ends in Louisville.
Interstate 471 (I-471) is a 5.75-mile-long (9.25 km) Interstate Highway, linking I-71 in Downtown Cincinnati, Ohio, to I-275 in Highland Heights, Kentucky. South of I-275, the expressway continues south to U.S. Route 27 (US 27) as unsigned Kentucky Route 471 (KY 471).
Interstate 475 (I-475) is an auxiliary Interstate Highway in Ohio that is a 20.37-mile (32.78 km) western bypass of Toledo. The southern terminus is I-75 exit 192 near Perrysburg. From the southern terminus to exit 14, I-475 is cosigned with US Route 23 (US 23) and is signed the north–south section of I-475. From exit 14 to the eastern (northernmost) terminus at I-75 exit 204 in central Toledo, it is signed the east–west section of I-475.
Interstate 264 (I-264) is a partial loop around the city of Louisville, Kentucky, south of the Ohio River. An auxiliary route of I-64, it is signed as the Shawnee Expressway for its first eight miles (13 km) from its western terminus at I-64/U.S. Route 150 (US 150) to US 31W/US 60 and as the Watterson Expressway for the remainder of its length from US 31W/US 60 to its northeastern terminus at I-71. It is 22.93 miles (36.90 km) in length and runs an open circle around central Louisville. The highway begins four miles (6.4 km) west of Downtown Louisville at I-64 just east of the Sherman Minton Bridge, which links Southern Indiana with Kentucky as it crosses the Ohio River. The Interstate ends approximately six miles (9.7 km) northeast of Downtown Louisville, where it connects to I-71.
Interstate 265 (I-265) is a 41.8-mile (67.3 km) Interstate Highway partially encircling the Louisville metropolitan area. Starting from I-65 in the southern part of Louisville, it runs through Jefferson County, Kentucky, crosses the Ohio River on the Lewis and Clark Bridge into Indiana, meets I-65 for a second time, and then proceeds westbound to terminate at the I-64 interchange.
State Route 59 is an east–west state highway in the U.S. state of Ohio, serving the Akron metropolitan area. The western terminus of State Route 59 is in downtown Akron at a partial interchange with the Interstate 76/Interstate 77 concurrency, and the eastern terminus is at State Route 5, 0.5 miles (0.80 km) east of Ravenna. The route is approximately 23 miles (37 km) long and was certified in 1969 over what had previously been part of SR 5. It serves as a major or as the primary east–west roadway for the cities of Cuyahoga Falls, Kent, Ravenna, and Stow, the village of Silver Lake, and Franklin and Ravenna Townships.
State Route 315, known locally as the Olentangy Freeway, running almost parallel to Olentangy River Road for most of its length, is a north–south highway in central Ohio, in the Columbus metropolitan area. It may be seen abbreviated as SR 315, OH-315, or simply 315. Its southern terminus is at the south junction of I-70 and I-71 in Columbus, and its northern terminus is at US 23 near Delaware. It is a controlled access freeway from its southern terminus to I-270. The controlled access section carries two or three lanes in each direction, depending on the location. North of I-270, it becomes a two-lane road. It roughly follows the Olentangy River for about two-thirds of its length. The route passes through The Ohio State University campus. The section between Interstate 670 and Interstate 70 is known as the West Innerbelt, and it is commonly referred to as such in traffic reports. The original name of this section was Sandusky Street.
U.S. Route 422 (US 422) is a 271-mile (436 km) long spur route of US 22 split into two segments in the U.S. states of Ohio and Pennsylvania. The western segment of US 422 runs from downtown Cleveland, Ohio, east to Ebensburg, Pennsylvania. The eastern segment, located entirely within Pennsylvania, runs from Hershey east to King of Prussia, near Philadelphia. US 422 Business serves as a business route into each of four towns along the way.
State Route 10 is a state highway located in and around Cleveland, Ohio. The current routing of SR 10 was certified in 1934. The route's western terminus is in Eaton Township in Lorain County at the junction of U.S. Route 20, State Route 57 and State Route 301, where US 20 and SR 301 continue westbound on the freeway. In North Ridgeville, route 10 merges with Interstate 480 at the interstate's western terminus in North Ridgeville, and continues with the interstate briefly eastward. Just east of this junction, the route also has an interchange with Interstate 80 and the Ohio Turnpike via a connecting or spur road. SR 10 then becomes a grade-level road in North Ridgeville before heading into Cuyahoga County, and is known as Lorain Road. It then continues through the western suburbs of Cleveland and through the western part of Cleveland, as Lorain Avenue, terminating shortly after it crosses the Cuyahoga River on the Hope Memorial Bridge at Gateway at Broadway Avenue/Ontario Street.
Interstate 65 (I-65) in the US state of Indiana traverses from the south-southeastern Falls City area bordering Louisville, Kentucky, through the centrally located capital city of Indianapolis, to the northwestern Calumet Region of the Hoosier State which is part of the Chicago metropolitan area. The Indiana portion of I-65 begins in Jeffersonville after crossing the Ohio River and travels mainly north, passing just west of Columbus prior to reaching the Indianapolis metro area. Upon reaching Indianapolis, the route alignment of I-65 begins to run more to the northwest and subsequently passes Lafayette on that city's east and north sides. Northwest of there, in west-central Jasper County, the route again curves more northward as it approaches the Calumet Region. Shortly after passing a major junction with I-80 and I-94, I-65 reaches its northern national terminus in Gary at I-90 which is carried on the Indiana East–West Toll Road. I-65 covers 261.27 miles (420.47 km) in the state of Indiana. This is one of the principal Interstate Highways that cross the state, and, more specifically, intersect at the city of Indianapolis, that has given the state the nickname of "Crossroads of America".
U.S. Route 50 runs east–west across the southern part of the state of Ohio, passing through Cincinnati, Chillicothe, and Athens. It is mainly a two-lane road except for the easternmost and westernmost parts. Near Athens it runs concurrently with State Route 32 (SR 32), a four-lane divided highway known as Corridor D, and from Coolville to the Ohio–West Virginia border it also overlaps SR 7 before crossing into Parkersburg, West Virginia.
Interstate 75 (I-75) runs from Cincinnati to Toledo by way of Dayton in the US state of Ohio. The highway enters the state running concurrently with I-71 from Kentucky on the Brent Spence Bridge over the Ohio River and into the Bluegrass region. I-75 continues along the Mill Creek Expressway northward to the Butler County line just north of I-275. From there, the freeway runs into the Miami Valley and then passes through the Great Black Swamp before crossing into Michigan.
Interstate 64 (I-64) in the US state of Kentucky travels for 191 miles (307 km), passing by the major towns and cities of Louisville, Frankfort, Lexington, and Ashland. It has several major junctions with other Interstates, including I-65, I-71, I-264, and I-265 in Louisville and I-75 in Lexington.
U.S. Route 23 (US 23) is a United States Numbered Highway that runs from Jacksonville, Florida, to Mackinaw City, Michigan. In the state of Ohio, it is a major north–south state highway that runs from the Kentucky border at Portsmouth to the Michigan border at Sylvania.