Paul Edmonds (patient)

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Paul Edmonds

Paul Edmonds, is an American recognized as the oldest individual to achieve remission from both HIV and leukemia. He is known as the "City of Hope Patient" from the hospital where he underwent treatment in Duarte, California. Diagnosed with HIV in 1988 at the age of 33, Edmonds spent over three decades living with the virus until 2018, when he faced a new challenge—a diagnosis of myelodysplastic syndrome, evolving into acute myelogenous leukemia. His journey to recovery, culminating in a stem cell transplant in 2019, at age 63, involved a donor with a rare genetic mutation (homozygous CCR5 Delta 32) resistant to most HIV strains. Edmonds ceased his HIV treatment in March 2021, with subsequent tests revealing no evidence of HIV in his body. [1] [2] [3] [4] [5] Edmonds is among the five known individuals cured of HIV through stem cell transplantation for their blood cancer, alongside the Berlin Patient, [6] [7] London Patient, [8] Düsseldorf Patient, [9] and New York Patient. [10]

See also

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References

  1. ↑ "After decades under a virus's shadow, he now lives free of HIV". Washington Post. 2023-04-03. Retrieved 2024-02-15.
  2. ↑ "Paul Edmonds, 5th person apparently cured of HIV, steps forward to share his story - ABC News". ABC News . 2024-02-15. Archived from the original on 2024-02-15. Retrieved 2024-02-15.
  3. ↑ "HIV in remission: California man Paul Edmonds 1 of 5 patients cured". USA Today . 2024-02-15. Archived from the original on 2024-02-15. Retrieved 2024-02-15.
  4. ↑ "City of Hope Research Featuring the Successful Treatment of the Oldest Patient to Achieve Remission for Leukemia and HIV Published in The New England Journal of Medicine (NEJM)". 2024-02-15. Archived from the original on 2024-02-15. Retrieved 2024-02-15.
  5. ↑ Dickter, Jana K.; Aribi, Ahmed; Cardoso, Angelo A.; Gianella, Sara; Gendzekhadze, Ketevan; Li, Shirley; Feng, Ye; Chaillon, Antoine; Laird, Gregory M.; Browning, Diana L.; Ross, Justine A.; Nanayakkara, Deepa D.; Puing, Alfredo; Stan, Rodica; Lai, Lily L. (2024-02-15). "HIV-1 Remission after Allogeneic Hematopoietic-Cell Transplantation". New England Journal of Medicine. 390 (7): 669–671. doi:10.1056/NEJMc2312556. ISSN   0028-4793. PMC  10906479. PMID   38354149.
  6. ↑ Brown, Timothy Ray (January 2015). "I Am the Berlin Patient: A Personal Reflection". AIDS Research and Human Retroviruses. 31 (1): 2–3. doi:10.1089/aid.2014.0224. ISSN   0889-2229. PMC   4287108 . PMID   25328084.
  7. ↑ Hütter, Gero; Nowak, Daniel; Mossner, Maximilian; Ganepola, Susanne; Müßig, Arne; Allers, Kristina; Schneider, Thomas; Hofmann, Jörg; Kücherer, Claudia; Blau, Olga; Blau, Igor W.; Hofmann, Wolf K.; Thiel, Eckhard (2009-02-12). "Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation". New England Journal of Medicine. 360 (7): 692–698. doi:10.1056/NEJMoa0802905. ISSN   0028-4793. PMID   19213682.
  8. ↑ Gupta, Ravindra Kumar; Peppa, Dimitra; Hill, Alison L; Gálvez, Cristina; Salgado, Maria; Pace, Matthew; McCoy, Laura E; Griffith, Sarah A; Thornhill, John; Alrubayyi, Aljawharah; Huyveneers, Laura E P; Nastouli, Eleni; Grant, Paul; Edwards, Simon G; Innes, Andrew J (May 2020). "Evidence for HIV-1 cure after CCR5Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report". The Lancet HIV. 7 (5): e340–e347. doi:10.1016/s2352-3018(20)30069-2. ISSN   2352-3018. PMC   7606918 . PMID   32169158.
  9. ↑ Jensen, Björn-Erik Ole; Knops, Elena; Cords, Leon; Lübke, Nadine; Salgado, Maria; Busman-Sahay, Kathleen; Estes, Jacob D.; Huyveneers, Laura E. P.; Perdomo-Celis, Federico; Wittner, Melanie; Gálvez, Cristina; Mummert, Christiane; Passaes, Caroline; Eberhard, Johanna M.; Münk, Carsten (March 2023). "In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation". Nature Medicine. 29 (3): 583–587. doi:10.1038/s41591-023-02213-x. ISSN   1546-170X. PMC   10033413 . PMID   36807684.
  10. ↑ Hsu, Jingmei; Van Besien, Koen; Glesby, Marshall J.; Pahwa, Savita; Coletti, Anne; Warshaw, Meredith G.; Petz, Lawrence D.; Moore, Theodore B.; Chen, Ya Hui; Pallikkuth, Suresh; Dhummakupt, Adit; Cortado, Ruth; Golner, Amanda; Bone, Frederic; Baldo, Maria (March 2023). "HIV-1 remission and possible cure in a woman after haplo-cord blood transplant". Cell. 186 (6): 1115–1126.e8. doi:10.1016/j.cell.2023.02.030. ISSN   0092-8674. PMC   10616809 . PMID   36931242.
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