Pre-exposure prophylaxis for HIV prevention

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Tablets of Truvada, a tenofovir/emtricitabine combination used for HIV pre-exposure prophylaxis Truvada.JPG
Tablets of Truvada, a tenofovir/emtricitabine combination used for HIV pre-exposure prophylaxis

Pre-exposure prophylaxis for HIV prevention, commonly known as PrEP, is the use of antiviral drugs as a strategy for the prevention of HIV/AIDS by people that do not yet have HIV/AIDS. [1] PrEP is one of a number of HIV prevention strategies for people who are HIV-negative but who have a higher risk of acquiring HIV, including sexually-active adults who are at increased risk of contracting HIV, people who engage in intravenous drug use (see drug injection), and serodiscordant sexually-active couples. [2]

Contents

The first form of PrEP for HIV prevention—emtricitabine and tenofovir disoproxil (FTC/TDF; Truvada)—was approved in 2012. [3] In October 2019, the U.S. Food and Drug Administration (FDA) approved the combination of emtricitabine and tenofovir alafenamide (FTC/TAF; Descovy) to be used as PrEP in addition to Truvada, which provides similar levels of protection. [4] Descovy, however, is currently approved only for cisgender males and transgender women as the efficacy has not been assessed in people at risk for HIV through receptive vaginal sex. [2]

In December 2021, the FDA approved cabotegravir (Apretude), which is an injectable form of PrEP manufactured by Viiv Healthcare. Regulators believe it will improve medication adherence because it has to be taken just once every two months, and it will also widen adoption as it eliminates the need to hide pills or pharmacy visits for discretion. [5]

In its 2021 guidelines, the World Health Organization (WHO) recommends multiple forms of PrEP for HIV prevention: [6]

This article provides information regarding PrEP's medical uses, contraindications and side effects, societal and cultural perspectives on its usage, and recent research studies.

Medical uses

Indications for use

United States

In the United States, federal guidelines updated in 2021 now recommend healthcare providers discuss and provide information on the use of pre-exposure prophylaxis (PrEP) for HIV prevention for all sexually active adults and adolescents. [2] The Centers for Disease Control and Prevention (CDC) recommends providers take a targeted sexual history of their patients to assess specific risk for HIV acquisition and suggest PrEP to the following patients: [2]

  • Sexually active adults and adolescents who have had anal or vaginal sex in the past 6 months and any of the following:
    • 1 or more partner(s) with unknown HIV status and inconsistent condom use;
    • An HIV-positive sexual partner (especially if they have an unknown or detectable viral load);
    • A bacterial sexually transmitted infection (STI) in the past 6 months.
  • Patients reporting injection drug use within the last 6 months and any of the following:
    • An HIV-positive injecting partner;
    • Shared injection equipment.

Additionally, these updated guidelines recommend providers prescribe PrEP to any patient that requests it, regardless of their stated risk factors. [2]

United Kingdom

In the United Kingdom the BHIVA/BASHH guidelines on the use of HIV pre-exposure prophylaxis (PrEP) 2018 [7] recommend:

  • On-demand or daily oral Tenofovir – emtricitabine (TD-FTC) for HIV-negative MSM who are at elevated risk of HIV acquisition through unprotected anal sex in the previous six months and ongoing unprotected anal sex.
  • On-demand or daily oral TD-FTC for HIV-negative MSM having unprotected anal sex with partners who are HIV positive, unless the partner has been on ART for at least six months and their plasma viral load is <200 copies/mL.
  • Tenofovir (TDF) alone should not be offered to MSM.
  • Daily oral TD-FTC for HIV-negative heterosexual men and women having unprotected sex with partners who are HIV positive, unless the partner has been on ART for at least six months and their plasma viral load is <200 copies/mL.
  • Daily oral TD-FTC for heterosexual men and women on a case-by-case basis with current factors that may put them at increased risk of HIV acquisition.
  • TDF alone can be offered to heterosexual men and women where FTC is contraindicated.
  • PrEP is not recommended for people who inject drugs where needle exchange and opiate substitution programs are available and accessed by the individual.
  • PrEP with daily oral TD-FTC for HIV-negative trans women who are at risk of HIV acquisition through unprotected anal sex in the previous six months and ongoing unprotected sex.
  • Daily oral TD-FTC for HIV-negative trans women and trans men who have unprotected sex with partners who are HIV positive, unless the partner has been on ART for at least six months and their plasma viral load is <200 copies/mL.

Other Countries

Other government health agencies from around the world have devised their own national guidelines for how to use PrEP to prevent HIV infection in those at high risk, including Botswana, Canada, Kenya, Lesotho, South Africa, Uganda, the Zambia, and Zimbabwe. [8]

Eligibility, follow-up care, dosage

Per WHO guidelines, initiation of PrEP can be done if a person tests negative for HIV, has no signs of current HIV infection, has good kidney function (creatinine clearance >30 ml/min4) and no contraindications to the medication. [2] Once PrEP is initiated, individuals are asked to see their healthcare provider at least every three to six months. During those visits, providers should repeat testing for HIV, test for other sexually transmitted infections, monitor kidney function, and/or test for pregnancy. [9] [2] Individuals must test negative for HIV prior to PrEP initiation because persons infected with HIV taking PrEP medication are at risk for becoming resistant to emtricitabine. Consequently, people with HIV infection and resistance to emtricitabine will have fewer options for selecting HIV treatment medications. [10]

A bottle of a generic version of emtricitabine/tenofovir, used for PrEP A bottle of a generic version of Truvada.jpg
A bottle of a generic version of emtricitabine/tenofovir, used for PrEP

Oral PrEP is typically taken daily following potential exposure. The CDC recommends follow-up visits at least every three months to provide HIV tests, medication adherence counseling, behavioral risk reduction support, side effect assessment, STI symptom assessment, and STI testing for sexually active individuals with symptoms of a current infection. [2] Pregnancy tests should also be done every three months for woman who may become pregnant. [2] At three months and every six months thereafter, renal function and presence of bacterial STI is assessed. [11] [2] Effectiveness of PrEP is associated with adherence, meaning the more consistently a person takes the medication as prescribed the greater the chance at reducing their risk for HIV. [12]

Injectable PrEP (Cabotegravir) follows similar guidelines for eligibility and initiation criteria as oral PrEP medications. [2] However, instead of daily dosing, people who use injectable forms of PrEP will received one initial dose following a second dose after 1 month. [2] They can repeat dosing every 2 months after. Follow-up testing includes repeat HIV testing and STI screening. Those who decide to discontinue injectable PrEP may begin using oral PrEP within 2 months of their last injection. [2]

PrEP has been shown to be effective at reducing the risk of acquiring HIV in individuals at increased risk. [9] Studies evaluating PrEP efficacy to reduce risk of HIV infection found a linear relationship between adherence and effectiveness of medication. This means that the more closely people follow recommended dosing of PrEP, the more effective the medication is at preventing infection. [13] However, PrEP is not 100% effective at preventing HIV, even in people who take the medication as prescribed. [14] There have been several reported cases of people who acquired HIV despite taking PrEP. [15] People taking PrEP may use combination prevention strategies along with PrEP, such as condoms and other protective barriers methods. [9] If someone on PrEP acquires HIV, they may experience the signs and symptoms of HIV/AIDS. [16]

Event-driven PrEP

Although the daily, oral dosing schedule is still recommended for all individuals taking PrEP medication for HIV infection prevention, event-driven pre-exposure prophylaxis, or ED-PrEP, is an option for men who have sex with men. ED-PrEP is also referred to as "2+1+1" dosing, because the dosing regimen involves a person taking two pills two to twenty-four hours prior to sex, one pill twenty-four hours after taking the first two pills, and a last pill taken forty-eight hours after taking the first two pills. [17] This dosing regimen was first proven effective to reduce the relative risk of HIV infection by 86% in the IPERGAY randomized clinical trial performed in Canada and France in 2015. [18] This has only been evaluated with Truvada and not other drugs. According to the WHO, ED-PrEP should be considered for HIV infection prevention in men who have sex with men who have relatively infrequent sex, who are able to plan sex or delay sex for about two hours, and who find this dosing schedule convenient. ED-PrEP is not recommended for use in other populations, such as women and men who have sex with cisgender women, due to the lack of safety and efficacy data available. [18] ED-PrEP can be beneficial to help reduce the pill burden for people and decrease costs, as fewer pills are needed. [19]

PrEP During Pregnancy and Postpartum

The World Health Organization (WHO) recommendations support the use of PrEP in pregnant and breastfeeding people who are at substantial risk of HIV infection. [2] [6] [20] A growing body of evidence demonstrates the safety of TDF-containing oral PrEP during pregnancy and breastfeeding. This is an important time for prevention, as acquiring HIV during pregnancy increases the risk of transmission to the infant. [6] Global oral PrEP accessibility for women, including those who are either pregnant or breastfeeding, is limited. In addition, there is minimal research on the effects of injectable PrEP and pregnancy outcomes. [21] Efforts to increase accessibility to women who are at risk for HIV are necessary for reducing rates of global HIV infections. [22]

Contraindications

Truvada and Descovy

Truvada and Descovy are contraindicated for use as pre-exposure prophylaxis (PrEP) in individuals who have an unknown or positive HIV status. [2] [23] [24] HIV positive or negative status must be determined before someone begins the use of either of these medications as PrEP. [23] [24] Additionally, any hypersensitivity or severe allergy to any ingredient, emtricitabine, tenofovir disoproxil, or tenofovir alafenamide is a contraindication for continued use of these medications. [23] [24]

Side effects

Research shows that pre-exposure prophylaxis (PrEP) is generally safe and well tolerated for most individuals, although some side effects have been noted to occur.

Initial side effects may be experienced called "start-up syndrome." This includes nausea/abdominal pain, headaches, weight loss and/or diarrhea, which generally resolve within a few weeks of starting the PrEP medication. [2] [9] [25]

Research has shown that the use of Truvada has been associated with mild to moderate declines in kidney function, mostly associated with older people over 50, those with predisposing conditions such as diabetes, or glomerular filtration rate lower than 90. [26] [23] [27] These declines were usually of no concern, stabilized after several weeks of being on the drug, and reversed once the drug was discontinued. [28] [29] In addition, a recent meta-analysis indicated no change in hepatic or renal function in patients using PrEP. [30] However, some of these side effects were serious enough for several people on PrEP to file lawsuits against the makers of Truvada as well as the makers of other similar drugs. [31] [32] [33]

While osteopenia or bone loss was reported in clinical studies, it was considered minimal and did not lead to osteoporosis. [34] [35] When comparing bone fractures between active participants and control groups there was no significant difference in bone fractures. [35]

Fat redistribution and accumulation was more commonly seen in individuals receiving antiretroviral therapy, particularly older antiretrovirals, for the treatment of HIV. [36] No significant changes in fat redistribution or change in fat had been noted when used as a pre-exposure prophylaxis. Research and study outcome analysis suggests that emtricitabine/tenofovir does not have a significant effect on fat redistribution or accumulation when used as pre-exposure prophylaxis in HIV negative individuals. [37] As of early 2018, these studies have not assessed in detail subtle changes in fat distribution that may be possible with the drug when used as PrEP, and statistically significant – though transient – weight changes have been attributed to detectable drug concentrations in the body. [38]

Other potential serious side effects of Truvada include acute exacerbations of hepatitis B in individuals with HBV infection, lactic acidosis, and severe hepatomegaly with steatosis. [23]

Descovy research and data from public use has shown similar "start-up" effects; however, some data indicate that Descovy is better for one's kidneys and for those with a diagnosis of osteoporosis. [39] The DISCOVER trial that compared descovy versus truvada for PrEP showed that descovy produced safer kidney and bone outcomes. [40]

The injectable form of PrEP, Cabotegravir, shares similar side effects to oral PrEP such as nausea and headache. However, one of the most common side effect is pain at injection site. [21]

Boxed warnings

Both Truvada and Descovy carry a black box warning for the combination of emtricitabine/tenofovir, as this combination of drugs can result in the acute worsening of hepatitis B infection when discontinued. This combination of drugs is also known to increase HIV resistance to these medications when used as pre-exposure prophylaxis (PrEP) in individuals who have already (recently) been infected with HIV. Cabotegravir (Apretude) shares a similar black box warning to only use the medication if a person tests negative for HIV infection. It is recommended that individuals continue to periodically get tested to determine their HIV status to ensure proper continuing use of these medications for PrEP. [23] [24]

Society and culture

Access and adoption

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Approval for use

Truvada was previously only approved by the U.S. Food and Drug Administration (FDA) to treat HIV in those already infected. In 2012, the FDA approved the drug for use as pre-exposure prophylaxis (PrEP), based on growing evidence that the drug was safe and effective at preventing HIV in populations at increased risk of infection. [41] The FDA has approved two additional medications for PrEP since then, approving Descovy in 2019 and Cabotegravir (Apretude) in 2021. [4] [5] [2]

In 2012, the World Health Organization (WHO) issued guidelines for PrEP and made similar recommendations for its use among men and transgender women who have sex with men. The WHO noted that "international scientific consensus is emerging that antiretroviral drugs, including PrEP, significantly reduce the risk of sexual acquisition and transmission of HIV regardless of population or setting." [42] : 8, 10, 11  In 2014, on the basis of further evidence, the WHO updated the recommendation for men who have sex with men to state that PrEP "is recommended as an additional HIV prevention choice within a comprehensive HIV prevention package." [43] : 4  In November 2015 the WHO expanded this further, on the basis of further evidence, and stated that it had "broadened the recommendation to include all population groups at substantial risk of HIV infection" and emphasized that PrEP should be "an additional prevention choice in a comprehensive package of services." [44]

As of 2018, numerous countries have approved the use of PrEP for HIV/AIDS prevention, including the United States, South Korea, [45] France, Norway, [46] Australia, [47] Israel, [48] Canada, [48] Kenya, South Africa, Peru, Thailand, the European Union [49] [50] , United Kingdom and Taiwan. [51]

New Zealand was one of the first countries in the world to publicly fund PrEP for the prevention of HIV in March 2018. Funded access to PrEP will require that people undergo regular testing for HIV and other sexually transmitted infections, and are monitored for risk of side effects. People taking funded PrEP will receive advice on ways to reduce the risk of HIV and sexually transmitted infections. [52]

In Australia, the country's Therapeutic Goods Administration approved the use of Truvada as PrEP in May 2016, allowing Australian providers to legally prescribe the medication. On March 21, 2018, the Federal Minister for Health announced that PrEP will be subsidized by the Australian Government through the Pharmaceutical Benefits Scheme (PBS) from April 1, 2018. [53] The Laurus Labs branded version is also available on PBS from October 2024. [54]

Availability and pricing in the United States

A bottle of 200 mg/25 mg emtricitabine and tenofovir alafenamide used for PrEP under the brand Descovy, developed by Gilead Sciences. Bottle of Descovy.jpg
A bottle of 200 mg/25 mg emtricitabine and tenofovir alafenamide used for PrEP under the brand Descovy, developed by Gilead Sciences.

Within the United States, Truvada and Descovy are brand name products of Gilead Sciences that cost around $2200/month (a 30-day supply) at wholesale price. [55] [56] In other countries around the world, generic Truvada is available for a much lower price. Expected fall of 2020, Teva Pharmaceuticals will begin producing a generic version of Truvada within the United States; however, it has been reported that the details surrounding the rights to the patent are unclear, which makes it difficult to predict if this will increase access to the medications. [57] [58] In the meantime, there are several assistance programs at the local, state, and national level for gaining access to PrEP at reduced costs. [55] Gilead has an "advancing access" co-pay coupon program that can be accessed by individuals and providers alike to help cover some of the monthly costs of these medications. [59]

In December 2019, the U.S. announced the Ready, Set, PrEP program to provide free PrEP to the uninsured through major drugstore chains. [60] The Ready, Set, PrEP program is led by the U.S. Department of Health and Human Services (HHS) and allows qualifying individuals to fill their prescription for PrEP medication free of cost at their choice of participating pharmacies or through the mail. [61]

NPIN PrEP Provider Data and Locator Widget was launched on the CDC website to provide a comprehensive, national directory of public and private providers in the U.S. that offer pre-exposure prophylaxis (PrEP) to prevent HIV infection. The database includes over 1,800 PrEP providers from all 50 U.S. states as well as U.S. territories. [62]

Beginning in January 2020, after California Governor Gavin Newsom signed Senate Bill 159 (SB159) in 2019, licensed pharmacists in California are authorized to initiate and dispense a 30 to 60 day supply of pre-exposure prophylaxis (PrEP) or the full course of post-exposure prophylaxis (PEP) without a doctor's prescription, given certain clinical criteria of the individual are met. The bill acts as an extension of Medi-Cal benefits (the Medicaid program in the state of California). [63] The law is recognized by pharmacist organizations, health providers, legislators, and the general public to be the removal of a barrier to direct and time-dependent access to these medications, especially for those in communities most affected by HIV/AIDs. [64]

Politics and culture

Since the FDA approval of PrEP for the prevention of HIV, moves toward greater adoption of PrEP have been met some issues, especially around the overall public health effect of widespread adoption, the cost of PrEP and associated disparities in availability and access. Many public health organizations and governments have embraced PrEP as a part of their overall strategy for reducing HIV. For example, in 2014 New York state governor Andrew Cuomo initiated a three-part plan to reduce HIV across New York that specifically emphasized access to PrEP. [65] Similarly, the city of San Francisco launched a "Getting to Zero" campaign. The campaign aims to dramatically reduce the number of new HIV infections in the city and relies on expanding access to PrEP as a key strategy for achieving that goal. [66] Public health officials report that since 2013 the number of new HIV infections in San Francisco has decreased almost 50% and that such improvements are likely related to the city's campaign to reduce new infections. [67] Additionally, numerous public health campaigns have been launched to educate the public about PrEP. For instance, in New York City in 2016 Gay Men's Health Crisis launched an ad campaign in bus shelters across the city reminding riders that adherence to PrEP is important to ensuring the regimen is maximally effective. [68] In Washington, D.C., a PrEP campaign was launched to increase the number of D.C. residents taking PrEP. Social media pushes, such as an ad campaign called "PrEP for Her", targeted African-American women, who, along with gay and bisexual African-American men, are at high risk of infection in the district. [69] Other states and cities that have initiated "Getting to Zero" campaigns include Massachusetts, Connecticut, Illinois, San Diego, Silicon Valley/Santa Clara, and Miami-Dade. [70] [71] [72] [73] [74] In the UK the campaign Prepster has targeted young people of color [75]

Despite those efforts, PrEP remains controversial among some who worry that widespread PrEP adoption could cause public health issues by enabling risky sexual behaviors. [76] [77] [78] For instance, AIDS Healthcare Foundation founder and director Michael Weinstein has been vocal in his opposition to PrEP adoption, suggesting that PrEP causes people to make riskier decisions about sex than they would otherwise make. [79] New research, however, indicates that there is no change in STI rates following PrEP implementation. [80] [81] Other critics point out that despite implementation of PrEP, significant disparities exist. For example, some point out that African Americans bear a disproportionate burden of HIV infections but may be less likely than whites to access PrEP. [82] Still other critics of PrEP object to the high cost of the regimen. For example, the U.K.'s NHS initially refused to offer PrEP to individuals citing concerns about cost and suggested that local officials ought to bear the responsibility of paying for the drug. However, following significant advocacy efforts, the NHS started to offer PrEP to people in the UK in 2017. [83]

Impact on the culture of men who have sex with men

PrEP is used predominantly by men who have sex with men, often as an alternative to condoms to allow otherwise unprotected "bareback" sex. For the first time since the outbreak of the AIDS crisis, PrEP makes somewhat HIV-protected sex without condoms possible, and since its availability, sex without condoms has increased. [84] PrEP does not prevent the transmission of sexually transmitted infections other than HIV, and is not 100% effective. [85]

Barriers to use

Recent systematic reviews have investigated barriers to PrEP. On a structural level, findings indicate cost of PrEP, having multiple healthcare providers, and the frequency of follow-ups play a role. [86] Other barriers include stigma and stereotyping from family, friends and providers. [86] A systematic review found that awareness of PrEP is low, but individuals were receptive to use when presented with information. [87] Common barriers to PrEP use include lack of communication between an individual and their doctor, stigmatization, concerns about safety, side effects, and cost and effectiveness. [88] [87] A possible explanation for low PrEP recommendations from physicians is the "Purview Paradox." This refers to HIV specialists believing primary care providers should be responsible for recommending and prescribing PrEP to patients. [89] However, primary care providers believe this is out of their scope of practice and PrEP use should be managed by HIV specialists. [89]

Within the MSM community, the greatest barrier to PrEP use has been the stigma surrounding HIV and gay men. Gay men on PrEP have experienced "slut-shaming". [90] [91] Numerous other barriers were identified, including lack of quality LGBTQ care, cost, and adherence to medication use. [89]

Transgender women are disproportionally affected by HIV/AIDS, [92] and PrEP is often underused. Similar to the MSM community, stigma surrounding HIV posed as a barrier for PrEP use, along with low awareness, social support and tailored communication of PreP usage for transgender people. [92] Additional barriers transgender women face include concerns about side effects, hormone therapy, adherence, and interaction with healthcare workers. [93]

Challenges encountered by people engaging in injection drug use include limited access to healthcare providers, expense of medication, and follow-up for HIV testing. [89]

Cisgender women believe they are at low risk for HIV transmission even though they meet eligibility requirements for PrEP. [94] Low marketing for women, potential stigma from support system and lack of knowledge about PrEP posed as a barrier. [95] [94]

For more information regarding barriers to healthcare access within the LGBTQIA+ community, see Healthcare and the LGBT community.

Research studies

Initial studies of PrEP strategies in non-human primates showed a reduced risk of infection among animals that receive ARVs prior to exposure to a simian form of HIV.[ medical citation needed ] A 2007 study at UT-Southwestern (Dallas) and the University of Minnesota showed PrEP to be effective in "humanized" laboratory mice. [96] In 2008, the iPrEx study demonstrated 42% reduction of HIV infection among men who have sex with men, [97] and subsequent analysis of the data has suggested that 99% protection is achievable if the drugs are taken every day. [98] Below is a table summarizing some of the major research studies that demonstrated PrEP with Truvada to be effective across different populations.[ citation needed ]

PrEP approaches with agents besides Truvada are being investigated. On December 20, 2021, the FDA approved Cabotegravir (Apretude), which was the first injectable drug for PrEP that is taken every two months. [5] There has been some evidence that other regimens, like ones based on the antiretroviral agent Maraviroc, could potentially prevent HIV infection. [99] Similarly, researchers are investigating whether drugs could be used in ways other than a daily pill to prevent HIV, including PrEP-releasing implants or rectally administered PrEP. [100]

Data on efficacy and safety of PrEP in adolescents are insufficient. Risks and benefits of PrEP use should be considered for adolescents. [11]

StudyTypeType of PrEPStudy PopulationEfficacyPercent of patients who took medication (adherence)
CAPRISA 004 Double-blind, randomizedPericoital tenofovir gelSouth African females39% reduction of HIV infection [101] 72% by applicator count [102]
iPrEx Oral emtricitabine/tenofovirMen who have sex with men and transgender women42% reduction of HIV infection. [97] 99% reduction estimated with daily adherence [98] 54% detectable in blood [103]
Partners PrEPOral emtricitabine/tenofovir; oral tenofovirAfrican heterosexual couplesReduction of infection by 73% with Truvada and 62% with tenofovir [104] 80% with Truvada and 83% with tenofovir [105] detectable in blood
TDF2Oral emtricitabine/tenofovirBotswana heterosexual couples63% reduction of infection [25] 84% by pill count [106]
FEM-PrEPOral emtricitabine/tenofovirAfrican heterosexual femalesNo reduction (study halted due to low adherence)<30% with detectable levels in blood [107]
VOICE 003 Oral emtricitabine/tenofovir; oral tenofovir; vaginal tenofovir gelAfrican heterosexual femalesNo reduction in oral tenofovir or vaginal gel arms [oral emtricitabine/tenofovir arm ongoing] [25] <30% with detectable levels in blood [108]
Bangkok Tenofovir StudyRandomized, double-blindOral tenofovirThai male injection drug users48.9% reduction of infection [109] 84% by directly observed therapy and study diaries [110]
IPERGAYRandomized, double-blindOral emtricitabine/tenofovirFrench and Quebecois gay males86% reduction of infection [18] [111] (video summary Archived 11 July 2021 at the Wayback Machine )86% with detectable levels in blood [18]
PROUDRandomized, open-labelOral tenofovir-emtricitabineHigh-risk men who have sex with men in England86% reduction of HIV incidence [112]
HPTN 083 Randomized, double-blind Cabotegravir versus emtricitabine/tenofovirTransgender women and cisgender men who have sex with men in Argentina, Brazil, Peru, Thailand, the U.S., Vietnam, and South Africa.Highly efficacious compared to daily oral TDF/FTC. [113]
Discover studyRandomized, double-blindoral TDF/FTC versus TAF/FTCHigh-risk men who have sex with men in Europe, North and South AmericaTAF/FTC was non-inferior with more favorable bone and kidney outcomes [114]

Possibility of increased risk-taking

While PrEP appears to be extremely successful in reducing HIV infection, there is mixed evidence that there might be a change in use of condoms in anal sex, [115] raising risks of spreading sexually transmitted infections other than HIV. In a meta-analysis, researchers found no significant increase in risk for STIs following starting PrEP. [81] The same systematic review found there to be no change in amount of sexual partners or condom use while using PrEP. [81] In addition, PrEP be an opportunity for MSM to access sexual health care, testing, treatment and counseling services. [116]

Emerging treatments

Although HIV PrEP medications are only available in oral tablet and injectable formulations, other formulations are being developed and studied. The emerging treatments expand HIV prevention strategies for women. For example, a vaginal gel formulation of tenofovir and an intravaginal ring releasing dapivirine are under investigation for efficacy. [17] Out of three completed trials evaluating safety and efficacy of tenofovir vaginal gel, only the CAPRISA 004 trial showed the drug to be efficacious in decreasing the risk of HIV infection. However, the demonstrated effectiveness of tenofovir vaginal gel was deemed not significant enough to move forward with the product. In contrast, the ASPIRE study and The Ring Study evaluating the dapivirine-releasing intravaginal ring have demonstrated efficacy in reducing incidence of HIV infection. In addition to these two treatments, an injectable form of cabotegravir is being evaluated for efficacy in the HPTN 03 and HPTN 04 trials. [22]

At the 2024 International AIDS Conference, PrEP with long-acting injectable cabotegravir (CAB-LA; Apretude) appears safe during pregnancy among cisgender women, according to an analysis from the HPTN 084 open-label extension trial. [117] Researchers observed composite poor pregnancy outcomes in 33% of pregnancies with active CAB-LA use, 38% with prior CAB-LA use, and 27% with no CAB-LA use. [118]

See also

Related Research Articles

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Safe sex is sexual activity using methods or contraceptive devices to reduce the risk of transmitting or acquiring sexually transmitted infections (STIs), especially HIV. "Safe sex" is also sometimes referred to as safer sex or protected sex to indicate that some safe sex practices do not eliminate STI risks. It is also sometimes used colloquially to describe methods aimed at preventing pregnancy that may or may not also lower STI risks.

<span class="mw-page-title-main">Microbicides for sexually transmitted infections</span> Pharmacologic agents and chemical substances

Microbicides for sexually transmitted infections are pharmacologic agents and chemical substances that are capable of killing or destroying certain microorganisms that commonly cause sexually transmitted infection.

<span class="mw-page-title-main">Men who have sex with men</span> Behavioral category

Men who have sex with men (MSM) are men who engage in sexual activity with other men, regardless of their sexual orientation or sexual identity. The term was created by epidemiologists in the 1990s, to better study and communicate the spread of sexually transmitted infections such as HIV/AIDS between all sexually active males, not strictly those identifying as gay, bisexual, pansexual or various other sexualities, but also for example male prostitutes. The term is often used in medical literature and social research to describe such men as a group. It does not describe any specific kind of sexual activity, and which activities are covered by the term depends on context. The alternative term "males who have sex with males" is sometimes considered more accurate in cases where those described may not be legal adults.

Post-exposure prophylaxis, also known as post-exposure prevention (PEP), is any preventive medical treatment started after exposure to a pathogen in order to prevent the infection from occurring.

<span class="mw-page-title-main">Tenofovir disoproxil</span> Antiviral drug used to treat or prevent HIV and hepatitis infections

Tenofovir disoproxil, sold under the brand name Viread among others, is a medication used to treat chronic hepatitis B and to prevent and treat HIV/AIDS. It is generally recommended for use with other antiretrovirals. It may be used for prevention of HIV/AIDS among those at high risk before exposure, and after a needlestick injury or other potential exposure. It is sold both by itself and together in combinations such as emtricitabine/tenofovir, efavirenz/emtricitabine/tenofovir, and elvitegravir/cobicistat/emtricitabine/tenofovir. It does not cure HIV/AIDS or hepatitis B. It is available by mouth as a tablet or powder.

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Emtricitabine/tenofovir, sold under the brand name Truvada among others, is a fixed-dose combination antiretroviral medication used to treat and prevent HIV/AIDS. It contains the antiretroviral medications emtricitabine and tenofovir disoproxil. For treatment, it must be used in combination with other antiretroviral medications. For prevention before exposure, in those who are at high risk, it is recommended along with safer sex practices. It does not cure HIV/AIDS. Emtricitabine/tenofovir is taken by mouth.

<span class="mw-page-title-main">HIV Prevention Trials Network</span>

The HIV Prevention Trials Network (HPTN) is a worldwide collaborative clinical trials network that brings together investigators, ethicists, community and other partners to develop and test the safety and efficacy of interventions designed to prevent the acquisition and transmission of HIV. HPTN studies evaluate new HIV prevention interventions and strategies in populations and geographical regions that bear a disproportionate burden of infection. The HPTN is committed to the highest ethical standards for its clinical trials and recognizes the importance of community engagement in all phases of the research process.

The history of HIV/AIDS in Australia is distinctive, as Australian government bodies recognised and responded to the AIDS pandemic relatively swiftly, with the implementation of effective disease prevention and public health programs, such as needle and syringe programs (NSPs). As a result, despite significant numbers of at-risk group members contracting the virus in the early period following its discovery, Australia achieved and has maintained a low rate of HIV infection in comparison to the rest of the world.

iPrEx

iPrEx was a phase III clinical trial to determine whether the antiretroviral medication emtricitabine/tenofovir could safely and effectively prevent HIV acquisition through sex in men who have sex with men and transgender women. iPrEx was the first human study of an HIV prevention strategy known as pre-exposure prophylaxis, or PrEP.

HIV prevention refers to practices that aim to prevent the spread of the human immunodeficiency virus (HIV). HIV prevention practices may be undertaken by individuals to protect their own health and the health of those in their community, or may be instituted by governments and community-based organizations as public health policies.

<span class="mw-page-title-main">Tenofovir alafenamide</span> Chemical compound

Tenofovir alafenamide, sold under the brand name Vemlidy, is an antiviral medication used against hepatitis B and HIV. It is used for the treatment of chronic hepatitis B virus (HBV) infection in adults with compensated liver disease and is given in combination with other medications for the prevention and treatment of HIV. It is taken by mouth.

A rectal microbicide is a microbicide for rectal use. Most commonly such a product would be a topical gel inserted into the anus so that it make act as protection against the contract of a sexually transmitted infection during anal sex.

<span class="mw-page-title-main">Cabotegravir</span> Medication for HIV/AIDS

Cabotegravir, sold under the brand name Vocabria among others, is a antiretroviral medication used for the treatment of HIV/AIDS. It is available in the form of tablets and as an intramuscular injection, as well as in an injectable combination with rilpivirine under the brand name Cabenuva.

<span class="mw-page-title-main">Elioda Tumwesigye</span> Ugandan politician

Elioda Tumwesigye is a Ugandan politician, physician, and epidemiologist who has served as minister of science, technology and innovation in the cabinet of Uganda since June 2016. From March 2015 until June 2016, he served as the minister of health.

National AIDS Trust v NHS Commissioning Board, [2016] EWHC 2005 (Admin), was a court case before the High Court of Justice seeking judicial review regarding National Health Service funding for pre-exposure prophylaxis.

HPTN 083 is a 2016 clinical trial which compares cabotegravir injections with oral use of Emtricitabine/tenofovir as pre-exposure prophylaxis ("PrEP") for prevention of HIV/AIDS.

Margaret Denise Portman was a British medical doctor who specialised in sexual health. She was an advocate for pre-exposure prophylaxis medication (PrEP) to prevent new HIV cases.

In January 2018, the provincial government of British Columbia (BC) began providing individuals at high risk of HIV infection with pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) at no cost. High risk individuals include men and trans women who have sex with men, people who inject drugs, and people who have sex with people living with HIV. One year following this policy change, which is delivered as part of the British Columbia Centre for Excellence in HIV/AIDS (BC-CfE)'s Drug Treatment Program, almost 3,300 people have been prescribed with PrEP or PEP.

<span class="mw-page-title-main">Lenacapavir</span> Antiretroviral medication

Lenacapavir, sold under the brand name Sunlenca, is an antiretroviral medication used to treat HIV/AIDS. It is taken by mouth or by subcutaneous injection.

Pre-exposure prophylaxis (PrEP), is the use of medications to prevent the spread of disease in people who have not yet been exposed to a disease-causing agent. Vaccination is the most commonly used form of pre-exposure prophylaxis; other forms of pre-exposure prophylaxis generally involve drug treatment, known as chemoprophylaxis. Examples include taking medication to prevent infection by malaria or HIV. In particular, the term PrEP is now synonymous in popular usage with the use of pre-exposure prophylaxis for HIV prevention.

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