Peter Duesberg

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Peter H. Duesberg
Peter Duesberg at a cancer meeting in Berkeley in 2017.jpg
Berkeley cancer meeting, 2017
Born (1936-12-02) December 2, 1936 (age 87)
Münster, Germany
Alma mater University of Frankfurt
Known for Oncogene research
AIDS denialism
Scientific career
FieldsCancer
Institutions University of California, Berkeley
Thesis Fraktionierungen von Proteinen – besonders Enzymen – mit Ionenaustauschern und Molekularsieben <vom Typ Sephadex>  (1963)

Peter H. Duesberg (born December 2, 1936) is a German-American molecular biologist and a professor of molecular and cell biology at the University of California, Berkeley. He is known for his early research into the genetic aspects of cancer. He is a proponent of AIDS denialism, the claim that HIV does not cause AIDS.

Contents

Duesberg received acclaim early in his career for research on oncogenes and cancer. With Peter K. Vogt, he reported in 1970 that a cancer-causing virus of birds had extra genetic material compared with non-cancer-causing viruses, hypothesizing that this material contributed to cancer. [1] [2] At the age of 36, Duesberg was awarded tenure at the University of California, Berkeley, and at 49, he was elected to the National Academy of Sciences. He received an Outstanding Investigator Grant from the National Institutes of Health in 1986, [3] and from 1986 to 1987 was a Fogarty scholar-in-residence at the NIH laboratories in Bethesda, Maryland.

Long considered a contrarian by his scientific colleagues, [4] Duesberg began to gain public notoriety with a March 1987 article in Cancer Research entitled "Retroviruses as Carcinogens and Pathogens: Expectations and Reality". [5] In this and subsequent writings, Duesberg proposed his hypothesis that AIDS is caused by long-term consumption of recreational drugs or antiretroviral drugs, and that the retrovirus known as 'HIV' is a harmless passenger virus. In contrast, the scientific consensus is that HIV infection causes AIDS; [6] Duesberg's HIV/AIDS claims have been addressed and rejected as erroneous by the scientific community. [7] [8] [9] Reviews of his opinions in Nature [10] and Science [11] asserted that they were unpersuasive and based on selective reading of the literature, and that although Duesberg had a right to a dissenting opinion, his failure to fairly review evidence that HIV causes AIDS meant that his opinion lacked credibility. [11] [12]

Duesberg's views are cited as major influences on South African HIV/AIDS policy under the administration of Thabo Mbeki, which embraced AIDS denialism. Duesberg served on an advisory panel to Mbeki convened in 2000. The Mbeki administration's failure to provide antiretroviral drugs in a timely manner, due in part to the influence of AIDS denialism, is thought to be responsible for hundreds of thousands of preventable AIDS deaths and HIV infections in South Africa. [13] [14] Duesberg disputed these findings in an article in the journal Medical Hypotheses , [15] but the journal's publisher, Elsevier, later retracted Duesberg's article over accuracy and ethics concerns as well as its rejection during peer review. [16] [17] The incident prompted several complaints to Duesberg's institution, the University of California, Berkeley, which began a misconduct investigation of Duesberg in 2009. [18] [19] The investigation was dropped in 2010, with university officials finding "insufficient evidence ... to support a recommendation for disciplinary action." [20] [21]

In 2021, Peter Duesberg had a stroke that left him with severe aphasia affecting speech, reading and writing, according to his partner. [22]

Early life

Duesberg grew up during World War II, raised as a Catholic in Germany. [23] He moved to the US in 1964 to work at the University of California, Berkeley, following completion of a Ph.D. in chemistry at the University of Frankfurt. [23]

Work

Cancer

In the 1970s, Duesberg won international acclaim for his groundbreaking work on cancer. [24] Duesberg's early work on cancer included being the first to identify the oncogene v-src from the genome of Rous sarcoma virus, a chicken virus believed to trigger tumor growth. [23] Duesberg disputes the importance of oncogenes and retroviruses in cancer. He supports the aneuploidy hypothesis of cancer that was first proposed in 1914 by Theodor Heinrich Boveri. [23] [25]

Duesberg rejects the importance of mutations, oncogenes, and anti-oncogenes entirely. Duesberg along with other researchers, in a 1998 paper published in Proceedings of the National Academy of Sciences , reported a mathematical correlation between chromosome number and the genetic instability of cancer cells, which they dubbed "the ploidy factor," [26] confirming earlier research by other groups [27] that demonstrated an association between degree of aneuploidy and metastasis.

Although unwilling to concur with Duesberg in throwing out a role for cancer genes, many researchers do support exploration of alternative hypotheses. [28] Research and debate on this subject is ongoing. In 2007, Scientific American published an article by Duesberg on his aneuploidy cancer theory. [29] In an editorial explaining their decision to publish this article, the editors of Scientific American stated: "Thus, as wrong as Duesberg surely is about HIV, there is at least a chance that he is significantly right about cancer." [30]

A consequence of Duesberg's aneuploidy theory of cancer is his opposition to Human Papilloma Virus (HPV) vaccination, [31] as Duesberg has challenged the causal relation between past HPV infection and the eventual development of cervical cancer. [32] Although Duesberg generally favors vaccination, he vehemently opposed the rollout of the HPV vaccine stating it was all risk and no benefit. [33]

AIDS

In his 1996 book, Inventing the AIDS Virus , published by Regnery Publishing, a politically conservative book publisher based in Washington, D.C., and in numerous journal articles and letters to the editor, Duesberg asserts that HIV is harmless and that recreational and pharmaceutical drug use, especially of zidovudine (AZT, a drug used in the treatment of AIDS) are the causes of AIDS outside Africa (the so-called Duesberg hypothesis). He considers AIDS diseases as markers for drug use, e.g., use of poppers (alkyl nitrites) among some homosexuals, asserting a correlation between AIDS and recreational drug use. [34] This correlation hypothesis has been disproven by evidence showing that only HIV infection, not homosexuality or recreational/pharmaceutical drug use, predicts who will develop AIDS. [6] [8] [35] [36] [37]

Duesberg asserts that AIDS in Africa is misdiagnosed and the epidemic a "myth", claiming incorrectly [38] that the diagnostic criteria for AIDS are different in Africa than elsewhere., [39] [40] and that the breakdown of the immune system in African AIDS patients can be explained exclusively by factors such as malnutrition, tainted drinking water, and various infections that he presumes are common to AIDS patients in Africa. [40] Duesberg also argues that retroviruses like HIV must be harmless to survive, and that the normal mode of retroviral propagation is mother-to-child transmission by infection in utero. [41]

Since Duesberg published his first paper on the subject in 1987, scientists have examined and criticized the accuracy of his hypotheses on AIDS causation. Duesberg entered a long dispute with John Maddox, then-editor of the scientific journal Nature , demanding the right to rebut articles that HIV caused AIDS. For several years Maddox consented to this demand [10] but ultimately refused to continue to publish Duesberg's criticisms:

[Duesberg] forfeited the right to expect answers by his rhetorical technique. Questions left unanswered for more than about ten minutes he takes as further proof that HIV is not the cause of AIDS. Evidence that contradicts his alternative drug hypothesis is on the other hand brushed aside...Duesberg will not be alone in protesting that this is merely a recipe for suppressing challenges to received wisdom. So it can be. But Nature will not so use it. Instead, what Duesberg continues to say about the causation of AIDS will be reported in the general interest. When he offers a text for publication that can be authenticated, it will if possible be published.

Maddox, 1993 [12]

A number of scientific criticisms of Duesberg's hypothesis were summarized in a review article in the journal Science in 1994, which presented the results of a 3-month scientific investigation into some of Duesberg's claims. In the Science article, science writer Jon Cohen interviewed both HIV researchers and AIDS denialists (including Duesberg himself) and examined the AIDS literature in addition to review articles written by Duesberg. The article stated:

...although the Berkeley virologist raises provocative questions, few researchers find his basic contention that HIV is not the cause of AIDS persuasive. Mainstream AIDS researchers argue that Duesberg's arguments are constructed by a selective reading of the scientific literature, dismissing evidence that contradicts his theses, requiring impossibly definitive proof, and dismissing outright studies marked by inconsequential weaknesses.

Jon Cohen. [11]

The article also stated that Duesberg and the AIDS denialist movement have garnered support from some prominent scientists, including Nobel Prize winner Kary Mullis, while others are cited as "equally, if not more, concerned about the treatment Duesberg has received at the hands of the establishment", rather than support of his specific claim that HIV does not cause AIDS. [11] Duesberg has been described as "the individual who has done the most damage" regarding denialism, due to the apparent scientific legitimacy his scientific credentials give to his statements. [7]

In a 2010 article on conspiracy theories in science, Ted Goertzel highlights Duesberg's opposition to the HIV/AIDS connection as an example in which scientific findings are disputed on irrational grounds, relying on rhetoric, appeal to fairness and the right to a dissenting opinion rather than on evidence. Goertzel stated that Duesberg, along with many other denialists frequently invoke the meme of a "courageous independent scientist resisting orthodoxy", invoking the name of persecuted physicist and astronomer Galileo Galilei. [10] Regarding this comparison, Goertzel stated:

...being a dissenter from orthodoxy is not difficult; the hard part is actually having a better theory. Publishing dissenting theories is important when they are backed by plausible evidence, but this does not mean giving critics 'equal time' to dissent from every finding by a mainstream scientist.

Goertzel, 2010 [10]

Duesberg's advocacy of AIDS denialism has, by all accounts, effectively made him a pariah to the worldwide scientific community. [4]

Consequences of AIDS denialism

In 2000, Duesberg was the most prominent AIDS denialist to sit on a 44-member Presidential Advisory Panel on HIV and AIDS convened by then-president Thabo Mbeki of South Africa. [42] The panel was scheduled to meet concurrently with the 2000 International AIDS Conference in Durban and to convey the impression that Mbeki's doubts about HIV/AIDS science were valid and actively discussed in the scientific community. [14]

The views of the denialists on the panel, aired during the AIDS conference, received renewed attention. [43] Mbeki later suffered substantial political fallout for his support for AIDS denialism [44] [45] and for opposing the treatment of pregnant HIV-positive South African women with antiretroviral medication. [46] Mbeki partly attenuated his ties with denialists in 2002, asking them to stop associating their names with his. [47]

In response to the inclusion of AIDS denialists on Mbeki's panel, the Durban Declaration was drafted and signed by over 5,000 scientists and physicians, describing the evidence that HIV causes AIDS as "clear-cut, exhaustive and unambiguous". [48]

Two independent studies have concluded that the public health policies of Thabo Mbeki's government, shaped in part by Duesberg's writings and advice, were responsible for over 330,000 excess AIDS deaths and many preventable infections, including those of infants. [13] [14]

A 2008 feature story on Duesberg in Discover addresses Duesberg's role in anti-HIV drug-preventable deaths in South Africa. Jeanne Lenzer interviews prominent HIV/AIDS expert Max Essex, who suggests that,

...history will judge Duesberg as either "a nut who is just a tease to the scientific community" or an "enabler to mass murder" for the deaths of many AIDS patients in Africa. [4]

Academic misconduct investigation

In 2009, Duesberg and co-authors including David Rasnick published an article in Medical Hypotheses , an unconventionally peer reviewed journal. The article, HIV-AIDS hypothesis out of touch with South African AIDS – A new perspective, had been rejected previously by the journal JAIDS , and a peer reviewer had warned that the authors could face scientific misconduct charges if the paper were published.

The reviewers claimed that Duesberg and his co-authors cherry-picked data, cited favorable results while ignoring unfavorable results, and quoted statements out of context. The article was not revised in response to these criticisms. Moreover, the reviewers claim that Duesberg, though he included in the article that neither he nor his co-authors had financial conflicts of interest, "[committed] a serious breach of professional ethics" by failing to state a possible conflict of interest: That co-author Rasnick previously worked for Matthias Rath, a vitamin entrepreneur who sold vitamin pills as AIDS remedies. [19]

In the article, Duesberg questioned research reporting that drug policies implemented by the South African government on the advice of Duesberg, Rasnick and others had led to excess AIDS deaths. [15] Observing that the overall population of South Africa has increased, Duesberg claimed that HIV must be a harmless "passenger virus" that has not caused deaths in South Africa or elsewhere. Duesberg stated that HIV does not replicate in the body and that antiviral drugs, which he calls "inevitably toxic," do not inhibit HIV. [15]

Scientists expressed concerns to Elsevier, the publisher of Medical Hypotheses, about unsupported assertions and incorrect statements by Duesberg. After an internal review and with a unanimous recommendation of rejection by five Lancet reviewers, Elsevier stated that the article was flawed and of potential danger to global public health. [15] Elsevier permanently withdrew [49] the Duesberg article and another AIDS denialist publication and asked that the editor of the journal implement a conventional peer review process. [16] [17] [50]

Letters of complaint to the University of California, Berkeley, including one from Nathan Geffen of the South African Treatment Action Campaign (TAC), prompted university officials to open an inquiry into possible academic misconduct related to false statements and failure to disclose potential conflicts of interest. [18] [19] The investigation was dropped in 2010, with university officials finding "insufficient evidence...to support a recommendation for disciplinary action." The investigation did not evaluate the merits of the research but found that publishing the article was protected by the principle of academic freedom. [20]

Related Research Articles

The Duesberg hypothesis is the claim that AIDS is not caused by HIV, but instead that AIDS is caused by noninfectious factors such as recreational and pharmaceutical drug use and that HIV is merely a harmless passenger virus. The hypothesis was popularized by Peter Duesberg, a professor of biology at University of California, Berkeley, from whom the hypothesis gets its name. The scientific consensus is that the Duesberg hypothesis is incorrect and that HIV is the cause of AIDS. The most prominent supporters of the hypothesis are Duesberg himself, biochemist and vitamin proponent David Rasnick, and journalist Celia Farber. The scientific community generally contends that Duesberg's arguments in favor of the hypothesis are the result of cherry-picking predominantly outdated scientific data and selectively ignoring evidence that demonstrates HIV's role in causing AIDS.

Various fringe theories have arisen to speculate about purported alternative origins for the human immunodeficiency virus (HIV) and the acquired immunodeficiency syndrome (AIDS), with claims ranging from it being due to accidental exposure to supposedly purposeful acts. Several inquiries and investigations have been carried out as a result, and each of these theories has consequently been determined to be based on unfounded and/or false information. HIV has been shown to have evolved from or be closely related to the simian immunodeficiency virus (SIV) in West Central Africa sometime in the early 20th century. HIV was discovered in the 1980s by the French scientist Luc Montagnier. Before the 1980s, HIV was an unknown deadly disease.

<span class="mw-page-title-main">HIV/AIDS denialism</span> False belief that HIV does not cause AIDS

HIV/AIDS denialism is the belief, despite conclusive evidence to the contrary, that the human immunodeficiency virus (HIV) does not cause acquired immune deficiency syndrome (AIDS). Some of its proponents reject the existence of HIV, while others accept that HIV exists but argue that it is a harmless passenger virus and not the cause of AIDS. Insofar as they acknowledge AIDS as a real disease, they attribute it to some combination of sexual behavior, recreational drugs, malnutrition, poor sanitation, haemophilia, or the effects of the medications used to treat HIV infection (antiretrovirals).

The oral polio vaccine (OPV) AIDS hypothesis is a now-discredited hypothesis that the AIDS pandemic originated from live polio vaccines prepared in chimpanzee tissue cultures, accidentally contaminated with simian immunodeficiency virus and then administered to up to one million Africans between 1957 and 1960 in experimental mass vaccination campaigns.

David William Rasnick is an American biochemist known for his association with the AIDS denialist movement, which denies the fact that HIV is the cause of AIDS, and for his involvement with clinical trials in South Africa promoting vitamins for the treatment of AIDS, which were later ruled illegal by the South African judiciary.

A passenger virus is a virus that is frequently found in samples from diseased tissue, such as tumours, but is not a contributing factor in causing the disease.

Alive & Well AIDS Alternatives is a 501(c) non-profit organization of AIDS denialists. The organization's stated mission is to "present information that raises questions about the accuracy of HIV tests, the safety and effectiveness of AIDS drug treatments, and the validity of most common assumptions about HIV and AIDS." The organization's founder, Christine Maggiore estimated in 2005 that the organization had assisted about 50 HIV-positive mothers in developing legal strategies to avoid having their children tested or treated for HIV.

<span class="mw-page-title-main">Harvey Bialy</span> American molecular biologist and AIDS denialist

Harvey Bialy was an American molecular biologist and AIDS denialist. He was one of the signatories to a letter to the editor by the "Group for the Scientific Reappraisal of the HIV-AIDS Hypothesis", which denied that HIV was the cause of AIDS, and was a member of the controversial and heavily criticized South African Presidential AIDS Advisory Panel convened by Thabo Mbeki in 2000. Bialy authored a scientific biography of Peter Duesberg, a fellow AIDS denialist, in 2004.

The Durban Declaration is a statement signed by over 5,000 physicians and scientists in 2000, affirming that HIV is the cause of AIDS, seventeen years after the discovery of the Human Immunodeficiency Virus. The declaration was drafted in response to HIV/AIDS denialism, and particularly to address South African president Thabo Mbeki's support for AIDS denialists. It was written several weeks before the 2000 International AIDS Conference, held in Durban, South Africa from July 9 to 14, 2000, and was published in the journal Nature to coincide with the Durban conference. The declaration called the evidence that HIV causes AIDS "clear-cut, exhaustive and unambiguous".

Celia Ingrid Farber is an American print journalist and author who has covered a range of topics for magazines including Spin, Rolling Stone, Esquire, Harper's, Interview, Salon, Gear, New York Press, Media Post, The New York Post and Sunday Herald, and is best known for her controversial beliefs about HIV and AIDS, and a 1998 report on O. J. Simpson's post-trial life. Farber is the daughter of radio talk pioneer Barry Farber and a graduate of New York University.

<i>Medical Hypotheses</i> Unconventional academic journal (1975-)

Medical Hypotheses is a not-conventionally-peer-reviewed medical journal published by Elsevier. It was originally intended as a forum for unconventional ideas without the traditional filter of scientific peer review, "as long as are coherent and clearly expressed" in order to "foster the diversity and debate upon which the scientific process thrives." The publication of papers on AIDS denialism led to calls to remove it from PubMed, the United States National Library of Medicine online journal database. Following the AIDS papers controversy, Elsevier forced a change in the journal's leadership. In June 2010, Elsevier announced that "submitted manuscripts will be reviewed by the Editor and external reviewers to ensure their scientific merit".

<i>The Other Side of AIDS</i> 2004 American film

The Other Side of AIDS is a 2004 pseudoscience film by Robin Scovill. Through interviews with prominent AIDS denialists and HIV-positive people who have refused anti-HIV medication, the film makes the claim that HIV is not the cause of AIDS and that HIV treatments are harmful, conclusions which are rejected by medical and scientific consensus. The film was reviewed in Variety and The Hollywood Reporter in 2004, and received additional attention in 2005, when Scovill's three-year-old daughter died of untreated AIDS.

<span class="mw-page-title-main">Pride Chigwedere</span> Zimbabwean physician-scientist

Pride Chigwedere, a Zimbabwean national, is a Harvard trained physician-scientist working in global health. He is most notable for leading a team of Harvard researchers who demonstrated that South African President Thabo Mbeki's AIDS policies led to more than 300 000 deaths. While South Africa's policies were condemned by many, Chigwedere's contribution was in developing and applying methods to quantify the impact of the policies thus demonstrating the calamitous consequences of AIDS denialism. Generalized, he developed an approach for evaluating public health practice and highlighted the need to develop a framework for accountability in public health. Drawing from the analogy with medicine, he has proposed the concept of public health malpractice to capture negligence that causes harm as a useful first step towards accountability in public health. A response to Chigwedere's work by AIDS denialists led by Peter Duesberg was initially published by the non-peer-reviewed journal Medical Hypotheses followed by a retraction because of poor quality of data, undeclared conflicts of interest, and potential effects on global health.

<i>House of Numbers: Anatomy of an Epidemic</i> 2009 American film

House of Numbers: Anatomy of an Epidemic is a 2009 film directed, produced, and hosted by Brent Leung and described by him as an objective examination of the idea that HIV causes AIDS. The film argues that human immunodeficiency virus (HIV) is harmless and does not cause acquired immune deficiency syndrome (AIDS), a position known as AIDS denialism. The film's claims of impartiality have been widely rejected by scientists, and the film's claims about HIV and AIDS have been dismissed as pseudoscience and conspiracy theory masquerading as even-handed examination.

The Perth Group is a group of HIV/AIDS denialists based in Perth, Western Australia who claim, in opposition to the scientific consensus, that the existence of HIV is not proven, and that AIDS and all the "HIV" phenomena are caused by changes in cellular redox due to the oxidative nature of substances and exposures common to all the AIDS risk groups, and are caused by the cell conditions used in the "culture" and "isolation" of "HIV".

<i>Inventing the AIDS Virus</i> 1996 book by Peter Duesberg

Inventing the AIDS Virus is a 1996 book by molecular biologist Peter Duesberg, in which the author argues that HIV does not cause AIDS. Duesberg contends that HIV is a harmless passenger virus and that AIDS is caused by unrelated factors such as drug abuse, antiretroviral medication, chronic malnutrition, poor sanitation, and hemophilia. The unambiguous scientific consensus is that HIV causes AIDS and that Duesberg's claims are incorrect. Duesberg received a negative response from the scientific community for supporting AIDS denialism, misrepresenting and ignoring the scientific evidence that HIV causes AIDS, and for relying upon poor logic and manipulation. The book was also the subject of an authorship dispute with one of his graduate students.

<i>Continuum</i> (magazine) Magazine featuring AIDS denialism

Continuum was a magazine published by an activist group of the same name who denied the existence of HIV/AIDS.

In South Africa, HIV/AIDS denialism had a significant impact on public health policy from 1999 to 2008, during the presidency of Thabo Mbeki. Mbeki criticized the scientific consensus that HIV is the cause of AIDS beginning shortly after his election to the presidency. In 2000, he organized a Presidential Advisory Panel regarding HIV/AIDS including several scientists who denied that HIV caused AIDS.

Big Pharma conspiracy theories are conspiracy theories which claim that pharmaceutical companies, especially large corporations, act in sinister and secretive ways, such as concealing effective treatments, or even intentionally causing and worsening a wide range of diseases, in pursuit of profitability, or for other nefarious reasons. Some theories have included the claim that natural alternative remedies to health problems are being suppressed, the claim that drugs for the treatment of HIV/AIDS are ineffective and harmful, the claim that a cure for all cancers has been discovered but hidden from the public, claims that COVID-19 vaccines are ineffective, and that alternative cures are available for COVID-19. In most cases the conspiracy theorists have blamed pharmaceutical companies' search for profits. A range of authors have shown these claims to be false, though some of these authors nevertheless maintain that other criticisms of the pharmaceutical industry are legitimate.

John P. Moore is an American virologist and professor at Cornell University's Weill Cornell Medicine college, known for his research on HIV/AIDS. He previously worked at the Aaron Diamond AIDS Research Center. A former section editor of the Journal of General Virology, he is an outspoken critic of HIV/AIDS denialism, including the work of Peter Duesberg.

References

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Works cited

Further reading

Mainstream scientific opinion