Proto-oncogene Wnt-1

Last updated
WNT1
Identifiers
Aliases WNT1 , BMND16, INT1, OI15, Wnt family member 1
External IDs OMIM: 164820 MGI: 98953 HomoloGene: 3963 GeneCards: WNT1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005430

NM_021279

RefSeq (protein)

NP_005421

NP_067254

Location (UCSC) Chr 12: 48.98 – 48.98 Mb Chr 15: 98.69 – 98.69 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Proto-oncogene Wnt-1, or Proto-oncogene Int-1 homolog is a protein that in humans is encoded by the WNT1 ( INT1 ) gene. [5] [6]

Contents

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [7]

See also

Related Research Articles

The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the names Wingless and Int-1. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are highly evolutionarily conserved in animals, which means they are similar across animal species from fruit flies to humans.

<span class="mw-page-title-main">FGF3</span> Protein-coding gene in humans

INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene.

<span class="mw-page-title-main">Frizzled</span> Family of G-protein coupled receptor proteins

Frizzled is a family of atypical G protein-coupled receptors that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol.

<span class="mw-page-title-main">Notch 4</span> Protein-coding gene in the species Homo sapiens

Neurogenic locus notch homolog 4(Notch 4) is a protein that in humans is encoded by the NOTCH4 gene located on chromosome 6.

<span class="mw-page-title-main">Frizzled-5</span> Protein-coding gene in the species Homo sapiens

Frizzled-5(Fz-5) is a protein that in humans is encoded by the FZD5 gene.

<span class="mw-page-title-main">Frizzled-3</span> Protein-coding gene in the species Homo sapiens

Frizzled-3(Fz-3) is a protein that in humans is encoded by the FZD3 gene.

<span class="mw-page-title-main">Frizzled-1</span> Protein-coding gene in the species Homo sapiens

Frizzled-1(Fz-1) is a protein that in humans is encoded by the FZD1 gene.

<span class="mw-page-title-main">Frizzled-6</span> Protein-coding gene in the species Homo sapiens

Frizzled-6(Fz-6) is a protein that in humans is encoded by the FZD6 gene.

<span class="mw-page-title-main">Frizzled-7</span> Protein-coding gene in the species Homo sapiens

Frizzled-7(Fd-7) is a protein that in humans is encoded by the FZD7 gene.

<span class="mw-page-title-main">Frizzled-8</span> Protein-coding gene in the species Homo sapiens

Frizzled-8(Fz-8) is a protein that in humans is encoded by the FZD8 gene.

<span class="mw-page-title-main">Frizzled-9</span> Protein-coding gene in the species Homo sapiens

Frizzled-9(Fz-9) is a protein that in humans is encoded by the FZD9 gene. Fz-9 has also been designated as CD349.

<span class="mw-page-title-main">Frizzled-4</span> Protein-coding gene in the species Homo sapiens

Frizzled-4(Fz-4) is a protein that in humans is encoded by the FZD4 gene. Fz-4 has also been designated as CD344.

<span class="mw-page-title-main">Secreted frizzled-related protein 1</span> Protein-coding gene in the species Homo sapiens

Secreted frizzled-related protein 1, also known as SFRP1, is a protein which in humans is encoded by the SFRP1 gene.

<span class="mw-page-title-main">Protein Wnt-5a</span> Protein-coding gene in the species Homo sapiens

Protein Wnt-5a is a protein that in humans is encoded by the WNT5A gene.

<span class="mw-page-title-main">LRP6</span> Protein-coding gene in the species Homo sapiens

Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6 gene. LRP6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway.

<span class="mw-page-title-main">WNT3</span> Protein and coding gene in humans

Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.

<span class="mw-page-title-main">WNT10B</span> Protein-coding gene in the species Homo sapiens

Protein Wnt-10b is a protein that in humans is encoded by the WNT10B gene.

<span class="mw-page-title-main">WNT2B</span> Protein-coding gene in the species Homo sapiens

Protein Wnt-2b is a protein that in humans is encoded by the WNT2B gene.

<span class="mw-page-title-main">WNT2</span> Protein-coding gene in the species Homo sapiens

Wingless-type MMTV integration site family, member 2, also known as WNT2, is a human gene.

<span class="mw-page-title-main">RNF43</span> Protein-coding gene in the species Homo sapiens

Ring finger protein 43 is a protein that in humans is encoded by the RNF43 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000125084 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022997 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. van Ooyen A, Kwee V, Nusse R (Jan 1986). "The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences". EMBO J. 4 (11): 2905–9. doi:10.1002/j.1460-2075.1985.tb04021.x. PMC   554596 . PMID   2998762.
  6. Arheden K, Mandahl N, Strombeck B, Isaksson M, Mitelman F (May 1988). "Chromosome localization of the human oncogene INT1 to 12q13 by in situ hybridization". Cytogenet Cell Genet. 47 (1–2): 86–87. doi:10.1159/000132513. PMID   3281802.
  7. "Entrez Gene: WNT1 wingless-type MMTV integration site family, member 1".

Further reading