The Great Siege of Malta occurred in 1565 when the Ottoman Empire attempted to conquer the island of Malta, then held by the Knights Hospitaller. The siege lasted nearly four months, from 18 May to 12 September 1565.
The Battle of Djerba took place in May 1560 near the island of Djerba, Tunisia. The Ottomans under Piyale Pasha's command overwhelmed a large joint Christian Alliance fleet, composed chiefly of Spanish, Papal, Genoese, Maltese, and Neapolitan forces. The allies lost 27 galleys and some smaller vessels as well as the fortified island of Djerba. This victory marked perhaps the high point of Ottoman power in the Mediterranean Sea.
Hayreddin Barbarossa, also known as Hayreddin Pasha, Hızır Hayrettin Pasha, and simply Hızır Reis, was an Ottoman corsair and later admiral of the Ottoman Navy. Barbarossa's naval victories secured Ottoman dominance over the Mediterranean during the mid-16th century.
Fra' Juan de Homedes y Coscón was a Spanish knight of Aragon who served as the 47th Grand Master of the Order of Malta, between 1536 and 1553.
The history of Islam in Sicily and southern Italy began with the first Arab settlement in Sicily, at Mazara, which was captured in 827. The subsequent rule of Sicily and Malta started in the 10th century. The Emirate of Sicily lasted from 831 until 1061, and controlled the whole island by 902. Though Sicily was the primary Muslim stronghold in Italy, some temporary footholds, the most substantial of which was the port city of Bari, were established on the mainland peninsula, especially in mainland southern Italy, though Muslim raids, mainly those of Muhammad I ibn al-Aghlab, reached as far north as Naples, Rome and the northern region of Piedmont. The Arab raids were part of a larger struggle for power in Italy and Europe, with Christian Byzantine, Frankish, Norman and local Italian forces also competing for control. Arabs were sometimes sought as allies by various Christian factions against other factions.
Kurtoğlu Muslihiddin Reis was the admiral of the Ottoman Empire, as well as the Sanjak Bey of Rhodes. He played an important role in the Ottoman conquests of Egypt (1517) and Rhodes (1522) during which he commanded the Ottoman naval forces. He also helped establish the Ottoman Indian Ocean Fleet based in Suez, which was later commanded by his son, Kurtoğlu Hızır Reis.
Salah Rais was the 7th King of Algiers, an Ottoman privateer and admiral. He is alternatively referred to as Sala Reis, Salih Rais, Salek Rais and Cale Arraez in several European sources, particularly in Spain, France and Italy.
The conquest of Tunis occurred in 1535 when the Habsburg Emperor Charles V and his allies wrestled the city away from the control of the Ottoman Empire.
The siege of Tripoli occurred in 1551 when the Ottoman Turks and Barbary pirates besieged and vanquished the Knights of Malta in the Red Castle of Tripoli, modern Libya. The Spanish had established an outpost in Tripoli in 1510, and Charles V remitted it to the Knights in 1530. The siege culminated in a six-day bombardment and the surrender of the city on 15 August.
The capture of Mahdia was an amphibious military operation that took place from June to September, 1550, during the struggle between the Ottoman Empire and the Spanish Habsburgs for the control of the Mediterranean. A Spanish naval expedition under the command of the Genoese condottiero and admiral Andrea Doria and the Spaniard Bernardino de Mendoza, supported by the Knights of Malta under their Grand Master Claude de la Sengle, besieged and captured the Ottoman stronghold of Mahdia or Mahdiye, defended by the Ottoman Admiral Turgut Reis, known as Dragut, who was using the place as a base for his piratical activities throughout the Spanish and Italian coasts. Mahdia was abandoned by Spain three years later, and all its fortifications were demolished to avoid a re-occupation of the city by the Ottomans.
Between April and June 1563 the Regency of Algiers launched a major military campaign to retake the Spanish military-bases of Oran and Mers el Kébir on the North African coast, occupied by Spain since 1505. The sieges of Oran and Mers El Kébir of 1563 represented a major Hispano-Algerian episode in the larger Ottoman-Habsburg wars of the Mediterranean. The Kingdom of Algiers, the Principalities of Kabyle, and other vassal tribes combined forces as one army under Hasan Pasha, son of Hayreddin Barbarossa, and Jafar Catania. The Spanish commander brothers, Alonso de Córdoba Count of Alcaudete and Martín de Córdoba, managed to hold the strongholds of Oran and Mers El Kébir, respectively, until the relief fleet of Francisco de Mendoza arrived to successfully defeat the offensive.
The Invasion of Gozo took place in July 1551, and was accomplished by the Ottoman Empire against the island of Gozo, following an unsuccessful attempt to conquer nearby Malta on 18 July 1551. It was followed by a victorious campaign with the siege of Tripoli.
Dragut, also known as "the Drawn Sword of Islam", was an Ottoman corsair, naval commander, governor, and noble. Under his command, the Ottoman Empire's maritime power was extended across North Africa. Recognized for his military genius, and as being among "the most dangerous" of corsairs, Dragut has been referred to as "the greatest pirate warrior of all time", "undoubtedly the most able of all the Turkish leaders", and "the uncrowned king of the Mediterranean". He was described by a French admiral as "a living chart of the Mediterranean, skillful enough on land to be compared to the finest generals of the time" and that "no one was more worthy than he to bear the name of king". Hayreddin Barbarossa, who was his mentor, stated that Dragut was ahead of him "both in fishing and bravery".
Hospitaller Malta, officially the Monastic State of the Order of Malta, and known within Maltese history as the Knights' Period, was a polity which existed between 1530 and 1798 when the Mediterranean islands of Malta and Gozo were ruled by the Order of St. John of Jerusalem. It was formally a vassal state of the Kingdom of Sicily, and it came into being when Emperor Charles V granted the islands as well as the city of Tripoli in modern Libya to the Order, following the latter's loss of Rhodes in 1522. Hospitaller Tripoli was lost to the Ottoman Empire in 1551, but an Ottoman attempt to take Malta in 1565 failed.
The Raid on Żejtun, also known as The Last Attack, was the last major attack made by the Ottoman Empire against the island of Malta, which was then ruled by the Order of St. John. The attack took place in July 1614, when raiders pillaged the town of Żejtun and the surrounding area before being beaten back to their ships by the Order's cavalry and by the inhabitants of the south-eastern towns and villages.
Tripoli, today the capital city of Libya, was a presidio of the Spanish Empire in North Africa between 1510 and 1530. The city was captured by Spanish forces in July 1510, and for the next two decades it was administered as an outpost which fell under the jurisdiction of the Spanish Viceroy of Sicily. The city was granted as a fief to the Knights Hospitaller in 1530, and the latter ruled the city until 1551.
Tripoli, today the capital city of Libya, was ruled by the Knights Hospitaller between 1530 and 1551. The city had been under Spanish rule for two decades before it was granted as a fief to the Hospitallers in 1530 along with the islands of Malta and Gozo. The Hospitallers found it difficult to control both the city and the islands, and at times they proposed to either move their headquarters to Tripoli or to abandon and raze the city. Hospitaller rule over Tripoli ended in 1551 when the city was captured by the Ottoman Empire following a siege.
The Spanish assault on Djerba was a 1510 military expedition directed by Ferdinand II of Aragon against the Tunisian island of Djerba. It resulted in the death of several thousand soldiers and is often known as the Djerba Disaster.
Crown of Aragon 
Kingdom of Sicily 
Hafsid dynasty