Lacking an immune system, protective shell, or mobility, sponges have developed an ability to synthesize a variety of unusual compounds for survival. C-nucleosides isolated from Caribbean Cryptotethya crypta , were the basis for the synthesis of zidovudine (AZT), aciclovir (Cyclovir), cytarabine (Depocyt), and cytarabine derivative gemcitabine (Gemzar).
Isolate | Source | Researched activity / Chemical description |
---|---|---|
3-Alkylpyridinium (3-AP) | Haplosclerida | hemolytic and cytotoxic [1] |
Agosterol A | anticancer [2] [3] | |
Aplyzanzine A | Aplysina sp. | |
Avarol | Dysidea avara | antitumor, antimicrobial [4] and antiviral [5] effects |
Aciculitin | Aciculites ciliate | antifungal cyclic peptide |
Discodermin | Discodermia kiiensis | antimicrobial tetradecapeptide |
Dysidenin | Lamellodysidea herbacea | Highly toxic [6] |
Girolline | Girolline | inhibits protein synthesis [7] |
Halichondrin B | Halichondria okadai Kadota (Miura Peninsula) | precursor to eribulin (Halaven) [8] [ dead link ] |
Halicylindramide | Halichondria | antifungal peptide |
Hymenamides | Phakellia fusca | proline-containing cyclopeptide [9] |
Hymenistatin | Phakellia fusca | bio-active proline-containing cyclopeptide |
Hyrtinadine A | Hyrtios | bio-active bis-indole alkaloid |
Manzamines | various sponge species | bio-active β-carbolines |
Mirabamide | Siliquariaspongia mirabilis | antiviral depsipeptide |
Neamphamide A | Neamphius huxleyi | antiviral depsipeptide |
Onnamide A | Theonella swinhoei | cytotoxic, inhibits protein synthesis [10] |
Peloruside A | Mycale sp. (New Zealand) | cytotoxic / structurally similar to bryostatin |
Phakellistatins | Phakellia fusca | proline-containing cyclopeptides [9] |
Phoriospongin | Phoriospongia and Callyspongia bilamellata | nematocidal compound |
Plakevulin A | Plakortis | DNA polymerase inhibitor |
Plakoridine A | Plakortis | |
Polydiscamide B | Ircinia | the first example of a nonendogenous human SNSR (human sensory neuron-specific G protein couple receptor) agonist [11] |
Ptilomycalin A | Monanchora arbuscula | antifungal spirocyclic guanidine alkaloid / laccase and melanization inhibitor |
Sceptrin | Agelas conifera | Antibiotic [12] |
Suberedamine | Suberea | |
Theonellamide F | Theonella | antimicrobial/antifungal cytotoxic bicyclic dodecapeptide [13] [14] |
Topsentolides | Topsentia | cytotoxic oxylipins [15] |
Xestoquinone | Xestospongia | Antimalarial, [16] antifungal, and cytotoxic [17] |
Semisynthetic analogs of the sponge isolate jasplakinolide, were submitted to National Cancer Institute’s Biological Evaluation Committee in 2011.
Trabectedin, aplidine, didemnin, were isolated from sea squirts. Monomethyl auristatin E is a derivative of a dolastatin 10, a compound made by Dolabella auricularia . Bryostatins were first isolated from Bryozoa .
Salinosporamides are derived from Salinispora tropica . Ziconotide is derived from the sea snail Conus magus .