TRNA pseudouridine13 synthase

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tRNA pseudouridine13 synthase
Identifiers
EC no. 5.4.99.27
CAS no. 430429-15-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
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NCBI proteins

tRNA pseudouridine13 synthase (EC 5.4.99.27, TruD, YgbO, tRNA PSI13 synthase, RNA:PSI-synthase Pus7p, Pus7p, RNA:pseudouridine-synthase Pus7p, Pus7 protein) is an enzyme with systematic name tRNA-uridine13 uracil mutase. [1] [2] [3] [4] [5] This enzyme catalyses the following chemical reaction

tRNA uridine13 tRNA pseudouridine13

Pseudouridine synthase TruD from Escherichia coli specifically acts on uridine13 in tRNA.

References

  1. ↑ Ericsson UB, Nordlund P, Hallberg BM (May 2004). "X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold". FEBS Letters. 565 (1–3): 59–64. Bibcode:2004FEBSL.565...59E. doi:10.1016/j.febslet.2004.03.085. PMID   15135053. S2CID   31602560.
  2. ↑ Chan CM, Huang RH (September 2009). "Enzymatic characterization and mutational studies of TruD--the fifth family of pseudouridine synthases". Archives of Biochemistry and Biophysics. 489 (1–2): 15–9. doi:10.1016/j.abb.2009.07.023. PMID   19664587.
  3. ↑ Kaya Y, Ofengand J (June 2003). "A novel unanticipated type of pseudouridine synthase with homologs in bacteria, archaea, and eukarya". RNA. 9 (6): 711–21. doi:10.1261/rna.5230603. PMC   1370438 . PMID   12756329.
  4. ↑ Behm-Ansmant I, Urban A, Ma X, Yu YT, Motorin Y, Branlant C (November 2003). "The Saccharomyces cerevisiae U2 snRNA:pseudouridine-synthase Pus7p is a novel multisite-multisubstrate RNA:Psi-synthase also acting on tRNAs". RNA. 9 (11): 1371–82. doi:10.1261/rna.5520403. PMC   1287059 . PMID   14561887.
  5. ↑ Urban A, Behm-Ansmant I, Branlant C, Motorin Y (February 2009). "RNA sequence and two-dimensional structure features required for efficient substrate modification by the Saccharomyces cerevisiae RNA:{Psi}-synthase Pus7p" (PDF). The Journal of Biological Chemistry. 284 (9): 5845–58. doi: 10.1074/jbc.m807986200 . PMID   19114708. S2CID   19586610.
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