Tartrazine

Last updated
Tartrazine
Tartrazine.svg
Tartrazine-3D-vdW.png
Names
IUPAC name
Trisodium 5-hydroxy-1-(4-sulfonatophenyl)-4-[(E)-(4-sulfonatophenyl)diazenyl]-1H-pyrazole-3-carboxylate
Other names
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.016.091 OOjs UI icon edit-ltr-progressive.svg
E number E102 (colours)
PubChem CID
UNII
  • InChI=1S/C16H12N4O9S2.3Na/c21-15-13(18-17-9-1-5-11(6-2-9)30(24,25)26)14(16(22)23)19-20(15)10-3-7-12(8-4-10)31(27,28)29;;;/h1-8,21H,(H,22,23)(H,24,25,26)(H,27,28,29);;;/q;3*+1/p-3/b18-17+;;; Yes check.svgY
    Key: YXHBBEQKMVAJOH-GLCFPVLVSA-K Yes check.svgY
  • InChI=1/C16H12N4O9S2.3Na/c21-15-13(18-17-9-1-5-11(6-2-9)30(24,25)26)14(16(22)23)19-20(15)10-3-7-12(8-4-10)31(27,28)29;;;/h1-8,21H,(H,22,23)(H,24,25,26)(H,27,28,29);;;/q;3*+1/p-3/b18-17+;;;
    Key: YXHBBEQKMVAJOH-KAGMCZNHBW
  • [Na+].[Na+].[Na+].[O-]S(=O)(=O)c1ccc(cc1)/N=N/c3c(nn(c2ccc(cc2)S([O-])(=O)=O)c3O)C([O-])=O
Properties
C16H9N4Na3O9S2
Molar mass 534.36 g·mol−1
20 g/100 mL
Solubility 18 g/100 mL in glycerol, negligible in ethanol
Hazards
NFPA 704 (fire diamond)
NFPA 704.svgHealth 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g. chloroformFlammability 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
2
1
0
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Yes check.svgY  verify  (what is  Yes check.svgYX mark.svgN ?)

Tartrazine is a synthetic lemon yellow azo dye primarily used as a food coloring. [1] [2] [3] [4] It is also known as E number E102, C.I. 19140, FD&C Yellow 5, Yellow 5 Lake, Acid Yellow 23, Food Yellow 4, and trisodium 1-(4-sulfonatophenyl)-4-(4-sulfonatophenylazo)-5-pyrazolone-3-carboxylate. [5]

Contents

Tartrazine is a commonly used color all over the world, mainly for yellow, and can also be used with brilliant blue FCF (FD&C Blue 1, E133) or green S (E142) to produce various green shades. It serves as a dye for wool and silks, a colorant in food, drugs and cosmetics and an adsorption-elution indicator for chloride estimations in biochemistry.

Products containing tartrazine

Foods

Easter eggs dyed with tartrazine Veligdenski jajtsa vaptsani so tartrazin.jpg
Easter eggs dyed with tartrazine

Many foods contain tartrazine in varying proportions, depending on the manufacturer or person preparing the food. When in food, tartrazine is typically labelled as "color", "tartrazine", or "E102", depending on the jurisdiction, and the applicable labeling laws (see Regulation below).

Products containing tartrazine commonly include processed commercial foods that have an artificial yellow or green color, or that consumers expect to be brown or creamy looking. It has been frequently used in the bright yellow coloring of imitation lemon filling in baked goods. The following is a list of foods that may contain tartrazine:[ citation needed ]

Personal care and cosmetics products

A number of personal care and cosmetics products may contain tartrazine, usually labelled as CI 19140 or FD&C Yellow 5, including:

Medications

Various types of medications include tartrazine to give a yellow, orange or green hue to a liquid, capsule, pill, lotion, or gel, primarily for easy identification. [6] Types of pharmaceutical products that may contain tartrazine include vitamins, antacids, cold medications (including cough drops and throat lozenges), lotions and prescription drugs.

Most, if not all, medication data sheets are required to contain a list of all ingredients, including tartrazine. Some include tartrazine in the allergens alert section.

The Canadian Compendium of Pharmaceuticals and Specialties (CPS), a prescribing reference book for health professionals, mentions tartrazine as a potential allergy for each drug that contains tartrazine.

Other products

Other products, such as household cleaning products, paper plates, pet foods, crayons, inks for writing instruments, stamp dyes, face paints, envelope glues, and deodorants, may also contain tartrazine.

Chemistry

Tartrazine is water-soluble [7] and has a maximum absorbance in an aqueous solution at 425 nm. [8] It is one of the oldest known members of the pyrazolone family of dyes. [9]

Potential health effects on humans

Sensitivity

Tartrazine appears to cause the most allergic and intolerance reactions of all the azo dyes, particularly among asthmatics and those with an aspirin intolerance. [10] Symptoms from tartrazine sensitivity can occur by either ingestion or cutaneous exposure to a substance containing tartrazine. Symptoms appear after periods of time ranging from minutes up to 14 hours. [11]

The prevalence of tartrazine intolerance is estimated at 360,000 U.S. Citizens affected, less than 0.12% of the general population. [12] According to the FDA, tartrazine causes hives in fewer than 1 in 10,000 people, or 0.01%. [13]

It is not clear how many individuals are sensitive or intolerant to tartrazine, but the University of Guelph estimates that it is 1 to 10 out of every ten thousand people (0.01% to 0.1% of the population). [14] There is much controversy about whether tartrazine has ill effects on individuals who are not clearly intolerant.[ citation needed ]

Total avoidance is the most common way to deal with tartrazine sensitivity, [15] but progress has been made in reducing people's tartrazine sensitivity in a study of people who are simultaneously sensitive to both aspirin and tartrazine. [16]

Asthma

A systematic review of the medical literature concluded that among patients with asthma, research has shown that exposure to tartrazine does not worsen symptoms and avoidance of tartrazine does not improve symptoms; however, "due to the paucity of evidence, it is not possible to provide firm conclusions as to the effects of tartrazine on asthma control". [17]

Food intolerance and ADHD-like behavior

Although tartrazine is one of various food colors said to cause food intolerance and ADHD-like behavior in children, evidence for this claim is lacking. [18] It is possible that certain food colorings may act as a trigger in those who are genetically predisposed, but the evidence for this effect is weak. [19] [20]

Myths

Rumors began circulating about tartrazine in the 1990s regarding a link to its consumption (specifically its use in Mountain Dew) and adverse effects on male potency, testicle and penis size, and sperm count. [21] There are no documented cases supporting the claim tartrazine will shrink a penis or cause it to stop growing. [22] [23]

Regulation

North America

Canada

Tartrazine is listed as a permitted food coloring in Canada. [24] The majority of pre-packaged foods are required to list all ingredients, including all food additives such as color; however section B.01.010 (3)(b) of the Regulations provide food manufacturers with the choice of declaring added color(s) by either their common name or simply as "colour". [25]

In February 2010, Health Canada consulted the public and manufacturers on their plans to change the labelling requirements. Health Canada felt that it might be prudent to require the identification of specific colors on food labels, to allow consumers to make better informed choices. [26] The results of the consultation supported increased transparency. [27] Some respondents proposed banning the use of synthetic food colors, however Health Canada found that existing scientific literature does not demonstrate that synthetic food coloring is unsafe in the general population; they are instead considering more transparent labelling to allow those with sensitivities to food color to make informed choices. The relevant proposed regulatory changes will be developed and published for consultation in Part I of the Canada Gazette, [28] the official newsletter of the Government of Canada.

United States

The United States requires the presence of tartrazine to be declared on food and drug products (21 CFR 74.1705 (revised April 2013), 21 CFR 201.20) and also color batches to be preapproved by the United States Food and Drug Administration (FDA). [13] As part of these regulations, the FDA requires that the Precautions section of prescription drug labels include the warning statement, "This product contains FD&C Yellow No. 5 (tartrazine) which may cause allergic-type reactions (including bronchial asthma) in certain susceptible persons. Although the overall incidence of FD&C Yellow No. 5 (tartrazine) sensitivity in the general population is low, it is frequently seen in patients who also have aspirin hypersensitivity." [29]

The FDA regularly seizes products if found to be containing undeclared tartrazine, declared but not FDA-tested, or labeled something other than FD&C yellow 5 or Yellow 5. Such products seized often include noodles. [30]

Europe

European Union

The European Food Safety Authority allows for tartrazine to be used in processed cheese, canned or bottled fruit or vegetables, processed fish or fishery products, and wines and wine-based drinks. [31] [32]

The European regulatory community, with a stronger emphasis on the precautionary principle, required labelling and temporarily reduced the acceptable daily intake (ADI) for the food colorings; the UK FSA called for voluntary withdrawal of the colorings by food manufacturers. [19] [33] However, in 2009 the EFSA re-evaluated the data at hand and determined that "the available scientific evidence does not substantiate a link between the color additives and behavioral effects." [19] [34]

Tartrazine is among six artificial colors for which the European Union requires products that contain them to be marked with the statement May have an adverse effect on activity and attention in children. [35]

Austria and Germany

Yellow tartrazine (E102) was banned in Austria [36] and Germany, before European Parliament and Council Directive 94/36/EC lifted the ban.

Norway

Yellow tartrazine (E102) is banned in Norway (not an E.U. member.) [37] [38]

United Kingdom

In response to concerns about the safety of certain food additives, the UK FSA commissioned a study by researchers at Southampton University of the effect of a mixture of six food dyes (Tartrazine, Allura Red, Ponceau 4R, Quinoline Yellow WS, Sunset Yellow and Carmoisine (dubbed the "Southampton 6")) and sodium benzoate (a preservative) on children in the general population, who consumed them in beverages; the study published in 2007. [19] [33] The study found "a possible link between the consumption of these artificial colours and a sodium benzoate preservative and increased hyperactivity" in the children; [19] [33] the advisory committee to the FSA that evaluated the study also determined that because of study limitations, the results could not be extrapolated to the general population, and further testing was recommended. [19]

Other uses

3D printing

Tartrazine has been used as a biocompatible photoblocker for generating transparent hydrogels with complex inner structures. [39]

See also

Related Research Articles

<span class="mw-page-title-main">Food coloring</span> Substance used to color to food or drink

Food coloring, or color additive, is any dye, pigment, or substance that imparts color when it is added to food or drink. They can be supplied as liquids, powders, gels, or pastes. Food coloring is used in both commercial food production and domestic cooking. Food colorants are also used in a variety of non-food applications, including cosmetics, pharmaceuticals, home craft projects, and medical devices. Colorings may be natural or artificial/synthetic.

<span class="mw-page-title-main">Quinoline Yellow WS</span> "Mixture of water-soluble organic compounds from Quinoline Yellow dye"

Quinoline Yellow WS is a mixture of organic compounds derived from the dye Quinoline Yellow SS. Owing to the presence of sulfonate groups, the WS dyes are water-soluble (WS). It is a mixture of disulfonates (principally), monosulfonates and trisulfonates of 2-(2-quinolyl)indan-1,3-dione with a maximum absorption wavelength of 416 nm.p. 119

Carmine – also called cochineal, cochineal extract, crimson lake, or carmine lake – is a pigment of a bright-red color obtained from the aluminium complex derived from carminic acid. Specific code names for the pigment include natural red 4, C.I. 75470, or E120. Carmine is also a general term for a particularly deep-red color.

<span class="mw-page-title-main">Annatto</span> Orange-red condiment and food coloring derived from the seeds of the achiote tree

Annatto is an orange-red condiment and food coloring derived from the seeds of the achiote tree, native to tropical parts of the Americas. It is often used to impart a yellow or orange color to foods, but sometimes also for its flavor and aroma. Its scent is described as "slightly peppery with a hint of nutmeg" and flavor as "slightly nutty, sweet and peppery".

<span class="mw-page-title-main">Sulfite</span> Oxyanion with a central atom of sulfur surrounded by 3 oxygen atoms

Sulfites or sulphites are compounds that contain the sulfite ion, SO2−
3
. The sulfite ion is the conjugate base of bisulfite. Although its acid is elusive, its salts are widely used.

<span class="mw-page-title-main">Sunset yellow FCF</span> Chemical compound used as colorant

Sunset yellow FCF is a petroleum-derived orange azo dye with a pH dependent maximum absorption at about 480 nm at pH 1 and 443 nm at pH 13 with a shoulder at 500 nm. When added to foods sold in the United States it is known as FD&C Yellow 6; when sold in Europe, it is denoted by E Number E110.

<span class="mw-page-title-main">Astaxanthin</span> Chemical compound

Astaxanthin is a keto-carotenoid within a group of chemical compounds known as terpenes. Astaxanthin is a metabolite of zeaxanthin and canthaxanthin, containing both hydroxyl and ketone functional groups. It is a lipid-soluble pigment with red coloring properties, which result from the extended chain of conjugated double bonds at the center of the compound. The presence of the hydroxyl functional groups and the hydrophobic hydrocarbons render the molecule amphiphilic.

<span class="mw-page-title-main">Canthaxanthin</span> Chemical compound

Canthaxanthin is a keto-carotenoid pigment widely distributed in nature. Carotenoids belong to a larger class of phytochemicals known as terpenoids. The chemical formula of canthaxanthin is C40H52O2. It was first isolated in edible mushrooms. It has also been found in green algae, bacteria, crustaceans, and bioaccumulates in fish such as carp, golden grey mullet, seabream and trush wrasse.

<span class="mw-page-title-main">Federal Food, Drug, and Cosmetic Act</span> Acts of the United States Congress

The United States Federal Food, Drug, and Cosmetic Act is a set of laws passed by the United States Congress in 1938 giving authority to the U.S. Food and Drug Administration (FDA) to oversee the safety of food, drugs, medical devices, and cosmetics. The FDA's principal representative with members of congress during its drafting was Charles W. Crawford. A principal author of this law was Royal S. Copeland, a three-term U.S. senator from New York. In 1968, the Electronic Product Radiation Control provisions were added to the FD&C. Also in that year the FDA formed the Drug Efficacy Study Implementation (DESI) to incorporate into FD&C regulations the recommendations from a National Academy of Sciences investigation of effectiveness of previously marketed drugs. The act has been amended many times, most recently to add requirements about bioterrorism preparations.

<span class="mw-page-title-main">Brilliant blue FCF</span> Chemical compound

Brilliant blue FCF is a synthetic organic compound used primarily as a blue colorant for processed foods, medications, dietary supplements, and cosmetics. It is classified as a triarylmethane dye and is known under various names, such as FD&C Blue No. 1 or acid blue 9. It is denoted by E number E133 and has a color index of 42090. It has the appearance of a blue powder and is soluble in water and glycerol, with a maximum absorption at about 628 nanometers. It is one of the oldest FDA-approved color additives and is generally considered nontoxic and safe.

<span class="mw-page-title-main">Erythrosine</span> Iodo-derivative of fluorone used as a pink dye

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<span class="mw-page-title-main">Ponceau 4R</span> Chemical compound

Ponceau 4R is a synthetic colourant that may be used as a food colouring. It is denoted by E Number E124. Its chemical name is 1-(4-sulfo-1-napthylazo)-2-napthol-6,8-disulfonic acid, trisodium salt. Ponceau is the generic name for a family of azo dyes.

<span class="mw-page-title-main">Allura Red AC</span> Chemical compound

Allura Red AC is a red azo dye that goes by several names, including FD&C Red 40. It is used as a food dye and has the E number E129.

<span class="mw-page-title-main">Azorubine</span> Chemical compound

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<span class="mw-page-title-main">Amaranth (dye)</span> Chemical compound

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<span class="mw-page-title-main">Soy allergy</span> Type of food allergy caused by soy

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The Feingold diet is an elimination diet initially devised by Benjamin Feingold following research in the 1970s that appeared to link food additives with hyperactivity; by eliminating these additives and various foods the diet was supposed to alleviate the condition.

<span class="mw-page-title-main">Lotion</span> Skin treatment preparation

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<span class="mw-page-title-main">Salicylate sensitivity</span> Medical condition

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References

  1. Food Standards Australia New Zealand. "Food Additives- Numerical List". Archived from the original on June 25, 2009. Retrieved 2 December 2009.
  2. Current EU approved additives and their E Numbers, Food Standards Agency website, retrieved 15 Dec 2011
  3. "Food Dyes". Center for Science in the Public Interest. Archived from the original on 6 July 2016. Retrieved 8 March 2013.
  4. "What is Food Coloring Made Of?". WiseGeek. Retrieved 8 March 2013.
  5. "Acid Yellow 23". ChemBlink, an online database of chemicals from around the world.
  6. "Tartrazine". drugs.com.
  7. Sigma-Aldrich. "SIGMA CHEMICAL COMPANY -- T0388 TARTRAZINE -- 6550-00F051158". siri.org. Archived from the original on 2016-03-03.
  8. Jain, Rajeev; Bhargava, Meenakshi; Sharma, Nidhi (2003). "Electrochemical Studies on a Pharmaceutical Azo Dye: Tartrazine". Industrial & Engineering Chemistry Research. 42 (2): 243–247. doi:10.1021/ie020228q.
  9. Hunger K, Herbst W (2012). "Pigments, Organic". Ullmann's Encyclopedia of Industrial Chemistry . Weinheim: Wiley-VCH. doi:10.1002/14356007.a20_371. ISBN   978-3527306732.
  10. "E102 Tartrazine, FD&C yellow No.5". UK Food Guide. Retrieved 2007-11-30.
  11. Alvarez Cuesta E, Alcover Sánchez R, Sainz Martín T, Anaya Turrientes M, García Rodríguez D (Jan–Feb 1981). "[Pharmaceutical preparations which contain tartrazine]". Allergol Immunopathol (Madr). 9 (1): 45–54. PMID   7258046.
  12. Elhkim MO, Héraud F, Bemrah N, et al. (April 2007). "New considerations regarding the risk assessment on Tartrazine: An update toxicological assessment, intolerance reactions and maximum theoretical daily intake in France". Regulatory Toxicology and Pharmacology . 47 (3): 308–316. doi:10.1016/j.yrtph.2006.11.004. PMID   17218045.
  13. 1 2 "Does FD&C Yellow No. 5 cause any allergic reactions?". United States Food and Drug Administration. Archived from the original on 2007-10-09. Retrieved 2007-10-20.
  14. Food Science | Educating Food Leaders for over 100 years
  15. Dipalma JR (November 1990). "Tartrazine sensitivity". American Family Physician. 42 (5): 1347–50. PMID   2239641.
  16. Michel O, Naeije N, Bracamonte M, Duchateau J, Sergysels R (May 1984). "Decreased sensitivity to tartrazine after aspirin desensitization in an asthmatic patient intolerant to both aspirin and tartrazine". Annals of Allergy. 52 (5): 368–70. PMID   6721262.
  17. Ardern KD, Ram FS (2014-01-24). "Tartrazine exclusion for allergic asthma". Cochrane Database Syst Rev. 2017 (4): CD000460. doi:10.1002/14651858.CD000460. PMC   6483719 . PMID   11687081.
  18. Tomaska LD; Brooke-Taylor, S (2013). Motarjemi Y; et al. (eds.). Food Additives – General. Vol. 2: Hazards and Diseases. Academic Press. p. 452. ISBN   9780123786135.{{cite book}}: |work= ignored (help)
  19. 1 2 3 4 5 6 FDA. Background Document for the Food Advisory Committee: Certified Color Additives in Food and Possible Association with Attention Deficit Hyperactivity Disorder in Children: March 30–31, 2011
  20. Millichap JG, Yee MM (February 2012). "The diet factor in attention-deficit/hyperactivity disorder". Pediatrics. 129 (2): 330–337. doi:10.1542/peds.2011-2199. PMID   22232312. S2CID   14925322.
  21. Bahloul, Maria (August 25, 2016). "Investigating the Middle School Rumor that Mountain Dew Lowers Your Sperm Count". Vice .
  22. "Re: DOES YELLOW 5 LOWER SPERM COUNT". Madsci.org. Retrieved 2012-11-10.
  23. "Mountain Dew Shrinks Testicles". snopes.com. 14 October 1999. Retrieved 2012-11-10.
  24. Table III of section B.16.100, Food and Drug Regulations
  25. Branch, Legislative Services (2022-01-05). "Consolidated federal laws of canada, Food and Drug Regulations". laws-lois.justice.gc.ca. Retrieved 2022-02-03.
  26. "Health Canada Proposal to Improve Food Colour Labelling Requirements". Health Canada. 2010-01-28. Retrieved 15 June 2012.
  27. Health Canada reviews comments received on the proposed changes to current food colour labelling regulations for prepackaged foods
  28. Canada Gazette
  29. CFR – Code of Federal Regulations Title 21
  30. ORA (May 2, 2013). "Import Alert 45-02". fda.gov. Retrieved May 5, 2013.
  31. "further details can be found on the EFSA food additives database page on tartrazine". Archived from the original on 2014-04-07. Retrieved 2014-04-06.
  32. "FOODS". Archived from the original on 2014-04-07. Retrieved 2014-04-06.
  33. 1 2 3 Sarah Chapman of Chapman Technologies on behalf of Food Standards Agency in Scotland. March 2011 [Guidelines on approaches to the replacement of Tartrazine, Allura Red, Ponceau 4R, Quinoline Yellow, Sunset Yellow and Carmoisine in food and beverages]
  34. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) (November 2009). "Scientific Opinion on the re-evaluation Tartrazine (E 102)". EFSA Journal. 7 (11): 1331–1382. doi: 10.2903/j.efsa.2009.1331 . The Panel concludes that the present dataset does not give reason to revise the ADI of 7.5 mg/kg bw/day.
  35. "Food additives". Food Standards Agency. Retrieved 2018-10-31.
  36. "Taste the rainbow forever: yellow mac & cheese is dead, but the nostalgia lives on". the Guardian. 21 April 2015. Retrieved 4 September 2022.
  37. Firman, Tehrene (21 August 2022). "American Food Products Banned In Other Countries". Eat This Not That.
  38. "Taste the rainbow forever: yellow mac & cheese is dead, but the nostalgia lives on". the Guardian. 21 April 2015. Retrieved 4 September 2022.
  39. Aaron, Benjamin (January 2019). "Light-based 3D Printing of Hydrogels with High-resolution Channels". Biomedical Physics & Engineering Express. 5 (2): 025035. doi: 10.1088/2057-1976/aad667 .