Interstate 26 (I-26) is a main route of the Interstate Highway System in the Southeastern United States. Nominally east–west, as indicated by its even number, I-26 runs from the junction of US Route 11W (US 11W) and US 23 in Kingsport, Tennessee, generally southeastward to US 17 in Charleston, South Carolina. The portion from Mars Hill, North Carolina, east to I-240 in Asheville, North Carolina, has signs indicating FUTURE I-26, because the highway does not yet meet all of the Interstate Highway standards.
The Tri-Cities is the region comprising the cities of Kingsport, Johnson City, and Bristol and the surrounding smaller towns and communities in Northeast Tennessee and Southwest Virginia. All three cities are located in Northeast Tennessee, while Bristol has a twin city of the same name in Virginia.
U.S. Route 11 or U.S. Highway 11 (US 11) is a major north–south United States Numbered Highway extending 1,645 miles (2,647 km) across the eastern U.S. The southern terminus of the route is at US 90 in Bayou Sauvage National Wildlife Refuge in eastern New Orleans, Louisiana. The northern terminus is at the Rouses Point–Lacolle 223 Border Crossing in Rouses Point, New York. The route continues across the border into Canada as Route 223. US 11, created in 1926, maintains most of its original route. The route north of Knoxville, Tennessee, follows a route similar to Interstate 81 (I-81). While it is signed as a north–south route, it physically travels in a northeast–southwest direction.
State Route 381 is a primary state highway in the US state of Virginia. Known as Commonwealth Avenue, the state highway runs 1.21 miles (1.95 km) from the Tennessee state line north to the 1.67-mile (2.69 km) Interstate 381 (I-381) within the independent city of Bristol. In conjunction with I-381, SR 381 connects I-81 with downtown Bristol. The state highway also connects the Interstate Highways with US Route 11 (US 11), US 11W, US 11E, US 19, and US 421; SR 381 runs concurrently with the latter three highways between downtown Bristol and US 11. I-381 is a spur from I-81 that provides access to Bristol. It runs for 1.67 miles (2.69 km) from the intersection of Commonwealth Avenue (SR 381) and Keys/Church streets in Bristol at exit 0 north to I-81. The I-81 interchange, the only one on I-381, is signed as exit 1A and exit 1B.
U.S. Route 11W (US 11W) is the western branch of US 11 from the twin cities of Bristol, Tennessee/Bristol, Virginia, where US 11 splits into US 11E and US 11W, to Knoxville, Tennessee, where the two highways rejoin. The highway serves the Appalachia region's Ridge-and-Valley section of East Tennessee, bounded by the Clinch Mountain ridge to the north and the Holston River to the south. US 11W from Bristol to Bean Station and Blaine to Knoxville are designated as part of the National Highway System.
U.S. Route 11E (US 11E) is a divided highway of US 11 in the U.S. states of Tennessee and Virginia. The United States Numbered Highway, which is complemented by US 11W to the north and west, runs 120.94 miles (194.63 km) from US 11, US 11W, and US 70 in Knoxville, Tennessee, north and east to US 11, US 11W, US 19, and US 421 in Bristol, Virginia. US 11E connects Knoxville and the twin cities of Bristol, Virginia, and Bristol, Tennessee, with the East Tennessee communities of Morristown, Greeneville, and Johnson City. The U.S. Highway runs concurrently with US 70 and US 25W east of Knoxville, US 321 from Greeneville and Johnson City, and both US 19W and US 19 between Johnson City and Bristol. US 11E also has an unsigned concurrency with State Route 34 (SR 34) for almost all of its course in Tennessee.
U.S. Route 11 (US 11) is a north–south United States Numbered Highway in western Virginia. At 339 miles (546 km), it is the second longest numbered route and longest primarily north–south route in the state. It enters the state from Tennessee as the divided routes US 11E and US 11W at Bristol, roughly follows the West Virginia border through the Blue Ridge Mountains and Shenandoah Valley, and enters the Eastern Panhandle of West Virginia from Frederick County. Most of the route closely parallels I-81. From south to north, US 11 serves the cities and towns of Bristol, Abingdon, Wytheville, Pulaski, Radford, Christiansburg, Roanoke, Lexington, Staunton, Harrisonburg, Strasburg, and Winchester. As one of the original U.S. Highways, it was first designated through Virginia in 1926 and has largely followed the same route since. Prior to the construction of the Interstate Highway System, it was the primary long-distance route for traversing the western part of the state. Much of it roughly follows the Great Wagon Road, a colonial-era road that followed the Appalachian Mountains from Georgia to Pennsylvania.
U.S. Route 421 (US 421) is a part of the U.S. Highway System that runs from Fort Fisher, North Carolina to Michigan City, Indiana. In Virginia, the U.S. Highway runs 69.23 miles (111.41 km) from the Tennessee state line between the twin cities of Bristol, Tennessee and Bristol, Virginia north and west to the Kentucky state line near St. Charles. Between its endpoints, US 421 has lengthy concurrencies with US 23 and US 58 during its course through Bristol, Weber City, Gate City, Duffield, and Pennington Gap in Southwest Virginia.
U.S. Route 19 (US 19) is a part of the United States Numbered Highway System that runs from Memphis, Florida, to Erie, Pennsylvania. In Virginia, the highway runs 88.89 miles (143.05 km) between two pairs of twin cities: Bristol, Tennessee, and Bristol, Virginia, at the Virginia–Tennessee state line, and Bluefield, Virginia, and Bluefield, West Virginia, at the Virginia–West Virginia state line. Between its endpoints, US 19 has lengthy concurrencies with US 11, US 58 Alternate, and US 460 during its course connecting Abingdon, Lebanon, and Tazewell within Washington, Russell, and Tazewell counties in Southwest Virginia.
Interstate 81 (I-81) is part of the Interstate Highway System that runs 855.02 miles (1,376.02 km) northward from Dandridge, Tennessee, to the Thousand Islands Bridge at the Canadian border near Fishers Landing, New York. In Tennessee, I-81 serves the northeastern part of the state, running 75.66 miles (121.76 km) from its southern terminus with I-40 in Dandridge to the Virginia state line in Bristol. The route serves the Tri-Cities region of the state and the eastern parts of the Knoxville metropolitan area, terminating about 35 miles (56 km) east of Knoxville. I-81 bypasses most cities that it serves, instead providing access via interchanges with state and federal routes. It remains in the Ridge-and-Valley topographic region of the Appalachian Mountains for its entire length in Tennessee, and runs in a northeast to southwest direction.
U.S. Route 11 (US 11) in the U.S. state of Tennessee travels from the Georgia state line in Chattanooga to Knoxville, where it then splits into US 11E and US 11W. These two highways then travel to the Virginia state line near Kingsport and Bristol. During its length, it shares concurrencies with State Route 2 (SR 2) and SR 38.
State Route 70 is a state-maintained highway in East Tennessee, beginning at the border with North Carolina in the midst of the Cherokee National Forest and the Great Smoky Mountains and ending at the Virginia border in the extremely rural and mountainous terrain of Hancock County.
State Route 107 is a 78.77-mile (126.77 km) state highway in eastern Tennessee, United States. It begins at an intersection with Round Mountain Road south of Del Rio and ends at the North Carolina state line east of Unicoi, where it becomes NC 226.
State Route 172 is a state highway in Greene County, Tennessee. It begins at a partially unsigned intersection with US 321 near downtown Greeneville and it is signed starting at its intersection with US 11E/US 321 Truck and ends at Interstate 81 in Baileyton.
State Route 36 (SR 36) is a 28.6-mile-long (46.0 km) state highway, broken in two segments. In Unicoi County, it serves as the hidden concurrency of U.S. Route 19W; in Washington and Sullivan counties, it serves as a stand-alone secondary road connecting the cities of Johnson City and Kingsport.
State Route 394 is a west–east state highway in Sullivan County, Tennessee. It serves as southern bypass of Bristol and as a connector route from Interstate 81 (I-81) to Bristol Motor Speedway. The western terminus is at an intersection with U.S. Route 11W northwest of Blountville and the eastern terminus is at a junction with US 421 southeast of Bristol. The route heads southeast and crosses I-81 before passing through Blountville. From here, SR 394 continues southeast to an interchange with US 11E/US 19 near Bristol Motor Speedway, where it turns northeast and continues to US 421.
State Route 32 is a state highway in East Tennessee. For most of its route, it is an unsigned companion route concurrent with U.S. Route 25E. The highway stretches 89 miles from the North Carolina state line to the Tennessee-Kentucky state line near the town of Cumberland Gap.
State Route 126 is a 24.6-mile-long (39.6 km) state highway that travels through Sullivan County in East Tennessee. It connects Kingsport and Bristol.
State Route 91 is a state highway in the northeastern portion of the U.S. state of Tennessee, in the area known as the Tri-Cities region. The route connects Johnson City with Damascus, Virginia via Elizabethton, Hunter, and Mountain City.
State Route 34 is an unsigned state highway located in East Tennessee. The 155.7-mile-long (250.6 km) route traverses several cities through eight counties from the Knoxville area to the North Carolina state line via Greeneville and Bristol. The portion from Carter to Bristol is concurrent with U.S. Route 11E (US 11E) while the portion from Bristol to North Carolina is concurrent with US 421.
US 11E / US 321 in Greeneville 
SR 224 at Bloomingdale 
