| Leg. | Senator | Party | Term start | Term end | Counties in District |
|---|
| 1st | William M. "Buckskin" Williams | Unknown | February 16, 1846 | December 13, 1847 | Fannin, Lamar |
| 2nd | December 13, 1847 | November 5, 1849 |
| 3rd | Matthias Ward | November 13, 1849 | November 3, 1851 | Bowie, Cass, Titus |
| 4th | Joseph H. Burks | November 3, 1851 | November 7, 1853 | Bowie, Red River |
| 5th | November 7, 1853 | November 5, 1855 |
| 6th | Solomon H. Pirkey | November 5, 1855 | November 7, 1859 |
| 7th |
| 8th | James W. Sims | November 7, 1859 | November 4, 1861 |
| 9th | Rufus K. Hartley | November 4, 1861 | August 6, 1866 | Chambers, Galveston, Jefferson, Liberty |
| 10th |
| 11th | Frederick Forney Foscue | August 6, 1866 | February 7, 1870 |
| 12th | Edward Bradford Pickett | Democratic | February 21, 1870 | January 13, 1874 | Chambers, Hardin, Jasper, Jefferson, Liberty, Newton, Orange, Polk, Tyler |
| 13th |
| 14th | Edwin Hobby | January 13, 1874 | April 18, 1876 |
| 15th | April 18, 1876 | July 10, 1879 | Chambers, Hardin, Jasper, Jefferson, Liberty, Newton, Orange, Polk, San Jacinto, Tyler |
| 16th |
| 17th | Samuel Bronson Cooper | January 11, 1883 | January 9, 1883 |
| 18th | January 9, 1883 | January 13, 1885 |
| 19th | William L. Douglass | January 13, 1885 | January 8, 1889 |
| 20th |
| 21st | Kennan B. Seale | January 8, 1889 | January 10, 1893 |
| 22nd |
| 23rd | Benjamin Whitaker | January 10, 1893 | January 12, 1897 | Bowie, Cass, Marion, Morris |
| 24th |
| 25th | Simon J. Morriss | January 12, 1897 | January 8, 1901 |
| 26th |
| 27th | James R. Wilson | January 8, 1901 | January 13, 1903 |
| 28th | January 13, 1903 | May 1, 1903 |
| 29th | James M. Terrell | January 10, 1905 | January 8, 1907 |
| 30th | January 8, 1907 | January 10, 1911 |
| 31st |
| 32nd | Horace W. Vaughan | January 14, 1911 | April 1, 1913 |
| 33rd |
| Absolom C. Oliver | August 13, 1913 | August 21, 1913 |
| John M. Henderson | September 11, 1914 | January 12, 1915 |
| 34th | January 12, 1915 | January 14, 1919 |
| 35th |
| 36th | Robert P. Dorough | January 14, 1919 | January 9, 1923 |
| 37th |
| 38th | Pleasant A. Turner | January 9, 1923 | January 13, 1925 |
| 39th | Lloyd E. Price | January 13, 1925 | January 8, 1929 | Bowie, Cass, Marion, Morris, Titus |
| 40th |
| 41st | John W. E. H. Beck | January 8, 1929 | January 10, 1993 |
| 42nd |
| 43rd | January 10, 1933 | March 24, 1936 |
| 44th |
| E. Harold Beck | September 28, 1936 | January 12, 1937 |
| 45th | January 12, 1937 | January 14, 1941 |
| 46th |
| 47th | January 14, 1941 | January 9, 1945 |
| 48th |
| 49th | Howard A. Carney | January 9, 1945 | January 11, 1949 |
| 50th |
| 51st | January 11, 1949 | January 13, 1953 |
| 52nd |
| 53rd | A. M. Aikin, Jr. | January 13, 1953 | January 11, 1955 | Bowie, Cass, Delta, Franklin, Hopkins, Lamar, Marion, Morris, Red River, Titus |
| 54th | January 11, 1955 | January 13, 1959 |
| 55th |
| 56th | January 13, 1959 | January 8, 1963 |
| 57th |
| 58th | January 8, 1963 | January 10, 1967 |
| 59th |
| 60th | January 10, 1967 | January 14, 1969 | Bowie, Camp, Cass, Delta, Fannin, Franklin, Harrison, Hopkins, Lamar, Marion, Morris, Red River, Titus |
| 61st | January 14, 1969 | January 9, 1973 |
| 62nd |
| 63rd | January 9, 1973 | January 14, 1975 | Bowie, Camp, Cass, Delta, Fannin, Franklin, Grayson, Harrison, Hopkins, Lamar, Marion, Morris, Red River, Titus |
| 64th | January 14, 1975 | January 9, 1979 |
| 65th |
| 66th | Vernon Edgar Howard | January 9, 1979 | January 11, 1983 |
| 67th |
| 68th | January 11, 1983 | January 8, 1985 | Bowie, Camp, Cass, Delta, Franklin, Gregg, Harrison, Hopkins, Lamar, Marion, Morris, Panola, Red River, Titus, Upshur |
| 69th | January 8, 1985 | September 18, 1986 |
| Richard M. Anderson | September 18, 1986 | January 10, 1989 |
| 70th |
| 71st | Bill Ratliff | Republican | January 10, 1989 | January 12, 1993 |
| 72nd |
| 73rd | January 12, 1993 | January 10, 1995 | Bowie, Camp, Cass, Delta, Franklin, Gregg, Harrison, Hopkins, Lamar, Marion, Morris, Panola, Red River, Rusk, Titus, Upshur |
| 74th | January 10, 1995 | January 12, 1999 | All of Bowie, Camp, Cass, Delta, Franklin, Gregg, Harrison, Hopkins, Lamar, Marion, Morris, Red River, Rusk, Titus, Upshur. Portion of Smith |
| 75th |
| 76th | January 12, 1999 | January 14, 2003 |
| 77th |
| 78th | January 14, 2003 | January 10, 2004 | All of Bowie, Camp, Cass, Franklin, Gregg, Harrison, Lamar, Marion, Morris, Panola, Red River, Rusk, Titus, Upshur, Wood. Portion of Smith |
| Kevin Eltife | March 5, 2004 | January 9, 2007 |
| 79th |
| 80th | January 9, 2007 | January 11, 2011 |
| 81st |
| 82nd | January 11, 2011 | January 8, 2013 |
| 83rd | January 8, 2013 | January 10, 2017 |
| 84th |
| 85th | Bryan Hughes | January 10, 2017 | January 12, 2021 |
| 86th |
| 87th | January 12, 2021 | January 10, 2023 |
| 88th | January 10, 2023 | January 14, 2025 | Bowie, Camp, Cass, Delta, Fannin, Franklin, Gregg, Harrison, Hopkins, Lamar, Marion, Morris, Panola, Red River, Rusk, Smith, Titus, Upshur, Wood |
| 89th | January 14, 2025 | present |