Toxocaridae

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Toxocaridae
Toxocara embryonated eggs.jpg
Toxocara embryonated eggs
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Eukaryota
Kingdom: Animalia
Phylum: Nematoda
Class: Chromadorea
Order: Ascaridida
Family: Toxocaridae
Genera

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Toxocara canis adult worms T. canis adult worms wiki.JPG
Toxocara canis adult worms

The Toxocaridae are a zoonotic family of parasitic nematodes that infect canids and felids and which cause toxocariasis in humans (visceral larva migrans and ocular larva migrans). [1] The worms are unable to reproduce in humans.

Contents

Notable species include:

Infection

Infection by T. canis or T. cati can cause various clinical manifestations. One of these is visceral larva migrans, wherein the larvae are unable to develop in humans as they do in cats and dogs, their natural hosts. Arrested development leaves the larvae to wander aimlessly in the body, causing inflammation, most commonly in the liver and lungs.

Eggs are introduced into the body through ingestion. This can occur when eggs are deposited on the hands or face, after handling infected dogs or cats. In some cases, they can also get them from undercooked meat. In children without exposure to animals, eggs can be introduced by directly ingesting egg-contaminated soil while playing in a yard or on a playground. Usually, the scenario involves a young child with a new puppy. Unfortunately, many young children who have been infected with these larvae, causing ocular larva migrans in the eye, have been misdiagnosed to have retinoblastoma and have had their eyes erroneously removed.

Diagnosis

Direct identification of larvae in human disease is not feasible, so the diagnosis relies on history supported by serologic ELISA assay. The most sensitive assay, called excretory/secretory (E/S), contains 96 immunogenic antigens isolated from cultured T. canis larvae.

Prevention

A number of products supplied by veterinarians can prevent or treat infections with this parasite. A great deal of information on this subject can be found on the computer sites maintained by the Companion Animal Parasite Council.[ citation needed ]

Treatment

Visceral toxocariasis in humans (or dogs) can be treated with antiparasitic drugs such as albendazole or mebendazole, usually in combination with anti-inflammatory medications. Treatment for ocular larva migrans is to kill the larvae with a laser to prevent further damage, although some loss of vision in the affected eye is irreversible.

Association with asthma

Infection with Toxocara has been shown to stimulate atopic disease, specifically asthma. [4] Infection with this parasite causes asthma-like symptoms such as accumulation of eosinophils, an inflammatory response, and production of IgE, the immunoglobulins associated with allergic responses. [5] People with asthma are shown to have a higher prevalence of Toxocara seropositivity. [6] Research suggests that the IgE production stimulated by infection with Toxocara may contribute to the onsets of allergic asthma in children. [4] The effects of how parasite load, frequency of exposure, and influence of genetics affect this relationship between Toxocara infection and allergic asthma are still unknown, yet important in understanding how to prevent asthma and other atopic diseases around the globe. [4]

See also

Related Research Articles

Toxocariasis is an illness of humans caused by the dog roundworm and, less frequently, the cat roundworm. These are the most common intestinal roundworms of dogs, coyotes, wolves and foxes and domestic cats, respectively. Humans are among the many "accidental" or paratenic hosts of these roundworms.

Gnathostomiasis, also known as larva migrans profundus, is the human infection caused by the nematode Gnathostoma spinigerum and/or Gnathostoma hispidum, which infects vertebrates.

<span class="mw-page-title-main">Albendazole</span> Chemical compound

Albendazole is a broad-spectrum anthelmintic and antiprotozoal agent of the benzimidazole type. It is used for the treatment of a variety of intestinal parasite infections, including ascariasis, pinworm infection, hookworm infection, trichuriasis, strongyloidiasis, taeniasis, clonorchiasis, opisthorchiasis, cutaneous larva migrans, giardiasis, and gnathostomiasis, among other diseases.

<i>Dipylidium caninum</i> Species of flatworm

Dipylidium caninum, also called the flea tapeworm, double-pored tapeworm, or cucumber tapeworm is a cyclophyllid cestode that infects organisms afflicted with fleas and canine chewing lice, including dogs, cats, and sometimes human pet-owners, especially children.

<span class="mw-page-title-main">Cutaneous larva migrans</span> Medical condition

Cutaneous larva migrans is a skin disease in humans, caused by the larvae of various nematode parasites of the hookworm family (Ancylostomatidae). The parasites live in the intestines of dogs, cats, and wild animals; they should not be confused with other members of the hookworm family for which humans are definitive hosts, namely Ancylostoma duodenale and Necator americanus.

Visceral larva migrans (VLM) is a condition in humans caused by the migratory larvae of certain nematodes, humans being a dead-end host, and was first reported in 1952. Nematodes causing such zoonotic infections are Baylisascaris procyonis, Toxocara canis, Toxocara cati, and Ascaris suum. These nematodes can infect but not mature in humans and after migrating through the intestinal wall, travel with the blood stream to various organs where they cause inflammation and damage. Affected organs can include the liver, heart and the CNS. A special variant is ocular larva migrans where usually T. canis larvae travel to the eye.

<span class="mw-page-title-main">Pooper-scooper</span> Device used to pick up animal feces

A pooper-scooper, or poop scoop, is a device used to pick up animal feces from public places and yards, particularly those of dogs. Pooper-scooper devices often have a bag or bag attachment. 'Poop bags' are alternatives to pooper scoopers, and are simply a bag, usually turned inside out, to carry the feces to a proper disposal area. Sometimes, the person performing the cleanup is also known as the pooper-scooper.

Sparganosis is a parasitic infection caused by the plerocercoid larvae of the genus Spirometra including S. mansoni, S. ranarum, S. mansonoides and S. erinacei. It was first described by Patrick Manson in 1882, and the first human case was reported by Charles Wardell Stiles from Florida in 1908. The infection is transmitted by ingestion of contaminated water, ingestion of a second intermediate host such as a frog or snake, or contact between a second intermediate host and an open wound or mucous membrane. Humans are the accidental hosts in the life cycle, while dogs, cats, and other mammals are definitive hosts. Copepods are the first intermediate hosts, and various amphibians and reptiles are second intermediate hosts.

Uncinaria stenocephala is a nematode that parasitizes dogs, cats, and foxes as well as humans. It is rare to find in cats in the United States. Uncinaria stenocephala is the most common canine hookworm in cooler regions, such as Canada and the northern regions of the US, where it can be found primarily in foxes (40%). U. stenocephala is also one of the most common hookworms in the UK, called the northern hookworm, however it has a rather low prevalence. U. stenocephala is also considered to be zoonotic hookworms because they live in animals but can be transmitted to humans.

<span class="mw-page-title-main">Ocular larva migrans</span> Medical condition

Ocular larva migrans (OLM), also known as ocular toxocariasis, is the ocular form of the larva migrans syndrome that occurs when Toxocara canis larvae invade the eye. They may be associated with visceral larva migrans. Unilateral visual disturbances, strabismus, and eye pain are the most common presenting symptoms.

<span class="mw-page-title-main">Ancylostomiasis</span> Medical condition

Ancylostomiasis is a hookworm disease caused by infection with Ancylostoma hookworms. The name is derived from Greek ancylos αγκύλος "crooked, bent" and stoma στόμα "mouth".

<i>Toxocara canis</i> Species of roundworm

Toxocara canis is a worldwide-distributed helminth parasite that primarily infects dogs and other canids, but can also infect other animals including humans. The name is derived from the Greek word "toxon," meaning bow or quiver, and the Latin word "caro," meaning flesh. T. canis live in the small intestine of the definitive host. This parasite is very common in puppies and somewhat less common in adult dogs. In adult dogs, infection is usually asymptomatic but may be characterized by diarrhea. By contrast, untreated infection with Toxocara canis can be fatal in puppies, causing diarrhea, vomiting, pneumonia, enlarged abdomen, flatulence, poor growth rate, and other complications.

<i>Toxocara cati</i> Species of worm

Toxocara cati, also known as the feline roundworm, is a parasite of cats and other felids. It is one of the most common nematodes of cats, infecting both wild and domestic felids worldwide. Adult worms are localised in the gut of the host. In adult cats, the infection – which is called toxocariasis – is usually asymptomatic. However, massive infection in juvenile cats can be fatal.

<i>Toxascaris leonina</i> Species of roundworm

Toxascaris leonina is a common parasitic roundworm found in dogs, cats, foxes, and related host species. T. leonina is an ascarid nematode, a worldwide distributed helminth parasite which is in a division of eukaryotic parasites that, unlike external parasites such as lice and fleas, live inside their host. The definitive hosts of T. leonina include canids and felines (cats), while the intermediate hosts are usually rodents, such as mice or rats. Infection occurs in the definitive host when the animal eats an infected rodent. While T. leonina can occur in either dogs or cats, it is far more frequent in cats.

<i>Ancylostoma braziliense</i> Species of worm

Ancylostoma braziliense is a species of hookworm belonging to the genus Ancylostoma. It is an intestinal parasite of domestic cats and dogs. Severe infection is often fatal to these pets, especially in puppies and kittens. The infection is particularly endemic in the southern United States. It is most often confused with the zoonotic hookworm species Ancylostoma ceylanicum because of their uncanny resemblance.

Trichuris vulpis is a whipworm that lives in the large intestine of canines in its adult stages. Out of different types of worms, Trichuris vulpis is one of the smaller worms with a size ranging from 30–50 mm in length. As the name suggests, the worm has a whip-like shape with distinct features including a small, narrow anterior head, which is the digestive part of the worm, and a larger posterior tail, which is the reproductive part of the worm. Eggs from T. vulpis are oval shaped with bipolar plugs and contain a thick outer shell. Their sizes range from 72–90 μm in length and 32–40 μm in width. Because of their thick outer shell, T. vulpis eggs are very resistant to environmental extremes such as freezing or hot temperatures, thus allowing for their long viability in the outside world.

<i>Baylisascaris procyonis</i> Species of roundworm

Baylisascaris procyonis, also known by the common name of raccoon roundworm, is a roundworm nematode, found ubiquitously in raccoons, the definitive hosts. It is named after H. A. Baylis, who studied them in the 1920s–30s, and Greek askaris. Baylisascaris larvae in paratenic hosts can migrate, causing larva migrans. Baylisascariasis as the zoonotic infection of humans is rare, though extremely dangerous due to the ability of the parasite's larvae to migrate into brain tissue and cause damage. Concern for human infection has been increasing over the years due to urbanization of rural areas resulting in the increase in proximity and potential human interaction with raccoons.

Gnathostoma hispidum is a nematode (roundworm) that infects many vertebrate animals including humans. Infection of Gnathostoma hispidum, like many species of Gnathostoma causes the disease gnathostomiasis due to the migration of immature worms in the tissues.

<span class="mw-page-title-main">Cat worm infections</span> Worm infections in cats

Cat worm infections, the infection of cats (Felidae) with parasitic worms, occur frequently. Most worm species occur worldwide in both domestic and other cats, but there are regional, species and lifestyle differences in the frequency of infestation. According to the classification of the corresponding parasites in the zoological system, infections can be divided into those caused by nematode and flatworms - in the case of the latter, mainly cestoda and trematoda - while other strains are of no veterinary significance. While threadworms usually do not require an intermediate host for their reproduction, the development cycle of flatworms always proceeds via alternate hosts.

<span class="mw-page-title-main">Nematode infection in dogs</span> Threadworm infections of dogs are frequent

Nematode infection in dogs - the infection of dogs with parasitic nemamotodes - are, along with tapeworm infections and infections with protozoa, frequent parasitoses in veterinary practice. Nematodes, as so-called endoparasites, colonize various internal organs - most of them the digestive tract - and the skin. To date, about 30 different species of nematode have been identified in domestic dogs; they are essentially also found in wild dog species. However, the majority of them often cause no or only minor symptoms of disease in adult animals. The infection therefore does not necessarily have to manifest itself in a worm disease (helminthosis). For most nematodes, an infection can be detected by examining the feces for eggs or larvae. Roundworm infection in dogs and the hookworm in dogs is of particular health significance in Central Europe, as they can also be transmitted to humans (zoonosis). Regular deworming can significantly reduce the frequency of infection and thus the risk of infection for humans and dogs.

References

  1. Fan CK, Holland CV, Loxton K, Barghouth U (July 2015). "Cerebral Toxocariasis: Silent Progression to Neurodegenerative Disorders?". Clin Microbiol Rev. 28 (3): 663–86. doi:10.1128/CMR.00106-14. PMC   4462679 . PMID   26062575.
  2. Despommier, Dickson (April 2003). "Toxocariasis: clinical aspects, epidemiology, medical ecology, and molecular aspects". Clinical Microbiology Reviews. 16 (2): 265–72. doi:10.1128/CMR.16.2.265-272.2003. PMC   153144 . PMID   12692098.
  3. Uzal, Francisco A.; Plattner, Brandon L.; Hostetter, Jesse M. (2016). "Chapter 1. Alimentary system. Gastrointestinal helminthosis. Toxacara vitulorum". In Maxie, M. Grant (ed.). Jubb, Kennedy & Palmer's Pathology of Domestic Animals Volume 2 (6th ed.). St Louis, Missouri: Elsevier. p. 220. ISBN   978-0-7020-5318-4.
  4. 1 2 3 Holland, Celia, and H. V. Smith. Toxocara: The Enigmatic Parasite. Wallingford, UK: CABI Pub., 2006. Print.
  5. Pinelli, E., J. Dormans, and I. Van Die. "Toxocara and Asthma." Toxocara: The Enigmatic Parasite (n.d.): 42-57. Web.
  6. Cobzaru, RG, C. Rîpă, MM Leon, MC Luca, A. Ivan, and M. Luca. "Result Filters." National Center for Biotechnology Information. U.S. National Library of Medicine, 2012. Web. 02 Oct. 2016.