Trichinella britovi

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Trichinella britovi
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Eukaryota
Kingdom: Animalia
Phylum: Nematoda
Class: Enoplea
Order: Trichocephalida
Family: Trichinellidae
Genus: Trichinella
Species:
T. britovi
Binomial name
Trichinella britovi
Pozio, la-Rosa, Murrell & Lichtenfels, 1992

Trichinella britovi is a nematode parasite responsible for a zoonotic disease called trichinellosis. Currently, eight species of Trichinella are known, [1] only three of which cause trichinellosis, and Trichinella britovi is one of them. [2] Numerous mammal species, as well as birds and crocodiles, [1] [2] can harbor the parasite worldwide, but the sylvatic cycle is mainly maintained by wild carnivores. [2] [3] [4]

Contents

Humans represent only a possible host and the parasite is exclusively transmitted through consumption of raw or Rare Meat. [2] In Europe, pork and wild boar meat are the main sources for human infection. [2]

Because of mandatory veterinary controls in slaughterhouses, large trichinellosis outbreaks due to horse-meat consumption are rare, but cases in hunters and their families after raw or rare wild boar meat consumption are regularly reported, with over 100 cases since 1975. [5]

Pork sausages eaten raw by consumers caused an outbreak of trichinellosis in 2015 in France. Parasite160031-fig1 Figatelli (pork sausages) with inadequate labelling.tif
Pork sausages eaten raw by consumers caused an outbreak of trichinellosis in 2015 in France.

Trichinella britovi can be found in Europe and western Asia among carnivores such as wild boars, pigs, bears, etc. [6]

T. britovi in wild boar is relatively resistant to freezing. In France, meat from naturally infected wild boar meat frozen for three weeks at −20 °C (−4 °F) remained infectious, whereas the parasites were not viable after four weeks. [7]

In the 1960s, "trichinella infection" was documented in Senegal, West Africa. A survey of 160 wild animals from that region produced plausible evidence that European strains may have originated in Africa. It has also been proposed that strains of T. britovi are isolated to both African and European populations. [8]

Three cases of human trichinellosis due to T. britovi were reported in 2015 in the Southeast of France resulting from consumption of raw pork sausages (figatelli) prepared in Corsica. Fourteen other people ate figatelli from the same batch, but were not infected due to the figatelli being well cooked. [9]

Several outbreaks of human trichinellosis happened in the South of France or in the Piedmont region in Italy from 1993 to 2022, generally caused by the consumption of undercooked wild boar meat. [10]

Hosts and Life Cycle

There is not one preferred host or definitive host for Trichinella. [6] The adults worms and the developing larvae inhabit the same infected vertebrate host that will serve as the definitive host and possibly even the intermediate host. [6] The life cycle of all species in the genus Trichinella consist of two generations, reproductive adults and larvae that grow to the infective state, where the larvae will encyst in mammalian hosts. [11] The hosts that affect infections in humans include the following: pigs, horses, wild boars, dogs, walruses, foxes, moose, and bears. [6] [11]

Its life cycle begins with the ingestion of an infected animal's meat, or muscle tissue where the larvae of the parasite were encysted. [6] [11] The larvae are released when digested in the stomach and penetrate the intestinal mucosa of the small intestine where in about 48 hours, the larvae will reach their adult stage. [11] The male and female adults mate and after 5-7 days after infection, the female worms release new larvae into the lymphatic and blood vessels. [11] The larvae use these vessels as transportation to the highly oxygenated muscle cells in the body. [11] Within a few weeks, the host's immune response with kill all of the adult worms in the body and the larvae will begin to penetrate the muscle tissue/cells. [11] The larvae will develop into the infective stage within the infected muscle cells that are now call nurse cells [12] and encyst in the muscle tissue. [11] [6] After a certain period of time, this could be week, months, or even years, the cysts will undergo a calcification process if the larvae not ingested by another animal. [11]

Symptoms and Diagnosis

Light infections may be show no signs of infection (asymptomatic). [6] In cases where the adult worms have begun reproducing, you may see gastrointestinal symptoms such as diarrhea, abdominal pain, vomiting. [6] When the larvae penetrate into the muscle cell and start encysting, it can cause periorbital and facial edema, conjunctivitis, fever, myalgias, splinter hemorrhages, rashes, and peripheral eosinophilia. [6] There can be life-threatening effects myocarditis, central nervous system involvement, and pneumonitis, however, they are uncommon. [6]

To confirm a diagnosis of trichinellosis by T. britovi, the larvae must be found in the blood by serology or encysted larvae must be found in a biopsy or autopsy of the infected host. [6]

Prevention

To prevent trichinellosis, an official European directive [13] recommends the freezing of meat at −25 °C (−13 °F) for at least 10 days for pieces of meat less than 25 cm (10 in) in thickness. Patients froze wild boar steaks at −35 °C (−31 °F) for seven days, but this freezing time appears insufficient to kill larvae, since T. britovi is a species relatively resistant to freezing. [14]

Thus according to the International Commission on Trichinellosis, meat should be heated at 65 °C (149 °F) for at least 1 minute to kill Trichinella larvae; larvae die when the color of the meat at the core changes from pink to brown. [15]

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References

  1. 1 2 Mowlavi, Gholamreza; Marucci, Gianluca; Mobedi, Iraj; Zahabiioon, Farzaneh; Mirjalali, Hamed; Pozio, Edoardo (2009). "Trichinella britovi in a leopard (Panthera pardus saxicolor) in Iran". Veterinary Parasitology. 164 (2–4): 350–352. doi:10.1016/j.vetpar.2009.05.001. PMID   19497675.
  2. 1 2 3 4 5 Gari-Toussaint, M.; Tieulié, N.; Baldin, J.L; Dupouy-Camet, J.; Delaunay, P.; Fuzibet, J.G.; Fichoux, Y. L.; Pozio, E.; Marty, P. (2005). "Human trichinellosis due to Trichinella britovi in Southern France after consumption of wild boar meat". Eurosurveillance. 10 (6): 117–118. doi: 10.2807/esm.10.06.00550-en . PMID   16077211.
  3. ↑ Kärssin, A; Häkkinen, L; Vilem, A; Jokelainen, P; Lassen, B (2021). "Trichinella spp. In wild boars (sus scrofa), brown bears (ursus arctos), eurasian lynxes (lynx lynx) and badgers (meles meles) in estonia, 2007–2014". Animals. 11 (1): 183. doi: 10.3390/ani11010183 . PMC   7830479 . PMID   33466833.
  4. ↑ Kärssin, A; Häkkinen, L; Niin, E; Peik, K; Vilem, A; Jokelainen, P; Lassen, B (2017). "Trichinella spp. biomass has increased in raccoon dogs (Nyctereutes procyonoides) and red foxes (Vulpes vulpes) in Estonia". Parasit Vectors. 10 (1): 609. doi: 10.1186/s13071-017-2571-0 . PMC   5732378 . PMID   29246168.
  5. ↑ Dupouy-Camet, J.; Ancelle, T. (2002). "Zoonoses parasitaires transmises par la chair animale en France" [Zoonotic parasites transmitted by animal flesh in France](PDF). La Lettre de l'Infectiologue (in French). XVII (5): 143–148.
  6. 1 2 3 4 5 6 7 8 9 10 11 "CDC - DPDx - Trichinellosis". Centers for Disease Control and Prevention. 23 January 2019. Retrieved 12 December 2023.
  7. ↑ Pozio, E.; La Rosa, G.; Mignone, W.; Amati, M.; Ercolini, C. (1992). "Sopravvivenza delle larve muscolari di Trichinella britovi nei muscoli congelati di cinghiale". Archivo Veterinario Italiano. 43 (2): 57–60.
  8. ↑ Pozio, E.; Pagani, P.; Marucci, G.; Zarlenga, D. S.; et al. (1971). "Trichinella britovi etiological agent of sylvatic trichinellosis in the Republic of Guinea (West Africa) and a re-evaluation of geographical distribution for encapsulated species in Africa". International Journal for Parasitology. Elsevier Science. Retrieved 8 December 2009.
  9. ↑ Ruetsch, Caroline; Delaunay, Pascal; Armengaud, Alexis; Peloux-Petiot, Françoise; Dupouy-Camet, Jean; Vallée, Isabelle; Polack, Bruno; Boireau, Pascal; Marty, Pierre (2016). "Inadequate labeling of pork sausages prepared in Corsica causing a trichinellosis outbreak in France". Parasite. 23: 27. doi:10.1051/parasite/2016027. ISSN   1776-1042. PMC   4912683 . PMID   27317463. Open Access logo PLoS transparent.svg
  10. ↑ Peju, Martin; Granier, Bérangère; Garnaud, Cécile; Brenier-Pinchart, Marie-Pierre; Vallée, Isabelle; Chevillot, Aurélie; Mérel, Charlotte; Chereau, Fanny; Deher, Muriel; Rogeaux, Olivier; Yera, Hélène (2023). "A Trichinella britovi outbreak in the Northern Alps of France: investigation by a local survey network". Parasite. 30: 14. doi:10.1051/parasite/2023017. PMC   10177977 . PMID   37171388. Open Access logo PLoS transparent.svg
  11. 1 2 3 4 5 6 7 8 9 Gottstein, Bruno; Pozio, Edoardo; Nöckler, Karsten (January 2009). "Epidemiology, Diagnosis, Treatment, and Control of Trichinellosis". Clinical Microbiology Reviews. 22 (1): 127–145. doi:10.1128/CMR.00026-08. ISSN   0893-8512. PMC   2620635 . PMID   2620635.
  12. ↑ Wu, Zhiliang; Sofronic-Milosavljevic, Lj; Nagano, Isao; Takahashi, Yuzo (19 August 2008). "Trichinella spiralis: nurse cell formation with emphasis on analogy to muscle cell repair". Parasites & Vectors. 1 (1): 9–16. doi: 10.1186/1756-3305-1-27 . ISSN   1756-3305. PMC   2538513 . PMID   2538513.
  13. ↑ Council Directive 77/96/EEC of 21 December 1976 on the examination for trichinae (Trichinella spiralis) upon importation from third countries of fresh meat derived from domestic swine. O.J. No L26 of 31.1.1977, p. 67.
  14. ↑ Pozio, E.; Zarlenga, D. S. (October 2005). "Recent advances on the taxonomy, systematics and epidemiology of Trichinella". International Journal for Parasitology. 35 (11–12): 1191–204. doi:10.1016/j.ijpara.2005.07.012. PMID   16153648.
  15. ↑ Gamble, H. R.; Bessonov, A. S.; Cuperlovic, K.; Gajadhar, A. A.; van Knapen, F.; Noeckler, K.; Schenone, H.; Zhu, X. (1 December 2000). "International Commission on Trichinellosis: recommendations on methods for the control of Trichinella in domestic and wild animals intended for human consumption". Veterinary Parasitology. 93 (3–4): 393–408. doi:10.1016/S0304-4017(00)00354-X. PMID   11099850.
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