Trichophyton

Last updated

Trichophyton
Trichophyton rubrum var rodhaini.jpg
Trichophyton rubrum
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Eukaryota
Kingdom: Fungi
Division: Ascomycota
Class: Eurotiomycetes
Order: Onygenales
Family: Arthrodermataceae
Genus: Trichophyton
Malmsten

Trichophyton is a genus of fungi, which includes the parasitic varieties that cause tinea, including athlete's foot, ringworm, jock itch, and similar infections of the nail, beard, skin and scalp. Trichophyton fungi are molds characterized by the development of both smooth-walled macro- and microconidia. Macroconidia are mostly borne laterally directly on the hyphae or on short pedicels, and are thin- or thick-walled, clavate to fusiform, and range from 4 to 8 by 8 to 50 μm in size. Macroconidia are few or absent in many species. Microconidia are spherical, pyriform to clavate or of irregular shape, and range from 2 to 3 by 2 to 4 μm in size.

Contents

Species and their habitat preference

According to current classification, the genus includes anthropophilic and zoophilic species. [1] Anthropophilic fungi prefer to infect humans. Zoophilic fungi prefer to infect animals other than humans. Humans and other animals are natural reservoirs for parasitic or dermatophytic fungi.

NameBotanical authorEnvironment
Trichophyton benhamiae (Ajello & S.L. Cheng) Y. Gräser & de Hoog (2018) zoophilic
Trichophyton bullosum Lebasque (1933) zoophilic
Trichophyton concentricum R. Blanch. (1895) anthropophilic
Trichophyton equinum Gedoelst (1902) zoophilic (horse)
Trichophyton erinacei (J.M.B. Smith & Marples) Quaife (1966) zoophilic (hedgehog)
Trichophyton eriotrephon Papeg. (1925)
Trichophyton mentagrophytes (C.P. Robin) Sabour. (1895) zoophilic (hedgehog)
Trichophyton quinckeanum (Zopf ex Guég.) D.M. MacLeod & Muende (1940) zoophilic (mouse)
Trichophyton rubrum (Castell.) Sabour. (1911) anthropophilic
Trichophyton schoenleinii (Lebert) Langeron & Miloch. ex Nann. (1934) anthropophilic
Trichophyton simii (Pinoy) Stockdale, D.W.R. Mack. & Austwick (1965) zoophilic (monkey, fowl)
Trichophyton soudanense Joyeux (1912) anthropophilic
Trichophyton tonsurans Malmsten (1848) anthropophilic
Trichophyton verrucosum E. Bodin (1902) zoophilic (cattle, horse)
Trichophyton violaceum Sabour. ex E. Bodin (1902) anthropophilic

Other accepted species; [2]

Mating and meiosis

Trichophyton mentagrophytes (Family Arthrodermataceae, Genus Trichophyton) is capable of both mating [3] and meiosis. [4]

Effect on humans

The anthropophilic varieties cause forms of dermatophytosis, that is, fungal infection of the skin. They are keratinophilic: they feed on the keratin in nails, hair, and dead skin.

Trichophyton concentricum causes "Malabar itch", a skin infection consisting of an eruption of a number of concentric rings of overlapping scales forming papulosquamous patches. [5]

Trichophyton rubrum and Trichophyton interdigitale cause athlete's foot (tinea pedis), toenail fungal infections (a.k.a. tinea unguium, a.k.a. onychomycosis), crotch itch (a.k.a. tinea cruris), and ringworm (a misnomer, as there is no worm involved; it is also known as tinea corporis). Trichophyton schoenleinii cause favus (tinea capitis),Trichophyton mentagrophytes var. mentagrophytes and Trichophyton verrucosum cause kerion (violent reaction results from infection with an animal dermatophytes).[ citation needed ] Fungal folliculitis is a rare hair follicle infection induced overwhelmingly by Trichophyton, which can be spread zoonotically. [6] [7] The fungi can easily spread to other areas of the body as well and to the host's home environs (socks, shoes, clothes, showers, bathtubs, counters, floors, carpets, etc.).

They can be transmitted by direct contact, by contact with infested particles (of dead skin, nails, hair) shed by the host, and by contact with the fungi's spores. These fungi thrive in warm moist dark environments, such as in the dead upper layers of skin between the toes of a sweaty foot inside a tightly enclosed shoe, or in dead skin particles on the wet floor of a communal (shared) shower. Their spores are extremely difficult to eliminate, and spread everywhere.

When the hyphae of the fungi burrow into the skin and release enzymes to digest keratin, they may irritate nerve endings and cause the host to itch, which may elicit the scratch reflex, which directs the host to scratch. Scratching directly transfers fungi and dead skin particles that are infested with the fungi to the fingers and under the finger nails. From there they can be transmitted to other parts of the host's body when the host touches or scratches those. Scratching also damages skin layers, making it easier for the fungi to spread at the site of the infection. If the fungi and infested debris are not washed from the fingers and fingernails soon enough, the fungi can also infect the skin of the fingers (tinea manuum), and burrow underneath and into the material of the fingernails (tinea unguium). If left untreated, the fungi continue to grow and spread.

Treatments

A variety of zoophilic and anthropophilic dermatophyte treatments have varying levels of success based on species type. Treatments may take up to six months. [8]

Related Research Articles

<span class="mw-page-title-main">Tinea cruris</span> Fungal infection

Tinea cruris, also known as jock itch, is a common type of contagious, superficial fungal infection of the groin and buttocks region, which occurs predominantly but not exclusively in men and in hot-humid climates.

<span class="mw-page-title-main">Athlete's foot</span> Skin infection caused by fungus

Athlete's foot, known medically as tinea pedis, is a common skin infection of the feet caused by a fungus. Signs and symptoms often include itching, scaling, cracking and redness. In rare cases the skin may blister. Athlete's foot fungus may infect any part of the foot, but most often grows between the toes. The next most common area is the bottom of the foot. The same fungus may also affect the nails or the hands. It is a member of the group of diseases known as tinea.

Dermatophyte is a common label for a group of fungus of Arthrodermataceae that commonly causes skin disease in animals and humans. Traditionally, these anamorphic mold genera are: Microsporum, Epidermophyton and Trichophyton. There are about 40 species in these three genera. Species capable of reproducing sexually belong in the teleomorphic genus Arthroderma, of the Ascomycota. As of 2019 a total of nine genera are identified and new phylogenetic taxonomy has been proposed.

<span class="mw-page-title-main">Tinea capitis</span> Cutaneous fungal infection of the scalp

Tinea capitis is a cutaneous fungal infection (dermatophytosis) of the scalp. The disease is primarily caused by dermatophytes in the genera Trichophyton and Microsporum that invade the hair shaft. The clinical presentation is typically single or multiple patches of hair loss, sometimes with a 'black dot' pattern, that may be accompanied by inflammation, scaling, pustules, and itching. Uncommon in adults, tinea capitis is predominantly seen in pre-pubertal children, more often boys than girls.

<span class="mw-page-title-main">Dermatophytosis</span> Fungal infection of the skin

Dermatophytosis, also known as ringworm, is a fungal infection of the skin. Typically it results in a red, itchy, scaly, circular rash. Hair loss may occur in the area affected. Symptoms begin four to fourteen days after exposure. Multiple areas can be affected at a given time.

<span class="mw-page-title-main">Onychomycosis</span> Medical condition

Onychomycosis, also known as tinea unguium, is a fungal infection of the nail. Symptoms may include white or yellow nail discoloration, thickening of the nail, and separation of the nail from the nail bed. Fingernails may be affected, but it is more common for toenails. Complications may include cellulitis of the lower leg. A number of different types of fungus can cause onychomycosis, including dermatophytes and Fusarium. Risk factors include athlete's foot, other nail diseases, exposure to someone with the condition, peripheral vascular disease, and poor immune function. The diagnosis is generally suspected based on the appearance and confirmed by laboratory testing.

<span class="mw-page-title-main">Kerion</span> Medical condition

Kerion or kerion celsi is an acute inflammatory process which is the result of the host's response to a fungal ringworm infection of the hair follicles of the scalp that can be accompanied by secondary bacterial infection(s). It usually appears as raised, spongy lesions, and typically occurs in children. This honeycomb is a painful inflammatory reaction with deep suppurative lesions on the scalp. Follicles may be seen discharging pus. There may be sinus formation and rarely mycetoma-like grains are produced. It is usually caused by dermatophytes such as Trichophyton verrucosum, T. mentagrophytes, and Microsporum canis. Treatment with oral griseofulvin common.

<span class="mw-page-title-main">Tinea manuum</span> Medical condition

Tinea manuum is a fungal infection of the hand, mostly a type of dermatophytosis, often part of two feet-one hand syndrome. There is diffuse scaling on the palms or back of usually one hand and the palmer creases appear more prominent. When both hands are affected, the rash looks different on each hand, with palmer creases appearing whitish if the infection has been present for a long time. It can be itchy and look slightly raised. Nails may also be affected.

<span class="mw-page-title-main">KOH test</span> Test to differentiate between skin fungi

The KOH Test for Candida albicans, also known as a potassium hydroxide preparation or KOH prep, is a quick, inexpensive fungal test to differentiate dermatophytes and Candida albicans symptoms from other skin disorders like psoriasis and eczema.

<i>Trichophyton rubrum</i> Species of fungus

Trichophyton rubrum is a dermatophytic fungus in the phylum Ascomycota. It is an exclusively clonal, anthropophilic saprotroph that colonizes the upper layers of dead skin, and is the most common cause of athlete's foot, fungal infection of nail, jock itch, and ringworm worldwide. Trichophyton rubrum was first described by Malmsten in 1845 and is currently considered to be a complex of species that comprises multiple, geographically patterned morphotypes, several of which have been formally described as distinct taxa, including T. raubitschekii, T. gourvilii, T. megninii and T. soudanense.

<i>Trichophyton interdigitale</i> Species of fungus

Trichophyton interdigitale is a clonal line within sexual species T. mentagrophytes. It causes onychomycosis and tinea pedis in humans, and has never been isolated from animals. Trichophyton interdigitale isolates cannot be reliably discriminated from T. mentagrophytes by cultural techniques or MALDI-TOF mass spectrometry, and therefore ITS region DNA sequencing is recommended.

<i>Trichophyton mentagrophytes</i> Species of fungus

Trichophyton mentagrophytes is a species in the fungal genus Trichophyton. It is one of three common fungi which cause ringworm in companion animals. It is also the second-most commonly isolated fungus causing tinea infections in humans, and the most common or one of the most common fungi that cause zoonotic skin disease. Trichophyton mentagrophytes is being frequently isolated from dogs, cats, rabbits, guinea pigs and other rodents, though at least some genetic variants possess the potential of human-to-human transmission, e.g. Type VII and Type VIII. Particular genetic variants of the fungus have distinct geographic ranges.

<i>Microsporum canis</i> Species of fungus

Microsporum canis is a pathogenic, asexual fungus in the phylum Ascomycota that infects the upper, dead layers of skin on domesticated cats, and occasionally dogs and humans. The species has a worldwide distribution.

Trichophyton concentricum is an anthropophilic dermatophyte believed to be an etiological agent of a type of skin mycosis in humans, evidenced by scaly cutaneous patches on the body known as tinea imbricata. This fungus has been found mainly in the Pacific Islands and South America.

Microsporum nanum is a pathogenic fungus in the family Arthrodermataceae. It is a type of dermatophyte that causes infection in dead keratinized tissues such as skin, hair, and nails. Microsporum nanum is found worldwide and is both zoophilic and geophilic. Animals such as pigs and sheep are the natural hosts for the fungus; however, infection of humans is also possible. Majority of the human cases reported are associated with pig farming. The fungus can invade the skin of the host; if it is scratched off by the infected animal, the fungus is still capable of reproducing in soil.

<i>Microsporum gallinae</i> Species of fungus

Microsporum gallinae is a fungus of the genus Microsporum that causes dermatophytosis, commonly known as ringworm. Chickens represent the host population of Microsporum gallinae but its opportunistic nature allows it to enter other populations of fowl, mice, squirrels, cats, dogs and monkeys. Human cases of M. gallinae are rare, and usually mild, non-life-threatening superficial infections.

<span class="mw-page-title-main">Favus</span> Medical condition

Favus or tinea favosa is the severe form of tinea capitis, a skin infectious disease caused by the dermatophyte fungus Trichophyton schoenleinii. Typically the species affects the scalp, but occasionally occurs as onychomycosis, tinea barbae, or tinea corporis.

<i>Trichophyton verrucosum</i> Species of fungus

Trichophyton verrucosum, commonly known as the cattle ringworm fungus, is a dermatophyte largely responsible for fungal skin disease in cattle, but is also a common cause of ringworm in donkeys, dogs, goat, sheep, and horses. It has a worldwide distribution, however human infection is more common in rural areas where contact with animals is more frequent, and can cause severe inflammation of the afflicted region. Trichophyton verrucosum was first described by Emile Bodin in 1902.

<i>Epidermophyton floccosum</i> Species of fungus

Epidermophyton floccosum is a filamentous fungus that causes skin and nail infections in humans. This anthropophilic dermatophyte can lead to diseases such as tinea pedis, tinea cruris, tinea corporis and onychomycosis. Diagnostic approaches of the fungal infection include physical examination, culture testing, and molecular detection. Topical antifungal treatment, such as the use of terbinafine, itraconazole, voriconazole, and ketoconazole, is often effective.

References

  1. de Hoog GS, Dukik K, Monod M, et al. (2017). "Toward a novel multilocus phylogenetic taxonomy for the dermatophytes". Mycopathologia . 182 (1–2): 5–31. doi: 10.1007/s11046-016-0073-9 . PMC   5283515 . PMID   27783317.
  2. "Trichophyton - Search Page". www.speciesfungorum.org. Species Fungorum. Retrieved 2023-05-15.
  3. Kawasaki, Masako; Anzawa, Kazushi; Wakasa, Asako; Takeda, Kiminobu; Mochizuki, Takashi; Ishizaki, Hiroshi; Hemashettar, Basavaraj (2010). "Matings among Three Teleomorphs of Trichophyton mentagrophytes". Nippon Ishinkin Gakkai Zasshi. 51 (3): 143–152. doi: 10.3314/jjmm.51.143 . PMID   20716853.
  4. Weitzman, I.; Allderdice, P. W.; Silva-Hutner, M.; Miller, O. J. (1968). "Meiosis in Arthroderma benhamiae (=Trichophyton mentagrophytes)". Sabouraudia. 6 (3): 232–237. doi:10.1080/00362176885190441. PMID   5679669.
  5. "Malabar itch - definition from Biology-Online.org". Archived from the original on 2016-03-30. Retrieved 2008-06-17.
  6. Boral, Hazal; Durdu, Murat; Ilkit, Macit (2018). "Majocchi's granuloma: current perspectives". Infection and Drug Resistance. 11: 751–760. doi: 10.2147/IDR.S145027 . PMC   5968791 . PMID   29861637.
  7. Crain, Caroline B.; Rana, Arathi; Winsett, Frank T.; Wilkerson, Michael G. (2019). "Two Rare Cases of Tinea Corporis Caused by Trichophyton verrucosum and Trichophyton interdigitale in a Teenage Girl". Cureus. 11 (8): e5325. doi: 10.7759/cureus.5325 . ISSN   2168-8184. PMC   6777930 . PMID   31598432.
  8. Łagowsk, Dominik; Gnat, Sebastian; Nowakiewicz, Aneta; Osińska, Marcelina (2020). "Comparison of in vitro activities of 11 antifungal agents against Trichophyton verrucosum isolates associated with a variety hosts and geographical origin". Mycoses. 63 (3): 294–301. doi:10.1111/myc.13042. PMID   31820493. S2CID   209165839.