Interstate 70 (I-70) is a major east–west Interstate Highway in the United States that runs from I-15 near Cove Fort, Utah, to I-695 and Maryland Route 570 (MD 570) in Woodlawn, just outside Baltimore, Maryland.
Interstate 65 (I-65) is a major north–south Interstate Highway in the central United States. As with most primary Interstates ending in 5, it is a major crosscountry, north–south route, connecting between the Great Lakes and the Gulf of Mexico. Its southern terminus is located at an interchange with I-10 in Mobile, Alabama, and its northern terminus is at an interchange with US 12 (US 12) and US 20 in Gary, Indiana, just southeast of Chicago. I-65 connects several major metropolitan areas in the Midwest and Southern US. It connects the four largest cities in Alabama: Mobile, Montgomery, Birmingham, and Huntsville. It also serves as one of the main north–south routes through Nashville, Tennessee; Louisville, Kentucky; and Indianapolis, Indiana, each a major metropolitan area in its respective state.
Interstate 69 (I-69) is an Interstate Highway in the United States currently consisting of eight unconnected segments. The longest segment runs from Evansville, Indiana, northeast to the Canadian border in Port Huron, Michigan, and includes the original continuous segment from Indianapolis, Indiana, to Port Huron of 355.8 miles (572.6 km). The remaining separated segments are variously completed and posted or not posted sections of an extension southwest to the Mexican border in Texas. Of this extension—nicknamed the NAFTA Superhighway because it would help trade with Canada and Mexico spurred by the North American Free Trade Agreement (NAFTA)—seven pieces in Laredo, Texas; Pharr, Texas; Brownsville, Texas; Corpus Christi, Texas; Houston, Texas; northwestern Mississippi; and Memphis, Tennessee, have been built or upgraded and signposted as I-69. Indiana completed the fifth segment that extends I-69 through that state in August 2024.
U.S. Route 31 or U.S. Highway 31 (US 31) is a major north–south U.S. highway connecting southern Alabama to northern Michigan. Its southern terminus is at an intersection with US 90/US 98 in Spanish Fort, Alabama. Its northern terminus is at an interchange with Interstate 75 (I-75) south of Mackinaw City, Michigan.
State Road 37 (SR 37) is a major route in the U.S. state of Indiana, running as a four-lane divided highway for 110 miles of its course.
U.S. Route 35 (US 35) is a United States Highway that runs southeast-northwest for approximately 412 miles (663 km) from the western suburbs of Charleston, West Virginia to northern Indiana. Although the highway is physically southeast-northwest, it is nominally north–south. The highway's southern terminus is in Teays Valley, West Virginia, near Scott Depot, at Interstate 64 (I-64). Its northern terminus is near Michigan City, Indiana, at US 20. The West Virginia portion of the highway is mostly expressway, becoming a freeway shortly before it crosses the Ohio River into Ohio. The Ohio portion has been upgraded to a four-lane highway/freeway between the West Virginia state line and Trotwood, west of Dayton.
U.S. Route 36 (US 36) is an east–west United States Numbered Highway that travels approximately 1,414 miles (2,276 km) from Rocky Mountain National Park, Colorado to Uhrichsville, Ohio. The highway's western terminus is at Deer Ridge Junction, an intersection in Rocky Mountain National Park, Colorado, where it meets US 34. Its eastern terminus is at US 250 in Uhrichsville, Ohio.
Interstate 465 (I-465), also known as the USS Indianapolis Memorial Highway, is the beltway circling Indianapolis, Indiana. It is roughly rectangular in shape and has a perimeter of approximately 53 miles (85 km). It lies almost completely within the boundaries of Marion County, except for two short sections on the north leg in Boone and Hamilton counties. It intersects with I-65, I-69, I-70, and I-74 and provides additional access to I-65 via I-865.
Interstate 865 (I-865) is an east–west auxiliary Interstate Highway northwest of Indianapolis, Indiana. It is a short connector between I-65 and I-465, running for five miles (8.0 km) and completely concurrent with U.S. Route 52 (US 52). The highway was originally numbered as a branch of I-465 but was renumbered in 2002 to prevent I-465 from intersecting with itself. This section was previously known as the Dog Leg, and the mile markers ran from 900 to 905.
State Road 67 in the U.S. state of Indiana cuts a diagonal route from southwest to northeast across the state from the north side of Vincennes to Indianapolis to the Ohio state line, where it becomes State Route 29 east of Bryant.
State Road 14 is an east–west highway route which traverses the northern portion of the U.S. State of Indiana. Its western terminus is at U.S. Route 41 in Enos, and since 1995 its eastern terminus is at Interstate 69 in Fort Wayne.
Interstate 65 (I-65) in the US state of Indiana traverses from the south-southeastern Falls City area bordering Louisville, Kentucky, through the centrally located capital city of Indianapolis, to the northwestern Calumet Region of the Hoosier State which is part of the Chicago metropolitan area. The Indiana portion of I-65 begins in Jeffersonville after crossing the Ohio River and travels mainly north, passing just west of Columbus prior to reaching the Indianapolis metro area. Upon reaching Indianapolis, the route alignment of I-65 begins to run more to the northwest and subsequently passes Lafayette on that city's east and north sides. Northwest of there, in west-central Jasper County, the route again curves more northward as it approaches the Calumet Region. Shortly after passing a major junction with I-80 and I-94, I-65 reaches its northern national terminus in Gary at US Highway 12/US Highway 20 after an interchange on I-90. I-65 covers 261.27 miles (420.47 km) in the state of Indiana. This is one of the principal Interstate Highways that cross the state, and, more specifically, intersect at the city of Indianapolis, that has given the state the nickname of "Crossroads of America".
Interstate 70 (I-70) in the US state of Indiana travels east–west across the central portion of the state, passing through the capital of Indianapolis. I-70 crosses from Illinois into Indiana near Terre Haute and departs into Ohio at Richmond. It covers 156.6 miles (252.0 km) in Indiana, paralleling U.S. Highway 40 (US 40), the old National Road.
Interstate 69 (I-69), also known as the Iraq Afghanistan Veterans Memorial Highway south of Indianapolis, in the US state of Indiana travels southwest to northeast, connecting all 3 of the state's largest cities, Evansville, Indianapolis, and Fort Wayne. The highway proceeds north to the state of Michigan, reaching its capital city, Lansing and beyond, and is planned to eventually proceed south to the state of Kentucky and beyond.
U.S. Route 27 (US 27) is a part of the United States Numbered Highway System that runs from Miami, Florida, to Fort Wayne in the U.S. state of Indiana. In Indiana, it is a state road that enters the state in College Corner, Ohio, and West College Corner. The 117.765 miles (189.524 km) of US 27 that lie within Indiana serve as a major conduit. Most of the highway is listed on the National Highway System. Various sections are a rural two-lane highway or an urbanized four-lane divided highway. The northernmost community along the highway is Fort Wayne in the northeast part of the state. The highway ends at an interchange with Interstate 69 (I-69) north of downtown Fort Wayne after serving the east central and northeast regions of Indiana.
U.S. Route 31 (US 31) is a part of the United States Numbered Highway System that runs from Spanish Fort, Alabama, to Mackinaw City, Michigan. It enters the U.S. state of Indiana via the George Rogers Clark Memorial Bridge between Louisville, Kentucky, and Clarksville, Indiana. The 257.6 miles (414.57 km) of US 31 that lie within Indiana serve as a major conduit. Some of the highway is listed on the National Highway System. Various sections are rural two-lane highway and urbanized four- or six-lane divided expressway. The northernmost community along the highway is South Bend near the Michigan state line.
U.S. Route 150 (US 150) in Indiana is a 176.315-mile-long (283.751 km) east–west highway that travels from the Illinois state line east of Paris, Illinois to Louisville, Kentucky at the Kentucky state line. A section of US 150 from New Goshen to Vincennes travels north–south instead of east–west. US 150 travels concurrently with its parent route, US 50, from Vincennes to Shoals. Between West Terre Haute and Terre Haute, US 150 travels along part of the historic National Road. Also, from Vincennes to New Albany, the route is designated as part of Indiana's Historic Pathways, as it roughly parallels what was then part of the Buffalo Trace.
U.S. Route 136 (US 136) is a part of the United States Numbered Highway that runs from Edison, Nebraska, to Speedway, Indiana. In Indiana, it is part of the Indiana State Road system that enters between Danville, Illinois, and Foster, Indiana. The 75.30 miles (121.2 km) of US 136 that lie within Indiana serve as a major conduit. Some sections of the highway are listed on the National Highway System. Various sections are rural two-lane highway and urbanized four-lane divided highways. The easternmost community along the highway is Speedway, near Indianapolis.
U.S. Route 231 is the longest numbered highway in Indiana, covering over 284 miles (457 km). It is a main north–south highway in the western part of the state. The southern terminus of US 231 in Indiana is at the Kentucky state line and the northern terminus is at US 41 just south of St. John. The highway is a mixture of expressway and two-lane roadway. The expressway portions exist mainly in southern Indiana and around the Lafayette-West Lafayette area, with the rest mainly being two lanes.
US 36 west of Dana 
