U.S. Route 52 (US 52) is a major United States highway in the central United States that extends from the northern to southeastern region of the United States. Contrary to most other even-numbered U.S. Highways, US 52 primarily follows a northwest–southeast route, and is signed north–south or east–west depending on the local orientation of the route. The highway's northwestern terminus is in Portal, North Dakota at the Canada–United States border, where it continues as Saskatchewan Highway 39. Its southeastern terminus is in Charleston, South Carolina, at Number 2 Meeting Street and White Point Garden along the Charleston Harbor.
State Road 37 (SR 37) is a major route in the U.S. state of Indiana, running as a four-lane divided highway for 110 miles of its course.
U.S. Route 35 (US 35) is a United States Highway that runs southeast-northwest for approximately 412 miles (663 km) from the western suburbs of Charleston, West Virginia to northern Indiana. Although the highway is physically southeast-northwest, it is nominally north–south. The highway's southern terminus is in Teays Valley, West Virginia, near Scott Depot, at Interstate 64 (I-64). Its northern terminus is near Michigan City, Indiana, at US 20. The West Virginia portion of the highway is mostly expressway, becoming a freeway shortly before it crosses the Ohio River into Ohio. The Ohio portion has been upgraded to a four-lane highway/freeway between the West Virginia state line and Trotwood, west of Dayton.
U.S. Route 36 (US 36) is an east–west United States Numbered Highway that travels approximately 1,414 miles (2,276 km) from Rocky Mountain National Park, Colorado to Uhrichsville, Ohio. The highway's western terminus is at Deer Ridge Junction, an intersection in Rocky Mountain National Park, Colorado, where it meets US 34. Its eastern terminus is at US 250 in Uhrichsville, Ohio.
U.S. Route 421 is a diagonal northwest–southeast United States Numbered Highway in the states of North Carolina, Tennessee, Virginia, Kentucky, and Indiana. The highway runs for 941 miles (1,514 km) from Fort Fisher, North Carolina, to US 20 in Michigan City, Indiana. Along its routing, US 421 serves several cities including Wilmington, North Carolina; Greensboro, North Carolina; Bristol, Tennessee and Virginia; Lexington, Kentucky; and Indianapolis, Indiana. US 421 is a spur route of US 21, which it meets west of Yadkinville, North Carolina.
Interstate 465 (I-465), also known as the USS Indianapolis Memorial Highway, is the beltway circling Indianapolis, Indiana. It is roughly rectangular in shape and has a perimeter of approximately 53 miles (85 km). It lies almost completely within the boundaries of Marion County, except for two short sections on the north leg in Boone and Hamilton counties. It intersects with I-65, I-69, I-70, and I-74 and provides additional access to I-65 via I-865.
State Road 1 (SR 1) is a north–south state highway in eastern Indiana, consisting of two segments. Its southern segment begins at U.S. Highway 50 and Interstate 275 in east-central Dearborn County, just east of Lawrenceburg, and ends at Interstate 469 south of Fort Wayne. Its northern segment begins at Interstate 69 on Fort Wayne's north side, and ends at U.S. Route 20 in east-central Steuben County, approximately 6 miles (9.7 km) east of Angola.
State Road 3 (SR 3) in the U.S. state of Indiana is a discontinuous state highway running through eastern Indiana from near the Ohio River to near the Michigan state line. The southernmost terminus is at SR 62 in Charlestown, and the northernmost terminus is at SR 120 near Brighton.
State Road 135 (SR 135) in the U.S. State of Indiana is a road that connects Indianapolis with the Ohio River; for the most part it is a two-lane road except for near Greenwood and Indianapolis.
State Road 332 (SR 332) is a part of the Indiana State Road that runs between Interstate 69 (I–69) and Muncie in US state of Indiana. The 7.64 miles (12.30 km) of SR 332 that lie within Indiana serve as a minor highway. No section of the highway is listed on the National Highway System. Various sections are rural four-lane divided highway and urban four-lane highway. The highway passes through farmland, residential and commercial properties.
Interstate 65 (I-65) in the US state of Indiana traverses from the south-southeastern Falls City area bordering Louisville, Kentucky, through the centrally located capital city of Indianapolis, to the northwestern Calumet Region of the Hoosier State which is part of the Chicago metropolitan area. The Indiana portion of I-65 begins in Jeffersonville after crossing the Ohio River and travels mainly north, passing just west of Columbus prior to reaching the Indianapolis metro area. Upon reaching Indianapolis, the route alignment of I-65 begins to run more to the northwest and subsequently passes Lafayette on that city's east and north sides. Northwest of there, in west-central Jasper County, the route again curves more northward as it approaches the Calumet Region. Shortly after passing a major junction with I-80 and I-94, I-65 reaches its northern national terminus in Gary at US Highway 12/US Highway 20 after an interchange on I-90. I-65 covers 261.27 miles (420.47 km) in the state of Indiana. This is one of the principal Interstate Highways that cross the state, and, more specifically, intersect at the city of Indianapolis, that has given the state the nickname of "Crossroads of America".
U.S. Route 41 (US 41) in the state of Indiana is a north–south US Highway that is parallel to the Illinois state line. It enters the state south of Evansville as a four-lane divided highway passing around Vincennes and traveling north to Terre Haute. In Terre Haute, it is known as 3rd Street. North of Terre Haute, it hooks east and becomes a two-lane surface road. Those wanting to stay on a four-lane divided highway can use State Road 63 to the west. It passes through Rockville, Veedersburg, and Attica before returning to a four-lane divided highway when SR 63 terminates in Warren County. It remains a four-lane divided highway until Lake County, where it becomes a main road known as Indianapolis Boulevard. It overlaps US 12 and US 20 in Hammond and exits Indiana into the South Side of Chicago.
Interstate 69 (I-69), also known as the Iraq Afghanistan Veterans Memorial Highway south of Indianapolis, in the US state of Indiana travels southwest to northeast, connecting all 3 of the state's largest cities, Evansville, Indianapolis, and Fort Wayne. The highway proceeds north to the state of Michigan, reaching its capital city, Lansing and beyond, and is planned to eventually proceed south to the state of Kentucky and beyond.
U.S. Route 33 (US 33) is part of the United States Numbered Highway System that runs from Richmond, Virginia, to Elkhart of the US state of Indiana. In Indiana, it is a state road that enters the state at the Ohio state line between Willshire, Ohio, and Pleasant Mills, Indiana. The 106.217 miles (170.940 km) of US 33 that lie within Indiana serve as a major conduit. All of the highway is listed on the National Highway System. Various sections are rural two-lane highway, urbanized four-lane divided expressway and the Lincoln Highway. The northernmost community along the highway is Elkhart. The highway ends at an interchange in southern Elkhart after serving the northeastern region of Indiana. US 33 passes through farm fields and urban areas.
U.S. Route 20 (US 20) in Indiana is a main east–west highway that is parallel to the Indiana Toll Road. The western terminus of US 20 is at the Illinois state line and the eastern terminus is at the Ohio state line. US 20 through Whiting, East Chicago, and Gary is concurrent with US 12 twice. The route varies between one-way, two-lane, and four-lane streets, in Northwest Indiana. From the east side of Gary to west of South Bend, US 20 is a four-lane undivided highway. The route then heads around the west and south sides of South Bend and Elkhart as a four-lane limited access divided highway. East of State Road 15 (SR 15), US 20 is two-lane rural highway.
U.S. Route 31 (US 31) is a part of the United States Numbered Highway System that runs from Spanish Fort, Alabama, to Mackinaw City, Michigan. It enters the U.S. state of Indiana via the George Rogers Clark Memorial Bridge between Louisville, Kentucky, and Clarksville, Indiana. The 257.6 miles (414.57 km) of US 31 that lie within Indiana serve as a major conduit. Some of the highway is listed on the National Highway System. Various sections are rural two-lane highway and urbanized four- or six-lane divided expressway. The northernmost community along the highway is South Bend near the Michigan state line.
U.S. Route 421 (US 421) enters Indiana from Kentucky, proceeding northwest to Indianapolis, joining Interstate 465, and then continuing northwest to Michigan City.
U.S. Route 36 is a part of the United States Numbered Highway System that runs from Rocky Mountain National Park, Colorado to Uhrichsville, Ohio. In the state of Indiana, it is part of the Indiana State Road system that runs across the central portion of the state from the Illinois state line near Dana to the Ohio state line near Spartanburg. In the Indianapolis area, US 36 overlaps the southern section of Interstate 465 (I-465), bypassing the downtown area where the route formerly went.
U.S. Route 24 (US 24) in Indiana runs east from the Illinois state line to Huntington. At Huntington, US 24 turns northeast and runs to Fort Wayne; it then runs concurrently with Interstate 69 (I-69) and I-469 to bypass the city before entering Ohio at the state line east of Fort Wayne. The segment of US 24 between Logansport and Toledo, Ohio, is part of the Hoosier Heartland Industrial Corridor project of the Intermodal Surface Transportation Efficiency Act.
US 41 / US 150 near Vincennes 
SR 29 near Celina, Ohio 
