1-alkenylglycerophosphocholine O-acyltransferase

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1-alkenylglycerophosphocholine O-acyltransferase
Identifiers
EC no. 2.3.1.104
CAS no. 102925-32-6
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MetaCyc metabolic pathway
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In enzymology, a 1-alkenylglycerophosphocholine O-acyltransferase (EC 2.3.1.104) is an enzyme that catalyzes the chemical reaction

acyl-CoA + 1-alkenylglycerophosphocholine CoA + 1-alkenyl-2-acylglycerophosphocholine

Thus, the two substrates of this enzyme are acyl-CoA and 1-alkenylglycerophosphocholine, whereas its two products are CoA and 1-alkenyl-2-acylglycerophosphocholine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-alkenylglycerophosphocholine O-acyltransferase. This enzyme participates in ether lipid metabolism.

Related Research Articles

<span class="mw-page-title-main">Plasmalogen</span> Subclass of Glycerophospholipids

Glycerophospholipids of biochemical relevance are divided into three subclasses based on the substitution present at the sn-1 position of the glycerol backbone: acyl, alkyl and alkenyl. Of these, the alkyl and alkenyl moiety in each case form an ether bond, which makes for two types of ether phospholipids, plasmanyl, and plasmenyl. Plasmalogens are plasmenyls with an ester linked lipid at the sn-2 position of the glycerol backbone, chemically designated 1-0(1Z-alkenyl)-2-acyl-glycerophospholipids. The lipid attached to the vinyl ether at sn-1 can be C16:0, C18:0, or C18:1, and the lipid attached to the acyl group at sn-2 can be C22:6 ω-3 or C20:4 ω-6, . Plasmalogens are classified according to their head group, mainly as PC plasmalogens (plasmenylcholines) and PE plasmalogens (plasmenylethalomines) Plasmalogens should not be confused with plasmanyls.

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<span class="mw-page-title-main">1-Lysophosphatidylcholine</span>

2-acyl-sn-glycero-3-phosphocholines are a class of phospholipids that are intermediates in the metabolism of lipids. Because they result from the hydrolysis of an acyl group from the sn-1 position of phosphatidylcholine, they are also called 1-lysophosphatidylcholine. The synthesis of phosphatidylcholines with specific fatty acids occurs through the synthesis of 1-lysoPC. The formation of various other lipids generates 1-lysoPC as a by-product.

References


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