1-alkyl-2-acetylglycerol O-acyltransferase

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1-alkyl-2-acetylglycerol O-acyltransferase
Identifiers
EC no. 2.3.1.125
CAS no. 114704-90-4
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In enzymology, a 1-alkyl-2-acetylglycerol O-acyltransferase (EC 2.3.1.125) is an enzyme that catalyzes the chemical reaction

acyl-CoA + 1-O-alkyl-2-acetyl-sn-glycerol CoA + 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol

Thus, the two substrates of this enzyme are acyl-CoA and 1-O-alkyl-2-acetyl-sn-glycerol, whereas its two products are CoA and 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase. This enzyme is also called 1-hexadecyl-2-acetylglycerol acyltransferase. This enzyme participates in ether lipid metabolism.

Related Research Articles

<span class="mw-page-title-main">Glycerophospholipid</span> Class of lipids

Glycerophospholipids or phosphoglycerides are glycerol-based phospholipids. They are the main component of biological membranes. Two major classes are known: those for bacteria and eukaryotes and a separate family for archaea.

<span class="mw-page-title-main">Plasmalogen</span> Subclass of Glycerophospholipids

Glycerophospholipids of biochemical relevance are divided into three subclasses based on the substitution present at the sn-1 position of the glycerol backbone: acyl, alkyl and alkenyl. Of these, the alkyl and alkenyl moiety in each case form an ether bond, which makes for two types of ether phospholipids, plasmanyl, and plasmenyl. Plasmalogens are plasmenyls with an ester linked lipid at the sn-2 position of the glycerol backbone, chemically designated 1-0(1Z-alkenyl)-2-acyl-glycerophospholipids. The lipid attached to the vinyl ether at sn-1 can be C16:0, C18:0, or C18:1, and the lipid attached to the acyl group at sn-2 can be C22:6 ω-3 or C20:4 ω-6, . Plasmalogens are classified according to their head group, mainly as PC plasmalogens (plasmenylcholines) and PE plasmalogens (plasmenylethalomines) Plasmalogens should not be confused with plasmanyls.

<span class="mw-page-title-main">Ether lipid</span>

In an organic chemistry general sense, an ether lipid implies an ether bridge between an alkyl group and an unspecified alkyl or aryl group, not necessarily glycerol. If glycerol is involved, the compound is called a glyceryl ether, which may take the form of an alkylglycerol, an alkyl acyl glycerol, or in combination with a phosphatide group, a phospholipid.

sn-Glycerol 3-phosphate is the organic ion with the formula HOCH2CH(OH)CH2OPO32-. It is one of three stereoisomers of the ester of dibasic phosphoric acid (HOPO32-) and glycerol. It is a component of glycerophospholipids. From a historical reason, it is also known as L-glycerol 3-phosphate, D-glycerol 1-phosphate, L-α-glycerophosphoric acid.

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<span class="mw-page-title-main">1-Lysophosphatidylcholine</span>

2-acyl-sn-glycero-3-phosphocholines are a class of phospholipids that are intermediates in the metabolism of lipids. Because they result from the hydrolysis of an acyl group from the sn-1 position of phosphatidylcholine, they are also called 1-lysophosphatidylcholine. The synthesis of phosphatidylcholines with specific fatty acids occurs through the synthesis of 1-lysoPC. The formation of various other lipids generates 1-lysoPC as a by-product.

Glycerol-3-phosphate 2-O-acyltransferase is an enzyme with systematic name acyl-CoA:sn-glycerol 3-phosphate 2-O-acyltransferase. This enzyme catalyses the following chemical reaction

References